Patents by Inventor Karoly Kocsis
Karoly Kocsis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4467101Abstract: Acylamido-3-cephem-4-carboxylic acid compounds of the formula ##STR1## in which the index n represents an integer of from 1 to 4,the index m represents 0 or 1,X represents oxygen, sulphur or an --NH-- group,W represents a --CO--, --CO--NHSO.sub.2 -- or --SO.sub.2 NH--CO-- group, orX-W together represent a --CO-- or --CO--NHSO.sub.2 -- group,A represents optionally substituted phenylene, thienylene or furylene,Y represents hydrogen, hydroxyl, formyloxy, amino or sulpho optionally present in salt form, andZ represents hydrogen, orY and Z together represent an oxo group or an .dbd.N--O--R.degree. group in which R.degree. represents hydrogen or optionally substituted lower alkyl,R.sub.1 represents hydrogen, lower alkyl, lower alkoxy, halogen or a group of the formula --CH.sub.2 --R.sub.2 in which R.sub.2 is a free, esterified or etherified hydroxy or mercapto group or a quaternary ammonium group, andR.sub.Type: GrantFiled: September 20, 1982Date of Patent: August 21, 1984Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Peter Schneider, Bruno Fechtig, Riccardo Scartazzini
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Patent number: 4464366Abstract: Compounds of the formula ##STR1## in which the index n represents an integer of from 1 to 4,the index m represents 0 or 1,X represents oxygen, sulphur or the group --NH--,W represents a group --CO--, --CO--NHSO.sub.2 -- or --SO.sub.2 NH--CO--,or X-W together represent a group --CO-- or --CO--NHSO.sub.2 --,A represents optionally substituted phenylene, thienylene or furylene,Z represents oxygen or sulphur,Y represents lower alkylene,the index k represents the value 1 or 2,R.sub.4 represents hydrogen, an optionally substituted lower aliphatic or cycloaliphatic radical or acyl,R.sub.1 represents hydrogen, lower alkyl, lower alkoxy, halogen or a group of the formula --CH.sub.2 --R.sub.2 in which R.sub.2 represents a free, esterified or etherified hydroxy or mercapto group or a quaternary ammonium group, andR.sub.Type: GrantFiled: December 8, 1980Date of Patent: August 7, 1984Assignee: Ciba Geigy CorporationInventors: Hansuli Wehrli, Karoly Kocsis, Riccardo Scartazzini
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Patent number: 4374134Abstract: Acylamido-3-cephem-4-carboxylic acid compounds of the formula ##STR1## in which the index n represents an integer of from 1 to 4,the index m represents 0 or 1,X represents oxygen, sulphur or an --NH-- group,W represents a --CO--, --CO--NHSO.sub.2 -- or --SO.sub.2 NH--CO-- group, orX-W together represent a --CO-- or --CO--NHSO.sub.2 -- group,A represents optionally substituted phenylene, thienylene or furylene,Y represents hydrogen, hydroxyl, formyloxy, amino or sulpho optionally present in salt form, andZ represents hydrogen, orY andZ together represent an oxo group or an .dbd.N--O--R.sup.o group in which R.sup.o represents hydrogen or optionally substituted lower alkyl,R.sub.1 represents hydrogen, lower alkyl, lower alkoxy, halogen or a group of the formula --CH.sub.2 --R.sub.2 in which R.sub.2 is a free, esterified or etherified hydroxy or mercapto group or a quaternary ammonium group, andR.sub.Type: GrantFiled: February 11, 1980Date of Patent: February 15, 1983Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Peter Schneider, Bruno Fechtig, Riccardo Scartazzini
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Patent number: 4265892Abstract: Compounds of the formula ##STR1## wherein R.sub.1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R.sub.2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R.sub.3 represents hydrogen, lower alkoxy or an optionally substituted methyl group and B represents an optionally substitued six-membered ring with 1 to 3 ring nitrogen atoms, which is bonded to the carbonyl group --C(.dbd.O)-- by one of its carbon atoms, the nitrogen atoms of a monocyclic six-membered ring having 2 nitrogen atoms being either adjacent or separated by two ring carbon atoms, and the salts of such compounds which have a salt-forming group, including the inner salts, for example the 7.beta.-[D(-)-.alpha.-(3,5-Dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-c arboxamido)-phenylacetamido]-cephalosporanic acid, have antibiotic activity.Type: GrantFiled: February 12, 1979Date of Patent: May 5, 1981Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Heinrich Peter, Hans Bickel
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Patent number: 4202900Abstract: 6-Acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##STR1## in which R.sub.1 is hydrogen, R.sub.2 is optionally substituted phenyl, thienyl or furyl or R.sub.1 and R.sub.2 together are optionally substituted cycloalkyl, n and m independently of one another represent 0 or 1 and B represents an optionally substituted 2,6-dioxo- or 2,6-dithioxo-1,2,3,6-tetrahydro-pyrimidyl, 2-thioxo-6-oxo-1,2,3,6-tetrahydropyrimidyl, 2,6-dihydroxy- or 2,6-dimercapto-pyrimidyl, 2-mercapto-6-hydroxy-pyrimidyl, 2,6-diaminopyrimidyl, 2-amino-6-hydroxy-pyrimidyl or 2,6-dihalogenopyrimidyl radical, these radicals being bonded in the 4- or 5-position.Type: GrantFiled: April 28, 1978Date of Patent: May 13, 1980Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Bruno Fechtig, Hans Bickel
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Patent number: 4154831Abstract: Compounds of the formula ##STR1## wherein R.sub.1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R.sub.2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R.sub.3 represents hydrogen, lower alkoxy or an optionally substituted methyl group and B represents an optionally substituted six-membered ring with 1 to 3 ring nitrogen atoms, which is bonded to the carbonyl group --C(.dbd.O)-- by one of its carbon atoms, the nitrogen atoms of a monocyclic six-membered ring having 2 nitrogen atoms being either adjacent or separated by two ring carbon atoms, and the salts of such compounds which have a salt-forming group, including the inner salts, for example the 7.beta.-[D(-)-.alpha.-(3,5-Dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-c arboxamido)-phenylacetamido]-cephalosporanic acid, have antibiotic activity.Type: GrantFiled: April 20, 1977Date of Patent: May 15, 1979Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Heinrich Peter, Hans Bickel
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Patent number: 4115566Abstract: 6-Acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##STR1## in which R.sub.1 is hydrogen, R.sub.2 is optionally substituted phenyl, thienyl or furyl, or R.sub.1 and R.sub.2 together are optionally substituted cycloalkyl, and B is a radical which is bonded via a sulphur atom or is bonded to oxygen or sulphur with the interposition of an optionally substituted CH.sub.2 -group.Type: GrantFiled: December 19, 1975Date of Patent: September 19, 1978Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Bruno Fechtig, Hans Bickel
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Patent number: 4067979Abstract: The invention relates to compounds of the formula ##STR1## wherein R.sub.1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R.sub.2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R.sub.3 represents hydrogen, lower alkoxy or an optionally substituted methyl group, and B represents a monosubstituted or polysubstituted six-membered ring with 1 to 3 ring nitrogen atoms which is bonded to the carbonyl group --C(.dbd.O)-- by one of its ring carbon atoms, and the salts of such compounds which have salt-forming groups, which compounds possess antibiotic properties.Type: GrantFiled: April 7, 1975Date of Patent: January 10, 1978Assignee: Ciba-Geigy CorporationInventors: Hans Bickel, Karoly Kocsis, Heinrich Peter
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Patent number: 4041161Abstract: Compounds of the formula ##STR1## wherein R.sub.1 denotes optionally substituted phenyl, thienyl, furyl or 1,4-cyclohexadienyl, R.sub.2 represents a free carboxyl group or an esterified carboxyl group which can be split physiologically, R.sub.3 represents hydrogen, lower akoxy or an optionally substituted methyl group and B represents an optionally substituted six-membered ring with 1 to 3 ring nitrogen atoms, which is bonded to the carbonyl group --C(.dbd.O)-- by one of its carbon atoms, the nitorgen atoms of a monocyclic six-membered ring having 2 nitrogen atoms being either adjacent or separated by two ring carbon atoms, and the salts of such compounds which have a salt-forming group, including the inner salts, for example the 7.beta.-[D(-)-.alpha.-(3,5-Dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbo xamido)-phenylacetamido]-cephalosporanic acid, have antibiotic activity.Type: GrantFiled: May 9, 1975Date of Patent: August 9, 1977Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Heinrich Peter, Hans Bickel
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Patent number: 4015000Abstract: 6-Acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##STR1## IN WHICH R.sub.1 is hydrogen, R.sub.2 is optionally substituted phenyl, thienyl or furyl or R.sub.1 and R.sub.2 together are optionally substituted cycloalkyl, n and m independently of one another represent 0 or 1 and B represents an optionally substituted 2,6-dioxo- or 2,6-dithioxo-1,2,3,6-tetrahydro-pyrimidyl, 2-thioxo-6-oxo-1,2,3,6-tetrahydropyrimidyl, 2,6-dihydroxy- or 2,6-dimercapto-pyrimidyl, 2-mercapto-6-hydroxy-pyrimidyl, 2,6-diaminopyrimidyl, 2-amino-6-hydroxy-pyrimidyl or 2,6-dihalogenopyrimidyl radical, these radicals being bonded in the 4- or 5-position.Type: GrantFiled: September 18, 1973Date of Patent: March 29, 1977Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Bruno Fechtig, Hans Bickel
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Patent number: 3996208Abstract: 6-acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##STR1## in which R.sub.1 is hydrogen, R.sub.2 is optionally substituted phenyl, thienyl or furyl or R.sub.1 and R.sub.2 together are optionally substituted cycloalkyl, and R is a radical which is linked through a carbon, oxygen, sulphur or nitrogen atom.Type: GrantFiled: March 21, 1973Date of Patent: December 7, 1976Assignee: Ciba-Geigy CorporationInventors: Bruno Fechtig, Karoly Kocsis, Hans Bikel
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Patent number: 3954802Abstract: 6-Acylamino-penam-3-carboxylic acids and 7-acylamino-3-cephem-4-carboxylic acids in which the acyl group has the formula ##EQU1## in which R.sub.1 is hydrogen, R.sub.2 is optionally substituted phenyl, thienyl or furyl, or R.sub.1 and R.sub.2 together are optionally substituted cycloalkyl, and B is a radical which is bonded via a sulphur atom or is bonded to oxygen or sulphur with the interposition of an optionally substituted CH.sub.2 -group.Type: GrantFiled: March 22, 1973Date of Patent: May 4, 1976Assignee: Ciba-Geigy CorporationInventors: Karoly Kocsis, Bruno Fechtig, Hans Bickel