Patents by Inventor Karoline Bechtold-Peters

Karoline Bechtold-Peters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170211959
    Abstract: A peristaltic dosing device for providing dosages of a fluid at a volume of less than one milliliter comprises: a flexible tube, a counter pressure element, a plurality of actors and a drive. The flexible tube is essentially straightly arranged along the counter pressure element thereby forming a longitudinal axis. The actors arranged parallel to each other along the longitudinal axis. They are moveable by the drive in relation to the flexible tube. The flexible tube is compressible between the actors and the counter pressure element by moving the actors. Each of the actors is independently and linearly moveable by the drive along an actuation axis essentially perpendicular to the longitudinal axis of the flexible tube from a home position in which the flexible tube is least compressed to an end position in which the flexible tube is compressed and sealed between the respective actor and the counter pressure element.
    Type: Application
    Filed: July 23, 2015
    Publication date: July 27, 2017
    Inventors: Michael ADLER, Karoline BECHTOLD-PETERS, Adeline BOILLON, Anke DORN, Joerg LUEMKEMANN, Denis LUTHRINGER, Hanns-Christian MAHLER, Alexander MEYER
  • Patent number: 8226982
    Abstract: The invention therefore relates to protein-containing powders, wherein the proportion of phenylalanine is at least 30% (w/w), or at least 40% (w/w). It has been shown that phenylalanine-containing powders, particularly after spray drying, are very suitable in terms of their aerodynamic characteristics and protein stabilization for preparing powders or protein compositions with improved aerodynamic properties. The main component is phenylalanine and the optional further component is an excipient which has good water-solubility compared with phenylalanine, preferably a sugar or a polyol.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: July 24, 2012
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Torsten Schultz-Fademrecht, Patrick Garidel, Beate Fischer, Karoline Bechtold-Peters
  • Publication number: 20100220187
    Abstract: The invention relates to the optical measurement of fill level in the aseptic bottling or packaging of biopharmaceuticals. The process according to the invention allows in particular in-process fill level measurement of primary packaging means filled with protein solution with small volumes and with considerable variations in the packaging means. The invention also relates to an apparatus according to FIG. 5B.
    Type: Application
    Filed: December 4, 2009
    Publication date: September 2, 2010
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Christina LICHTBLAU, Stefan BASSARAB, Karoline BECHTOLD-PETERS, Christian BRADER
  • Patent number: 7727962
    Abstract: The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-Glu-saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu-saccharose (maltosyl sucrose) in combination with at least one further excipient. The other excipient is preferably an amino acid, a peptide and/or a mono-, di- and/or oligosaccharide, wherein the oligosaccharide may be a second 1,4 O-linked saccharose derivative, provided that this is different from the first.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: June 1, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Patent number: 7723306
    Abstract: The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are such that they contain glucosyl and maltosyl sucrose.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: May 25, 2010
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Patent number: 7611709
    Abstract: Disclosed are applications of oligosaccharides/oligosaccharide mixtures for the production and stabilization of pharmaceutical compositions, chiefly powders, that contain antibodies or antibody derivatives as pharmaceutical active substance. The production of powders is accomplished through spray drying or freeze drying. Also disclosed are the corresponding antibody-containing powders as well as processes for their production.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: November 3, 2009
    Assignee: Boehringer Ingelheim Pharma GmbH and Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Publication number: 20090137621
    Abstract: The invention relates to capsules for inhalation (inhalettes) made from specific capsule materials with a reduced moisture content, which contain the active substance tiotropium in the form of powdered preparations and are characterised by increased stability.
    Type: Application
    Filed: October 9, 2008
    Publication date: May 28, 2009
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Dieter Hochrainer, Karoline Bechtold-Peters, Michael Trunk, Michael Walz
  • Publication number: 20080292563
    Abstract: The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: July 29, 2008
    Publication date: November 27, 2008
    Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG
    Inventors: Karoline BECHTOLD-PETERS, Michael WALZ, Georg BOECK, Rolf DOERR
  • Publication number: 20080089849
    Abstract: The invention therefore relates to protein-containing powders, wherein the proportion of phenylalanine is at least 30% (w/w), or at least 40% (w/w). It has been shown that phenylalanine-containing powders, particularly after spray drying, are very suitable in terms of their aerodynamic characteristics and protein stabilisation for preparing powders or protein compositions with improved aerodynamic properties. The main component is phenylalanine and the optional further component is an excipient which has good water-solubility compared with phenylalanine, preferably a sugar or a polyol.
    Type: Application
    Filed: June 22, 2007
    Publication date: April 17, 2008
    Inventors: Torsten SCHULTZ-FADEMRECHT, Patrick Garidel, Beate Fischer, Karoline Bechtold-Peters
  • Publication number: 20080071064
    Abstract: The invention relates to the controlled crystallisation of powders, particularly spray-dried powders, for improving the flowability and the aerodynamic characteristics thereof and a method of reducing the electrostatics of a powder.
    Type: Application
    Filed: June 22, 2007
    Publication date: March 20, 2008
    Inventors: Torsten SCHULTZ-FADEMRECHT, Patrick GARIDEL, Beate FISCHER, Karoline BECHTOLD-PETERS
  • Publication number: 20080057003
    Abstract: The present invention relates to new methods for the surface modification of powders. Furthermore the present invention relates to new, improved pharmaceutical dosage forms obtainable by the new methods for surface modification of drugs according to the invention and to the use of these pharmaceutical dosage forms within dry powder inhalation devices (DPI).
    Type: Application
    Filed: January 17, 2007
    Publication date: March 6, 2008
    Inventors: Karoline Bechtold-Peters, Geoffrey Rowley, Hanh Nguyen
  • Publication number: 20070298116
    Abstract: The present invention relates to spray-dried amorphous powders which contain a pharmaceutical active substance and a matrix-forming agent, preferably a polymer, sugar or sugar alcohol in an amount of ?20-60% (w/w). The powders have a moisture content which is less than 1.2% (w/w), preferably less than 1% (w/w). The present invention also relates to special methods of preparing such powders and methods of administering them by inhalation.
    Type: Application
    Filed: August 10, 2004
    Publication date: December 27, 2007
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Karoline Bechtold-Peters, Wolfgang Friess, Stefanie Schuele, Stefan Bassarab, Patrick Garidel, Torsten Schultz-Fademrecht
  • Patent number: 7070800
    Abstract: The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: July 4, 2006
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Karoline Bechtold-Peters, Michael Walz, Georg Boeck, Rolf Doerr
  • Publication number: 20060039868
    Abstract: The invention relates to powdered preparations containing tiotropium for inhalation, processes for preparing them as well as their use in preparing a pharmaceutical composition for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 23, 2006
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Karoline Bechtold-Peters, Michael Walz, Georg Boeck, Rolf Doerr
  • Publication number: 20050255119
    Abstract: The present invention relates to compositions, preferably powdered compositions such as spray-dried or freeze-dried powders, containing an antibody or and antibody derivative and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are those which contain lactosucrose or a combination of glucosyl and maltosyl sucrose.
    Type: Application
    Filed: May 2, 2005
    Publication date: November 17, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Publication number: 20050250704
    Abstract: The present invention concerns powders containing a pharmaceutical active substance and a combination of excipients comprising at least one 1,4 O-linked saccharose derivative selected from the compounds: 1,4 O-linked D-Gal-saccharose (lactosucrose), 1,4 O-linked D-Glu-saccharose (glucosyl sucrose), or 1,4 O-linked Glu-Glu-saccharose (maltosyl sucrose) in combination with at least one further excipient. The other excipient is preferably an amino acid, a peptide and/or a mono-, di- and/or oligosaccharide, wherein the oligosaccharide may be a second 1,4 O-linked saccharose derivative, provided that this is different from the first.
    Type: Application
    Filed: May 2, 2005
    Publication date: November 10, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Publication number: 20050250705
    Abstract: The present invention relates to a spray-dried powder and method for its manufacture. A spray dried powder containing a pharmaceutical active substance and one or more 1,4 O-linked saccharose derivatives chosen from the compounds: 1,4 O-linked D-gal-saccharose (lactosucrose), 1,4 O-linked D-glu-saccharose (glucosyl sucrose) or 1,4 O-linked glu-glu-saccharose (maltosyl sucrose). Preferred combinations are such that they contain glucosyl and maltosyl sucrose.
    Type: Application
    Filed: May 2, 2005
    Publication date: November 10, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH Co. KG
    Inventors: Stefan Bassarab, Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Patrick Garidel, Torsten Schultz-Fademrecht
  • Publication number: 20050196346
    Abstract: The present invention relates to new methods for the surface modification of powders. Furthermore the present invention relates to new, improved pharmaceutical dosage forms obtainable by the new methods for surface modification of drugs according to the invention and to the use of these pharmaceutical dosage forms within dry powder inhalation devices (DPI).
    Type: Application
    Filed: March 30, 2005
    Publication date: September 8, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Karoline Bechtold-Peters, Geoffrey Rowley, Hanh Nguyen
  • Publication number: 20050191246
    Abstract: Disclosed are powders, preferably spray-dried powders, which contain a pharmaceutical active substance and low-molecular dextran as excipient. Also disclosed are processes for preparing such powders and methods of administering them by inhalation.
    Type: Application
    Filed: November 30, 2004
    Publication date: September 1, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Karoline Bechtold-Peters, Richard Fuhrherr, Wolfgang Friess, Stefan Bassarab, Patrick Garidel, Torsten Schultz-Fademrecht
  • Publication number: 20050084457
    Abstract: The invention relates to capsules for inhalation (inhalettes) made from specific capsule materials with a reduced moisture content, which contain the active substance tiotropium in the form of powdered preparations and are characterised by increased stability.
    Type: Application
    Filed: July 29, 2004
    Publication date: April 21, 2005
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Dieter Hochrainer, Karoline Bechtold-Peters, Michael Trunk, Michael Walz