Patents by Inventor Karlo Perica

Karlo Perica has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cells Expressing FAS Ligand Polypeptides and FAS Knockout and Uses Thereof
    Publication number: 20240350547
    Abstract: The presently disclosed subject matter provides cells, compositions and methods for enhancing immune responses toward tumor. It relates to cells comprising: an antigen-recognizing receptor (e.g., a chimeric antigen receptor, a TCR, or a TCR like fusion molecule), a Fas ligand polypeptide (FasL), and a gene disruption of a Fas locus. The gene disruption of the Fas locus can improve the activity and/or efficiency of the cells. The presently disclosed cells, compositions, and methods can be used in allogeneic settings.
    Type: Application
    Filed: June 21, 2024
    Publication date: October 24, 2024
    Applicants: Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute for Cancer Research, Memorial Hospital for Cancer and Allied Diseases
    Inventors: Michel Sadelain, Karlo Perica
  • Nanoscale artificial antigen presenting cells
    Patent number: 11939595
    Abstract: This disclosure provides nano-scale Artificial Antigen Presenting Cells (aAPC), which deliver stimulatory signals to lymphocytes, including T-helper lymphocytes, for use as a powerful tool for immunotherapy.
    Type: Grant
    Filed: August 23, 2019
    Date of Patent: March 26, 2024
    Assignee: The Johns Hopkins University
    Inventors: Jonathan Schneck, Mathias Oelke, Karlo Perica
  • REAGENTS AND METHODS FOR IDENTIFYING, ENRICHING, AND/OR EXPANDING ANTIGEN-SPECIFIC T CELLS
    Publication number: 20210252121
    Abstract: Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.
    Type: Application
    Filed: March 15, 2021
    Publication date: August 19, 2021
    Inventors: Jonathan Schneck, Karlo Perica, Joan Glick Bieler, Mathias Oelke
  • Reagents and methods for identifying, enriching, and/or expanding antigen-specific T cells
    Patent number: 10987412
    Abstract: Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: April 27, 2021
    Assignee: The John Hopkins University
    Inventors: Jonathan Schneck, Karlo Perica, Joan Glick Bieler, Mathias Oelke
  • ARTIFICIAL ANTIGEN PRESENTING CELLS HAVING A DEFINED AND DYNAMIC SHAPE
    Publication number: 20210046008
    Abstract: Compositions and methods comprising asymmetrical artificial antigen presenting cells (aAPCs) are disclosed. The non-spherical aAPCs more closely mimic endogenous cell-cell interactions and can be used for antigen-specific immunotherapy.
    Type: Application
    Filed: August 31, 2020
    Publication date: February 18, 2021
    Inventors: Jordan J. Green, Joel C. Sunshine, Karlo Perica, Jonathan Schneck
  • Artificial antigen presenting cells having a defined and dynamic shape
    Patent number: 10758487
    Abstract: Compositions and methods comprising asymmetrical artificial antigen presenting cells (aAPCs) are disclosed. The non-spherical aAPCs more closely mimic endogenous cell-cell interactions and can be used for antigen-specific immunotherapy.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: September 1, 2020
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jordan J. Green, Joel C. Sunshine, Karlo Perica, Jonathan Schneck
  • NANOSCALE ARTIFICIAL ANTIGEN PRESENTING CELLS
    Publication number: 20200095546
    Abstract: This disclosure provides nano-scale Artificial Antigen Presenting Cells (aAPC), which deliver stimulatory signals to lymphocytes, including cytotoxic lymphocytes, for use as a powerful tool for immunotherapy.
    Type: Application
    Filed: August 23, 2019
    Publication date: March 26, 2020
    Inventors: Jonathan Schneck, Mathias Oelke, Karlo Perica
  • Nanoscale artificial antigen presenting cells
    Patent number: 10435668
    Abstract: This disclosure provides nano-scale Artificial Antigen Presenting Cells (aAPC), which deliver stimulatory signals to lymphocytes, including cytotoxic lymphocytes, for use as a powerful tool for immunotherapy.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: October 8, 2019
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jonathan Schneck, Mathias Oelke, Karlo Perica
  • Reagents and methods for identifying, enriching, and/or expanding antigen-specific T cells
    Patent number: 10098939
    Abstract: Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: October 16, 2018
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jonathan Schneck, Karlo Perica, Joan Glick Bieler, Mathias Oelke
  • REAGENTS AND METHODS FOR IDENTIFYING, ENRICHING, AND/OR EXPANDING ANTIGEN-SPECIFIC T CELLS
    Publication number: 20180043003
    Abstract: Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.
    Type: Application
    Filed: October 23, 2017
    Publication date: February 15, 2018
    Inventors: Jonathan Schneck, Karlo Perica, Joan Glick Bieler, Mathias Oelke
  • REAGENTS AND METHODS FOR IDENTIFYING, ENRICHING, AND/OR EXPANDING ANTIGEN-SPECIFIC T CELLS
    Publication number: 20170246277
    Abstract: Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.
    Type: Application
    Filed: September 17, 2015
    Publication date: August 31, 2017
    Inventors: Jonathan Schneck, Karlo Perica, Joan Glick Bieler, Mathias Oelke
  • Nanoscale Artificial Antigen Presenting Cells
    Publication number: 20160051698
    Abstract: This disclosure provides nano-scale Artificial Antigen Presenting Cells (aAPC), which deliver stimulatory signals to lymphocytes, including cytotoxic lymphocytes, for use as a powerful tool for immunotherapy.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 25, 2016
    Inventors: Jonathan Schneck, Mathias Oelke, Karlo Perica
  • ARTIFICIAL ANTIGEN PRESENTING CELLS HAVING A DEFINED AND DYNAMIC SHAPE
    Publication number: 20140370099
    Abstract: Compositions and methods comprising asymmetrical artificial antigen presenting cells (aAPCs) are disclosed. The non-spherical aAPCs more closely mimic endogenous cell-cell interactions and can be used for antigen-specific immunotherapy.
    Type: Application
    Filed: December 10, 2012
    Publication date: December 18, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jordan J. Green, Joel C. Sunshine, Karlo Perica, Jonathan Schneck