Patents by Inventor Karoly Magyar
Karoly Magyar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5254547Abstract: The invention relates to new thioacid amide derivatives, a process for the preparation thereof, compositions, particularly feed additives, premixes and ready-for-use fodders, comprising the same, further to a method for increasing weight gain and improving fodder utilization of domestic animals.The new thioacid amide derivatives of the general formula (I), whereinR represents hydrogen, C.sub.1-18 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl andR.sup.1 stands for hydrogen, halogen or methoxy, with the provisos thata) at least one of R and R.sup.1 is other than hydrogen;b) if R represents ethyl, R.sup.1 is other than hydrogen; andc) if R stands for methyl, R.sup.1 is other than hydrogen or methoxy,exhibit useful weight-gain increasing and fodder-utilization improving effects and can be used in animal husbandry, particularly in pig.Type: GrantFiled: December 4, 1991Date of Patent: October 19, 1993Assignee: EGIS GyogyszergyarInventors: Zoltan Budai, Tibor Mezei, Klara Reiter nee Esses, Lajos Fekete, Karoly Magyar, Attila Nagy, Laszlo Puskas
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Patent number: 5221673Abstract: This invention relates to fodder compositions, particularly feed additives, premixes and ready-for-use fodders, and a method for increasing weight-gain and improving fodder utilization of dimestic animals.The compositions according to the invention comprise as active ingredient a compound of the general formula (I), ##STR1## wherein R.sup.1 represents methoxy or hydrogen andR stands for methyl; orR and R.sup.1 each denotes hydrogen; orR.sup.1 stands for hydrogen and R represents ethyl.The compounds of the general formula (I) known from the literature exhibit useful weight-gain increasing and fodder-utilization improving effects and can be used in animal husbandry.Type: GrantFiled: December 4, 1991Date of Patent: June 22, 1993Assignee: Egis GyogyszergyarInventors: Zoltan Budai, Tibor Mezei, Klara Reiter nee Esses, Lajos Fekete, Karoly Magyar, Attila Nagy, Laszlo Puskas
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Patent number: 5120711Abstract: The invention relates to synergistically active veterinary compositions useful particularly for the treatment of mastitis and metritis. The invention further relates to a process for preparing these compositions. The compositions according to the invention comprise, based on 1 part by weight of 6,9,18-tris(2-aminoethyl) -15-benzyl-21-[.sup.- 2,8-bis(2-aminoethyl)-5-(1-hydroxyethyl) -15-methyl-4,7,10-trioxo-3,6,9-triazaheptadecanamido]-3-(1-hydroxyethyl)-1 2-isobutyl-1,4,7,10,13,16,19-heptaazacyclotricosane-2, 5,8,11,14,17,20-heptaone or a pharmaceutically acceptable acid addition salt thereof, 1 to 1000 parts by weight of 1-(2-chlorophenyl)-diphenylmethyl-1H-imidazole or 1 to 400 parts by weight of 2-methyl-5,7-dichloro-8-hydroxyquinoline, respectively, optionally in admixture with carriers and/or additives commonly used in the pharmaceutical industry.Type: GrantFiled: November 20, 1990Date of Patent: June 9, 1992Assignee: EGIS GyogyszergyarInventors: Karoly Magyar, Ferenc Simon, Janos Varga, Attila Nagy, Laszlo Puskas, Pal Fekete, Janos Egri, Katalin Zukovics
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Patent number: 5047434Abstract: The invention relates to weight gain-increasing compositions, particularly fodder supplement, premix, drinking water supplement, bolus and/or microcapsule containing 0.001 to 90% by weight of 1-(3,5-dihydroxyphenyl)-2-(tertiary butylamino)-ethanol or a physiologically acceptable acid addition salt thereof as active ingredient in admixture with inert solid and/or liquid carrier(s).Type: GrantFiled: July 5, 1989Date of Patent: September 10, 1991Assignee: Egis GyogyszergyarInventors: Ferenc Simon, Karoly Magyar, Attila Nagy, Lajos Fekete, Laszlo Puskas, Pal Fekete, Istvan Simonyi, Janos Egri, Katalin Zukovics nee Sumeg
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Patent number: 4921854Abstract: The compounds of the general formula I ##STR1## and pharmaceutically acceptable acid addition salts and hydrates thereof possess useful immunostimulant properties and can be used in therapy.In the general Formula IA stands for --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 CH.sub.2 --or --CH.dbd.CH--;R.sub.4 is hydrogen, C.sub.1-4 alkyl or optionally substituted phenyl;r is 0, 1, 2, 3 or 4;R.sub.1 stands for hydrogen of C.sub.1-5 alkanoyl;R.sub.2 represents hydrogen, C.sub.1-5 alkanoyl or a group of the general formula (a) ##STR2## wherein R stands for hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, phenyl or phenyl-C.sub.1-3 alkyl andR.sub.3 stands for hydrogen.The compounds of the general Formula I can be prepared by reacting a 2-mercapto-4,6-diamino-pyrimidine of the general Formula II ##STR3## with a dihalo compound of the general Formula III ##STR4## (wherein Y and Z are halogen).Type: GrantFiled: December 22, 1987Date of Patent: May 1, 1990Assignee: Egis GyogyszergyarInventors: Daniel Bozsing, Gyorgyi nee Lax Kovanyi, Edit nee Poldermann Berenyi, Karoly Magyar, Sandor Tuboly, Atti la Mandi
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Patent number: 4883907Abstract: The present invention relates to new carbazates of the formula (I) ##STR1## wherein A is C.sub.3 to C.sub.10 alkenyl, C.sub.2 to C.sub.10 haloalkyl, trifluoromethyl, phenyl-C.sub.1 to C.sub.3 alkyl, phenyl-C.sub.2 to C.sub.3 alkenyl, naphthyl-C.sub.1 to C.sub.3 alkyl, C.sub.3 to C.sub.7 cycloalkyl-C.sub.1 to C.sub.3 alkyl, furyl which can be nitro-substituted, diphenyl-hydroxymethyl or indazolyl which can be substituted by one or more C.sub.1 to C.sub.4 alkoxy groups; andR is C.sub.1 to C.sub.4 alkyl,and acid addition salts thereof, a process for the preparation thereof and feed additives comprising the same.The compounds of formula (I) may be used in animal husbandry due to their weight-gain increasing and fodder utilization improving effect.Type: GrantFiled: April 11, 1988Date of Patent: November 28, 1989Assignee: Egis GyogyszergyarInventors: Ildiko Ratz nee Simonek, Pal Benko, Edit Berenyi nee Foldermann, Karoly Magyar
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Patent number: 4871722Abstract: The invention relates to a synergistic veterinary composition and/or a fodder premix useful for preventing or curing bacterial, fungal and protozoic infection particularly occurring at poultry species. Furthermore the invention relates to a process for preparing same. The composition or premix contains 1 to 100 parts by mass of 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine and/or 1 to 100 parts by mass of 2,4-diamino-5-(3,4-dimethoxybenzyl)pyrimidine as well as 1 to 100 parts by mass of 2,6-dimethoxy-4-sulfanilamidopyrimidine or a pharmaceutically acceptable salt thereof and 1 to 100 parts by mass of 8-hydroxyquinoline or a pharmaceutically acceptable acid addition salt thereof optionally in admixture with carrier(s) and/or additive(s) commonly used in the pharmaceutical industry or for the preparation of premixes.Type: GrantFiled: February 22, 1988Date of Patent: October 3, 1989Assignee: EGIS GyogyszergvarInventors: Karoly Magyar, Janos Varga, Ferenc Simon, Hedvig Szauder nee Lauko, Pal Fekete, Attila Romvary, Janos Egri, Katalin Zukovics nae Someg
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Patent number: 4824670Abstract: The present invention relates to new carbazates of the general formula (I), ##STR1## wherein A is C.sub.3-10 alkyl, C.sub.3-10 alkenyl, C.sub.2-10 haloalkyl, trifluoromethyl, phenyl-C.sub.1-3 alkyl, phenyl-C.sub.2-3 -alkenyl, naphthyl-C.sub.1-3 alkyl; phenyl optionally substituted by one or more identical or different substituent(s) selected from C.sub.1-4 alkyl, halogen, C.sub.1-4 alkoxy and hydroxy; C.sub.3-7 cycloalkyl-C.sub.1-3 alkyl; optionally nitro-substituted furyl; diphenyl-hydroxy-methyl or indazolyl optionally substituted by one or more C.sub.1-4 alkoxy group(s) andR represents C.sub.1-4 alkyl,with the proviso that if R stands for ethyl, A is other than tertiary butyl, and acid addition salts thereof, a process for the preparation thereof and feed-additives comprising the same.The compounds of the general formula (I) may be used in animal husbandry due to their weight-gain increasing and fodder utilization improving effect.Type: GrantFiled: December 11, 1985Date of Patent: April 25, 1989Assignee: Egis GyogyszergyarInventors: Ildiko Ratz nee Simonek, Pal Benko, Edit Bernenyi nee Poldermann, Karoly Magyar
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Patent number: 4774090Abstract: The invention relates to a microencapsulated insecticidal composition containing isopropyl (2E,4E)-3,7,11-trimethyl-11-methoxy-2,4-dodecaidenoate which comprises 45-95% by weight of isopropyl (2E,4E)-3,7,11-trimethyl-11-methoxy-2,4-dodecadenoate as active ingredient, 1-15% by weight of butyl hydroxy toluene and 5-40% by weight of activated charcoal, in the form of powdery microcapsules having a grain size of 1-300 .mu.m and coated with a hydroxypropyl methyl cellulose phthalate or cellulose acetate phthalate polymer.The advantage of the microencapsulated insectidical composition according to the present invention resides in the increased stability.Type: GrantFiled: December 2, 1983Date of Patent: September 27, 1988Assignee: Egyt Gyogyszervegyeszeti GYARInventors: Pal Fekete, Karoly Magyar, Anna Mayer nee Almasi, Jozsef Kelemen, Katalin Toth
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Patent number: 4680315Abstract: The invention refers to a powder mixture having a high propylene glycol content and a process for the preparation thereof. The powder mixture consists of 25 to 75 percent by weight of propylene glycol and 75 to 25 percent by weight of magnesium oxide and/or magnesium peroxide and/or magnesium carbonate as a solid carrier(s). The powder mixture can be treated as a solid powder and it does not deliquesce in the air even when stored for a long time. The mixture can be used as solid propylene glycol in dietetic products for calf, piglet and lamb, in pharmaceutical compositions for the treatment of ketosis and in other pharmaceutical compositions for veterinary use.Type: GrantFiled: January 7, 1985Date of Patent: July 14, 1987Assignee: EGYT Gyogyszervegyeszeti GyarInventors: Denes Bezzegh, Karoly Magyar, Jozsef Kelemen, Gabor Zalai, Attila Mandi, Janos Egri
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Patent number: 4618623Abstract: The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same. The new compounds according to the invention correspond to the formula (I)R.sup.1 .dbd.N--NH--COOR.sup.3 (I)wherein R.sup.1 stands for a C.sub.7-12 cycloalkylidene group, an indanylidene group or a group of the formula (IX) ##STR1## wherein A represents a phenyl group optionally carrying one or more identical or different substituents selected from the group consisting of halo, nitro, hydroxy, C.sub.1-4 alkoxy, C.sub.1-4 alkyl, amino or C.sub.1-4 alkoxycarbonylhydrazino; phenyl-(C.sub.1-4 alkyl), C.sub.1-16 alkyl, C.sub.3-7 cycloalkyl or indolyl, or a C.sub.3 -C.sub.6 cycloalkyl group substituted by a C.sub.3 -C.sub.6 cycloalkyl group; R.sup.2 denotes a hydrogen atom, a C.sub.1-16 alkyl or a C.sub.3-7 cycloalkyl group; and R.sup.3 represents a C.sub.1-4 alkyl group.Type: GrantFiled: May 23, 1985Date of Patent: October 21, 1986Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Pal Benko, Ildiko Ratz nee Simonek, Eva Rakoczy nee Pinter, Karoly Magyar, Jozsef Kelemen, Attila Mandi
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Patent number: 4587261Abstract: The invention relates to new cycloalkane derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same.The new compounds of the present invention correspond to the general formula I ##STR1## wherein n is 3, 4, 5 or 6;R denotes a phenyl group optionally carrying one or more substituent/s/ selected from the group consisting of halogen, lower alkoxy and lower alkyl;R.sup.1 and R.sup.2 each represent hydrogen or form together a valence bond;R.sup.3 represents lower alkoxy or a phenyl optionally substituted by one or more C.sub.1-12 alkoxy.The fodder additives and fodders according to the invention contain as active ingredient an amount of 1 ppm to 85% by weight of a compound of the general formula I in admixture with inert solid or liquid carriers or diluents and can be used to advantage in animal husbandry.Type: GrantFiled: May 3, 1983Date of Patent: May 6, 1986Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Pal Benko, Ildiko Ratz nee Simonek, Eva Rakoczy nee Pinter, Karoly Magyar, Jozsef Kelemen, Attila Mandi
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Patent number: 4570002Abstract: The invention relates to new carbazic acid derivatives, a process for the preparation thereof and compositions--particularly feed additives and animal feeds--containing the same.The new compounds according to the invention correspond to the formula (I)R.sup.1 .dbd.N--NH--COOR.sup.3 (I)whereinR.sup.1 stands for a C.sub.7-12 cycloalkylidene group, an indanylidene group or a group of the formula (IX) ##STR1## wherein A represents a phenyl group optionally carrying one or more identical or different substituents selected from the group consisting of halo nitro, hydroxy, C.sub.1-14 alkoxy, C.sub.1-4 alkyl, amino or C.sub.1-4 alkoxycarbonylhydrazino; phenyl-(C.sub.1-4 alkyl), C.sub.1-16 alkyl, C.sub.3-7 cycloalkyl or indolyl or a C.sub.3 -C.sub.6 cycloalkyl group substituted by a C.sub.3 -C.sub.6 cycloalkyl group;R.sup.2 denotes a hydrogen atom, a C.sub.1-16 alkyl or a C.sub.3-7 cycloalkyl group; andR.sup.3 represents a C.sub.1-4 alkyl group.Type: GrantFiled: January 24, 1984Date of Patent: February 11, 1986Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Zoltan Budai, Pal Benko, Ildiko Ratz nee Simonek, Eva Rakoczy nee Pinter, Karoly Magyar, Jozsef Kelemen, Attila Mandi
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Patent number: 4511717Abstract: The invention relates to new 2-hydroxymethyl-quinoxaline-1,4-dioxide derivatives of the general formula (I) ##STR1## wherein A represents an amino group, or a group of the general formula --NH--COOR.sub.1, wherein R.sub.1 stands for a C.sub.2-4 alkyl group, or a group of the general formula --NH--CX--NH.sub.2, whereinX denotes an oxygen or sulfur atom, or a group of the formula --NH--C(NH)--NH.sub.2, or a group of the general formula --NH--R.sub.2, wherein R.sub.2 represents a C.sub.1-6 alkyl, a phenyl, a benzyl, a hydroxyl or a hydroxy-(C.sub.2-4 alkyl) group, or a group of the general formula --NH--CO--R.sub.3, wherein R.sub.3 stands for a C.sub.1-20 alkyl group or a phenyl group optionally substituted by one, two or three identical or different substituent(s) selected from the group consisting of nitro, hydroxyl, amino, C.sub.1-3 alkoxy and halogen; a naphtyl group optionally substituted by a hydroxyl group, a phenyl-(C.sub.Type: GrantFiled: March 27, 1984Date of Patent: April 16, 1985Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Ildiko Ratz nee Simonek, Laszlo Pallos, Karoly Magyar, Jeno Kovacs, Erzsebet Matrai, Janos Gundel, Albert Balogh
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Patent number: 4409219Abstract: The invention relates to new quinoxaline-1,4-derivatives of the general formula (I) and biologically acceptable salts thereof, ##STR1## wherein Q is a hydrogen atom or a methyl group,R.sub.1 represents a hydrogen atom, a cyano, lower alkanoyl or nitro group or a halogen atom,R.sub.2 stands for cyano, lower alkanoyl, or a group of the general formula --COOR.sub.3, --CONR.sub.4 R.sub.5 or --CO--NH--NR.sub.4 R.sub.5, andR.sub.3 represents a hydrogen atom or a C.sub.1-18 alkyl, C.sub.6-12 aryl or C.sub.6-10 aryl-(C.sub.1-14 alkyl) group optionally substituted by a halogen atom or a hydroxy group, whereby the aromatic ring of the said groups may optionally contain 1-3 identical or different substituents selected from the group consisting of lower alkyl or alkoxy, amino, nitro, halogen and/or hydroxy,R.sub.4 is a hydrogen atom or a C.sub.1-18 alkyl, a lower alkenyl, a lower alkynyl, a lower cycloalkyl, C.sub.6-10 aryl, C.sub.6-10 aryl-(C.sub.Type: GrantFiled: May 22, 1981Date of Patent: October 11, 1983Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Daniel Bozsing, Jamos Gundel, Karoly Magyar
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Patent number: 4404204Abstract: The invention relates to fodder concentrates, fodder additives and fodders having antimicrobial and/or weight-gain increasing effects which comprise as active ingredient a new compound of the general formula (I) ##STR1## wherein R represents a C.sub.1-20 alkyl, a C.sub.1-6 alkoxy group, an optionally substituted C.sub.6-10 aryl group, a phenyl-(C.sub.1-3 alkyl), a C.sub.3-7 cycloalkyl or a 5 or 6 membered heterocyclic group containing one or two nitrogen and/or oxygen and/or sulfur atom(s),or a biologically acceptable acid addition salt of a basic compound of the general formula (I) together with a suitable inert, solid or liquid carrier or diluent.The invention relates also to the preparation of the new compounds of the general formula (I).Type: GrantFiled: June 19, 1981Date of Patent: September 13, 1983Assignee: Patentbureau DANUBIAInventors: Pal Benko, Daniel Bozsing, Janos Gundel, Karoly Magyar
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Patent number: 4373101Abstract: The invention relates to novel quinoxaline-2-yl ethenyl ketones, their preparation and compositions containing them.The novel quinoxaline-2-yl ethenyl ketones of the general formula I ##STR1## wherein R.sub.1 represents an aryl group or a heterocyclic group comprising one or more nitrogen and/or oxygen and/or sulfur atoms wherein both the aryl and heterocyclic groups are optionally substituted by one or more identical or different substituents,R.sub.2 stands for a hydrogen atom or a C.sub.1-4 alkyl group, are prepared by reacting an acetylquinoxaline derivative of the general formula II ##STR2## wherein R.sub.2 is as stated above, with an aldehyde of the general formula IIIR.sub.1 --CHO (III)wherein R.sub.1 is as stated above.The novel compounds of the general formula I possess valuable antibacterial effect and promote the growth of animals. Thus, the novel compounds can be incorporated in animal feeds.Type: GrantFiled: June 2, 1981Date of Patent: February 8, 1983Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Daniel Bozsing, Janos Gundel, Karoly Magyar
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Patent number: 4373100Abstract: The invention relates to fodder additives, fodder concentrates and fodders with weight gain increasing and fodder utilization improving effects, which contain as active agent a new compound of the general formula (I), ##STR1## The invention also relates to a process for the preparation of compounds having the general formula (I) by reacting a compound of the general formula (II), ##STR2## wherein Z is oxygen atom or represents two lower alkoxy groups and R.sup.1 is as defined above, with a compound of the general formula (III), ##STR3## wherein Q, A, B and n are as defined above, and, if desired, converting the resulting compound of the general formula (I) into another compound of the general formula (I) by well-known reactions.The compounds of the general formula (I) are new.Type: GrantFiled: June 2, 1981Date of Patent: February 8, 1983Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Daniel Bozsing, Janos Gundel, Karoly Magyar
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Patent number: 4097668Abstract: The invention provides 2-?(p-methoxy-benzoyl)-hydrazono-formyl!-quinoxaline-1,4-dioxide.This compound is indicated for use as a potent antibacterial agent having a low toxicity.Type: GrantFiled: March 9, 1977Date of Patent: June 27, 1978Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Ildiko Simonek, Laszlo Pallos, Jeno Kovacs, Karoly Magyar
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Patent number: 4091206Abstract: The invention relates to new quinoxaline-1,4-dione derivatives of the formula ##STR1## wherein R is pyridyl, 5-nitrofuryl or 1-naphthylmethyl group. The new compounds of formula I have weight-gain increasing effects.Type: GrantFiled: March 9, 1977Date of Patent: May 23, 1978Assignee: Egyt Gyogyszervegyeszeti GyarInventors: Pal Benko, Ildiko Simonek, Laszlo Pallos, Jeno Kovacs, Karoly Magyar