Patents by Inventor Karolien De Bosscher

Karolien De Bosscher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synephrine derivatives useful as anti-inflammatory agents
    Patent number: 8039501
    Abstract: This invention provides compounds having the structural formula: wherein: R1 is an acyl or sulfonyl group, R2 is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic monocarboxylic acids, imidazolylcarbonyl and triazolylcarbonyl, and R3 is hydrogen or an amino-protecting group, a stereoisomer thereof, a solvate thereof, or a salt thereof, being useful as anti-inflammatory agents and anti-cancer agents.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: October 18, 2011
    Assignee: Universiteit Gent
    Inventors: Wim Vanden Berghe, Karolien De Bosscher, Serge Van Calenbergh, Guy Haegeman, Carl Jeffrey Lacey
  • COMPOSITION AND METHODS RELATING TO GLUCOCORTICOID RECEPTOR-ALPHA AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
    Publication number: 20100240627
    Abstract: Methods of treating a glucocorticoid-responsive condition in a subject are provided according to embodiments of the present invention which include administering, in combination, a glucocorticoid receptor agonist and a PPAR agonist in therapeutically effective amounts. It is an aspect of the present invention that the amount of the glucocorticoid receptor agonist used in a method of treating a glucocorticoid-responsive condition is less than an amount of the glucocorticoid receptor agonist necessary to achieve a therapeutic effect if administered in the absence of the PPAR agonist.
    Type: Application
    Filed: April 26, 2010
    Publication date: September 23, 2010
    Inventors: Karolien De Bosscher, Guy Haegeman, Nadia Bougarne, Bart Staels, Rejane Paumelle-Lestrelin
  • COMPOSITION AND METHODS RELATING TO GLUCOCORTICOID RECEPTOR-ALPHA AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS
    Publication number: 20090111782
    Abstract: Methods of treating a glucocorticoid-responsive condition in a subject are provided according to embodiments of the present invention which include administering, in combination, a glucocorticoid receptor agonist and a PPAR agonist in therapeutically effective amounts. It is an aspect of the present invention that the amount of the glucocorticoid receptor agonist used in a method of treating a glucocorticoid-responsive condition is less than an amount of the glucocorticoid receptor agonist necessary to achieve a therapeutic effect if administered in the absence of the PPAR agonist.
    Type: Application
    Filed: October 16, 2008
    Publication date: April 30, 2009
    Applicant: Ghent University
    Inventors: Karolien De Bosscher, Guy Haegeman, Nadia Bougarne
  • Synephrine derivatives useful as anti-inflammatory agents
    Publication number: 20090029999
    Abstract: This invention provides compounds having the structural formula: wherein: R1 is an acyl or sulfonyl group, R2 is an acyl group selected from the group consisting of acyl groups derived from cycloaliphatic, aromatic or heterocyclic monocarboxylic acids, imidazolylcarbonyl and triazolylcarbonyl, and R3 is hydrogen or an amino-protecting group, a stereoisomer thereof, a solvate thereof, or a salt thereof, being useful as anti-inflammatory agents and anti-cancer agents.
    Type: Application
    Filed: June 23, 2008
    Publication date: January 29, 2009
    Applicant: UNIVERSITEIT GENT
    Inventors: Wim VANDEN BERGHE, Karolien DE Bosscher, Serge Van Calenbergh, Guy Haegeman, Carl Jeffrey Lacey, Valerie Gossye, Ruben Hoya Arias, Sarah Gerlo
  • Use of carboxy compounds such as 2(4-acetoxyphenyl)2-chloro-N-methyl-ethylammonium chloride as anti-inflammatory agents
    Patent number: 7053120
    Abstract: The present invention relates to the use of specific carboxy compounds, more specifically to the use of 2(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride, in the treatment of inflammatory diseases. Part of the invention is also a composition, preferably a pharmaceutical composition, comprising as active ingredient at least 2 (4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride together with (pharmaceutically) acceptable excipients.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: May 30, 2006
    Assignee: Gent Universiteit
    Inventors: Karolien De Bosscher, Wim Vanden Berghe, Guy Haegeman
  • Use of carboxy compounds such as 2(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride as anti-inflammatory agents
    Publication number: 20030055030
    Abstract: The present invention relates to the use of specific carboxy compounds, more specifically to the use of 2(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride, in the treatment of inflammatory diseases. Part of the invention is also a composition, preferably a pharmaceutical composition, comprising as active ingredient at least 2 (4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride together with (pharmaceutically) acceptable excipients.
    Type: Application
    Filed: June 21, 2002
    Publication date: March 20, 2003
    Inventors: Karolien De Bosscher, Wim Vanden Berghe, Guy Haegeman