Patents by Inventor Karlheinz R. Skowronek

Karlheinz R. Skowronek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE
    Patent number: 7826982
    Abstract: The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: November 2, 2010
    Assignees: Children's Hospital Medical Center, The Research Foundation of State University of New York
    Inventors: Yi Zheng, Nicolas Nassar, Karlheinz R. Skowronek