Patents by Inventor Karlheinz Pfoertner

Karlheinz Pfoertner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5030739
    Abstract: The invention is directed to a process for the catalytic oxidation of an isoprenoid containing at least one allylic hydrogen atom, which process comprises reacting the isoprenoid with oxygen or an oxygen-containing gas in an inert solvent in the presence of a N-hydroxydicarboxylic acid imide of the formula ##STR1## wherein A-B stands for CH.sub.2 -CH.sub.2, CH.dbd.CH, an aromatic hydrocarbon residue or a group derived from one of these groups in which one or more hydrogen atoms is/are replaced by alkyl or halogen,to produce a primary of secondary hydroperoxide.The process of the invention is suitable for the manufacture of steroids, vitamins, odorant substances, carotinoids and the like.
    Type: Grant
    Filed: August 31, 1990
    Date of Patent: July 9, 1991
    Assignee: Hoffman-La Roche Inc.
    Inventors: Joseph Foricher, Claude Furbringer, Karlheinz Pfoertner
  • Patent number: 4582641
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 -R.sup.4 is hydrogen or chlorine, R.sup.5 is --COOMe or --SO.sub.3 Me, Me is an alkali metal cation and X is oxygen, sulfur or selenium,photosensitizers for the conversion of tachysterol into previtamin D are described. The tachysterol content in mixtures of previtamin D and tachysterol can be greatly reduced by UV-irradiation in the presence of such photosensitizers.
    Type: Grant
    Filed: June 26, 1985
    Date of Patent: April 15, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans-Jurgen Hansen, Karlheinz Pfoertner
  • Patent number: 4551214
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 -R.sup.4 is hydrogen or chlorine, R.sup.5 is --COOMe or --SO.sub.3 Me, Me is an alkali metal cation and X is oxygen, sulfur or selenium, photosensitizers for the conversion of tachysterol into previtamin D are described. The tachysterol content in mixtures of previtamin D and tachysterol can be greatly reduced by visible light irradiation in the presence of such photosensitizers.
    Type: Grant
    Filed: June 14, 1984
    Date of Patent: November 5, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans-Jurgen Hansen, Karlheinz Pfoertner
  • Patent number: 4360530
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are hydrogen, halogen or lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, independently, are hydrogen or lower alkyl; R.sup.8 is hydrogen, lower alkyl or formyl; R.sup.9 and R.sup.10, independently, are methyl or trifluoromethyl; and n is 0 (zero) or, when both R.sup.7 and R.sup.8 are lower alkyl, n is 0 (zero) or 1, prepared, inter alia, from p-aminobenzaldehydes which may be N-alkyl substituted, are described. The compounds of formula I are orally active antidiabetic agents.
    Type: Grant
    Filed: November 12, 1981
    Date of Patent: November 23, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karl Bernauer, Karlheinz Pfoertner
  • Patent number: 4317914
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2, independently, are hydrogen, halogen or lower alkyl; R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7, independently, are hydrogen or C.sub.1-3 alkyl; R.sup.8 is hydrogen, lower alkyl or formyl; R.sup.9 and R.sup.10, independently, are methyl or trifluoromethyl; and n is 0 (zero) or, when both R.sup.7 and R.sup.8 are lower alkyl, n is 0 (zero) or 1,prepared, inter alia, from p-aminobenzaldehydes which may be N-alkyl substituted, are described. The compounds of formula I are orally active antidiabetic agents.
    Type: Grant
    Filed: December 12, 1980
    Date of Patent: March 2, 1982
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karl Bernauer, Karlheinz Pfoertner
  • Patent number: 4230623
    Abstract: Pyrrolidine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as hereinafter described, prepared inter alia from the corresponding pyrrolines, are described. The compounds are useful as analgesic agents.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: October 28, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karl Bernauer, Karlheinz Pfoertner, Fernand Schneider, Hans Schmid, deceased, by Mary Margrith Baumann-Schmid, heir, by Maria Albertine Schmid-Suter, heir, by Jeannette Martha Wawrla-Schmid, heir, by Ernst Georges Schmid-Gautschi, heir
  • Patent number: 3991197
    Abstract: Compounds represented by the formula ##SPC1##Wherein R.sup.1 is a pyridyl, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is hydrogen, lower alkyl or benzyl and R.sup.4 is phenyl or phenyl substituted at one or more carbon atoms with one or more of halogen, lower alkyl, lower alkoxy, nitro or aminoand pharmaceutically acceptable acid addition salts thereof, having analgesic activity are disclosed.
    Type: Grant
    Filed: February 12, 1976
    Date of Patent: November 9, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karl Bernauer, Karlheinz Pfoertner, Fernand Schneider, Hans Schmid