Patents by Inventor Karolien DE WAEL
Karolien DE WAEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11867704Abstract: A method for determining a narcotic in a mixture comprising at least one interferant. The method comprises: (a) determining a voltage at which, in absence of the interferant, a voltammetric signal of the narcotic can be detected; (b) contacting an electrode with the mixture comprising the at least one interferant and potentially comprising the narcotic; (c) applying a pretreatment potential to the electrode for a duration of at least 5 seconds, the pretreatment potential measuring between ?0.4 V and ?2 V versus Ag/AgCl; (d) measuring a voltammetric response of the mixture, the measurement comprising at least the determined voltage; and (e) determining whether the narcotic is present in the mixture by analyzing whether the voltammetric signal of the narcotic, resolved from a voltammetric signal of the interferant, can be detected in the measured voltammetric response.Type: GrantFiled: October 15, 2018Date of Patent: January 9, 2024Assignee: UNIVERSITEIT ANTWERPENInventors: Karolien De Wael, Mats De Jong, Anca Stefana Florea, Nick Sleegers
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Publication number: 20230236145Abstract: A computer-implemented method for interpreting an electrochemical response, comprises the steps of: (a) providing an electrochemical response that is baseline-corrected; (b) identifying in the electrochemical response one or more peaks that exceed a predetermined height threshold and a predetermined prominence threshold, each identified peak having a peak position; (c) providing a predetermined peak position range for each of a plurality of analytes; and (d) attributing one or more of the analytes to the peaks identified in step b, by, for each peak, associating the peak with an analyte when the peak position falls within the predetermined peak position range for the analyte.Type: ApplicationFiled: June 18, 2021Publication date: July 27, 2023Inventors: Karolien DE WAEL, Pierre VAN ESPEN, Robin VAN ECHELPOEL, Mats DE JONG
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Patent number: 11614423Abstract: The present invention relates to a method and system for obtaining an interaction property between a molecule or biomolecule or particle or bioparticle or nano- or microparticle on the one hand and a target particle on the other hand. The method comprises obtaining potentiometric titration results for a potentiometric measurement during titration of a solution with a titrant, said solution being a solution of one of a ligand of the target particle or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. Said titrant comprises the other of said target particle ligand or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. The method also comprises deriving based on said potentiometric titration results an interaction property between said molecule or biomolecule or particle or bioparticle or nano- or microparticle and said target particle.Type: GrantFiled: June 14, 2015Date of Patent: March 28, 2023Assignee: UNIVERSITEIT ANTWERPENInventors: Karolien De Wael, Luc Nagels, Guido Van Camp
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Publication number: 20220326172Abstract: A source of formaldehyde for methylating a primary or secondary amine is part of an electrochemical measurement. The source of formaldehyde may be an adduct of formaldehyde.Type: ApplicationFiled: August 31, 2020Publication date: October 13, 2022Inventors: Karolien DE WAEL, Saranya THIRUVOTTRIYUR SHANMUGAM
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Patent number: 10942142Abstract: Methods and apparatus for detecting an analyte using fluorinated phthalocyanines is disclosed herein. A method for detecting an analyte includes illuminating an analyte solution which contacts an electrode comprising a conductive material having a photosensitizer coupled thereto to generate a reactive oxygen species, wherein the photosensitizer is a fluorinated pthalocyanine having a metal or a non-metal center, oxidizing an analyte present in the analyte solution with the reactive oxygen species to form an oxidized analyte, and detecting a current resulting from the reduction of the oxidized analyte at the electrode.Type: GrantFiled: July 13, 2018Date of Patent: March 9, 2021Assignees: Seton Hall UniversityInventors: Karolien De Wael, Sergiu M. Gorun, Stanislav Trashin, Erik N. Carrión
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Publication number: 20200309799Abstract: A method for determining a narcotic in a mixture comprising at least one interferant. The method comprises: (a) determining a voltage at which, in absence of the interferant, a voltammetric signal of the narcotic can be detected; (b) contacting an electrode with the mixture comprising the at least one interferant and potentially comprising the narcotic; (c) applying a pretreatment potential to the electrode for a duration of at least 5 seconds, the pretreatment potential measuring between ?0.4 V and ?2 V versus Ag/AgCl; (d) measuring a voltammetric response of the mixture, the measurement comprising at least the determined voltage; and (e) determining whether the narcotic is present in the mixture by analyzing whether the voltammetric signal of the narcotic, resolved from a voltammetric signal of the interferant, can be detected in the measured voltammetric response.Type: ApplicationFiled: October 15, 2018Publication date: October 1, 2020Inventors: Karolien DE WAEL, Mats DE JONG, Anca Stefana FLOREA, Nick SLEEGERS
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Patent number: 10330677Abstract: This invention provides:—an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix;—a method of manufacturing said aptamer-based electrochemical sensor;—the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and—a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.Type: GrantFiled: September 13, 2017Date of Patent: June 25, 2019Assignee: Universiteit AntwerpenInventors: Ronny J. P. Blust, Freddy Dardenne, Karolien De Wael, Lucien Nagels, Guido F. E. Van Camp
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Publication number: 20190017955Abstract: Methods and apparatus for detecting an analyte using fluorinated phthalocyanines is disclosed herein. A method for detecting an analyte includes illuminating an analyte solution which contacts an electrode comprising a conductive material having a photosensitizer coupled thereto to generate a reactive oxygen species, wherein the photosensitizer is a fluorinated pthalocyanine having a metal or a non-metal center, oxidizing an analyte present in the analyte solution with the reactive oxygen species to form an oxidized analyte, and detecting a current resulting from the reduction of the oxidized analyte at the electrode.Type: ApplicationFiled: July 13, 2018Publication date: January 17, 2019Applicants: Seton Hall University, AXES Research Group, Department of Chemistry, University of Antwerp,Inventors: Karolien De Wael, Sergiu M. Gorun, Stanislav Trashin, Erik N. Carrión
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Publication number: 20180067108Abstract: This invention provides:—an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix;—a method of manufacturing said aptamer-based electrochemical sensor;—the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and—a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.Type: ApplicationFiled: September 13, 2017Publication date: March 8, 2018Inventors: Ronny J.P. BLUST, Freddy DARDENNE, Karolien DE WAEL, Lucien NAGELS, Guido F.E. VAN CAMP
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Patent number: 9791438Abstract: This invention provides: —an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix; —a method of manufacturing said aptamer-based electrochemical sensor; —the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and —a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.Type: GrantFiled: July 3, 2014Date of Patent: October 17, 2017Assignee: Universiteit AntwerpenInventors: Ronny J. P. Blust, Freddy Dardenne, Karolien De Wael, Lucien Nagels, Guido F. E. Van Camp
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Publication number: 20170122900Abstract: The present invention relates to a method and system for obtaining an interaction property between a molecule or biomolecule or particle or bioparticle or nano- or microparticle on the one hand and a target particle on the other hand. The method comprises obtaining potentiometric titration results for a potentiometric measurement during titration of a solution with a titrant, said solution being a solution of one of a ligand of the target particle or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. Said titrant comprises the other of said target particle ligand or said molecule or biomolecule or particle or bioparticle or nano- or microparticle. The method also comprises deriving based on said potentiometric titration results an interaction property between said molecule or biomolecule or particle or bioparticle or nano- or microparticle and said target particle.Type: ApplicationFiled: June 14, 2015Publication date: May 4, 2017Inventors: Karolien DE WAEL, Luc NAGELS, Guido VAN CAMP
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Patent number: 9594047Abstract: A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.Type: GrantFiled: April 16, 2014Date of Patent: March 14, 2017Assignee: UNIVERSITEIT ANTWERPENInventors: Karolien De Wael, Lucien Nagels, Guido Van Camp
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Publication number: 20160377606Abstract: This invention provides: —an aptamer-based electrochemical sensor, wherein said aptamer is covalently bonded to or chemisorbed on an electrode, said aptamer forming a complex with a target molecule and is encapsulated by a gelatin B matrix; —a method of manufacturing said aptamer-based electrochemical sensor; —the use of the aptamer-based electrochemical sensor for the electrochemical determination of a concentration of a target molecule; and —a composite electrode combining a polymeric material and electrically conducting particles for selective analyte detection, wherein said electrode is coated with gelatin type B.Type: ApplicationFiled: July 3, 2014Publication date: December 29, 2016Inventors: Ronny J.P. BLUST, Freddy DARDENNE, Karolien DE WAEL, Lucien NAGELS, Guido F.E. VAN CAMP
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Publication number: 20140318985Abstract: A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.Type: ApplicationFiled: April 16, 2014Publication date: October 30, 2014Applicant: Universiteit AntwerpenInventors: Karolien DE WAEL, Lucien Nagels, Guido Van Camp