Patents by Inventor Karl-Heinz Giselbrecht

Karl-Heinz Giselbrecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10683245
    Abstract: A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula (1) wherein R1-R7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethylketone with a base and a first solvent to obtain a solution wherein the molar ratio of base to 1-naphthyl-2-aminoethylketone acid salt is at least 0.7, b) addition of hydrazine to obtain a 3-(1-naphthyl)-1H-pyrazoline, c) optionally adding a second solvent and/or at least partially removing the first solvent, and d) heating the reaction mixture to a temperature above 190° C. to obtain the compound of Formula (1).
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: June 16, 2020
    Assignee: Patheon Austria GMBH & Co. KG
    Inventor: Karl-Heinz Giselbrecht
  • Publication number: 20180186706
    Abstract: A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula (1) wherein R1-R7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethylketone with a base and a first solvent to obtain a solution wherein the molar ratio of base to 1-naphthyl-2-aminoethylketone acid salt is at least 0.7, b) addition of hydrazine to obtain a 3-(1-naphthyl)-1H-pyrazoline, c) optionally adding a second solvent and/or at least partially removing the first solvent, and d) heating the reaction mixture to a temperature above 190° C. to obtain the compound of Formula (1).
    Type: Application
    Filed: June 29, 2016
    Publication date: July 5, 2018
    Inventor: Karl-Heinz Giselbrecht
  • Patent number: 8691798
    Abstract: Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: April 8, 2014
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ulfried Feifer, Karl-Heinz Giselbrecht, Michael Wolberg
  • Publication number: 20130274499
    Abstract: Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.
    Type: Application
    Filed: June 7, 2013
    Publication date: October 17, 2013
    Inventors: Ulfried Felfer, Karl-Heinz Giselbrecht, Michael Wolberg
  • Patent number: 8481724
    Abstract: Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.
    Type: Grant
    Filed: September 24, 2012
    Date of Patent: July 9, 2013
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ulfried Felfer, Karl-Heinz Giselbrecht, Michael Wolberg
  • Patent number: 8299242
    Abstract: Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: October 30, 2012
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Ulfried Felfer, Karl-Heinz Giselbrecht, Michael Wolberg
  • Publication number: 20110003986
    Abstract: Disclosed herein are methods for synthesizing 2,4-pyrimidinediamines as well as intermediates used therein.
    Type: Application
    Filed: July 1, 2010
    Publication date: January 6, 2011
    Applicant: RIGEL PHARMACEUTICALS, INC.
    Inventors: Ulfried Felfer, Karl-Heinz Giselbrecht, Michael Wolberg
  • Patent number: 6258572
    Abstract: An improved process for preparing L-aspartic acid by enzyme-catalyzed reaction of fumaric acid with ammonia, in which process L-aspartic acid is precipitated out by nitric acid and the resultant mother liquor is subjected to a nanofiltration.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: July 10, 2001
    Assignee: DSM Fine Chemicals Austria Nfg GmbH & CoKG
    Inventors: Karl-Heinz Giselbrecht, Josef Schaller
  • Patent number: 5952206
    Abstract: An improved process for preparing L-aspartic acid by enzyme-catalyzed reaction of fumaric acid with ammonia, in which, after reaction has been completed, excess ammonia is removed from the reaction mixture, L-aspartic acid is precipitated by adding acetic acid or formic acid, whereupon formic acid and acetic acid are rereleased from the mother liquor by adding fumaric acid, and the ammonia released and the liberated formic or acetic acid and the ammonium fumarate formed in the liberation are reused for subsequent cycles.
    Type: Grant
    Filed: December 29, 1998
    Date of Patent: September 14, 1999
    Assignee: DSM Fine Chemicals Austria GmbH
    Inventors: Karl-Heinz Giselbrecht, Josef Schaller
  • Patent number: 5939580
    Abstract: Process for preparing glyoxylic esters or their hydrates in which a water-soluble salt of a maleic or fumaric monoester or a mixture thereof is reacted with ozone in aqueous solution at temperatures of from 0 to 50.degree. C., and the corresponding glyoxylic ester or its hydrate is isolated from the resulting reaction mixture.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: August 17, 1999
    Assignee: DSM Fine Chemicals Austria GmbH
    Inventors: Engelbert Kloimstein, Wolfram Hendel, Klaus Reiter, Christian Burger, Antonia Praus, Karl Heinz Giselbrecht, Eduard Perndorfer
  • Patent number: 5874637
    Abstract: Process for the purification of o-phthalaldehyde in which an alcoholic solution containing the crude, unpurified o-phthalaldehyde is adjusted to a pH between 0 and 3 at a temperature between 0.degree. and 60.degree. C., then an alkaline solution is added, and the corresponding dialkoxyphthalan is extracted from the organic phase and purified by distillation and, when required, converted into the purified o-phthalaldehyde by hydrolysis.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: February 23, 1999
    Assignee: DSM Chemie Linz GmbH
    Inventors: Karl Heinz Giselbrecht, Klaus Reiter, Eduard Perndorfer, Rudolf Hermanseder
  • Patent number: 5872153
    Abstract: A process for preparing an aqueous o-phthalaldehyde-glutaraldehyde solution which comprises converting an acetal of the o-phthalaldehyde in a 10 to 60% strength aqueous glutaraldehyde solution into o-phthalaldehyde at room temperature up to 100.degree. C. by eliminating the corresponding alcohol, and removing the eliminated alcohol to give the aqueous o-phthalaldehyde-glutaraldehyde solution.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: February 16, 1999
    Assignee: DSM Chemie Linz GmbH
    Inventors: Karl Heinz Giselbrecht, Eduard Perndorfer