Abstract: The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr; screening methods for identifying compounds that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr; and compounds identified by the screening methods. The compounds are useful for treating a lentiviral infection. The present invention further provides methods of inducing loss of the lentiviral protein Vpr; methods of inhibiting lentivirus viral replication; and methods of treating a lentivirus infection in an individual. The methods generally involve administering to an individual infected with the lentivirus an effective amount of a compound that induces Vpr loss and/or that inhibits PPIase activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr.

Abstract: The present invention provides screening methods for identifying a compound that induces loss of the lentiviral protein Vpr; screening methods for identifying compounds that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr; and compounds identified by the screening methods. The compounds are useful for treating a lentiviral infection. The present invention further provides methods of inducing loss of the lentiviral protein Vpr; methods of inhibiting lentivirus viral replication; and methods of treating a lentivirus infection in an individual. The methods generally involve administering to an individual infected with the lentivirus an effective amount of a compound that induces Vpr loss and/or that inhibits PPIase activity of a protein that catalyzes cis-trans isomerization of cis-peptidylprolyl bonds in Vpr.

Abstract: A cut-and-close device for pressure pipes in production and supply installations for gaseous and liquid media includes a two-piece clamping block. A pipe-cutting and pipe-closing plate is driven into said clamping block by means of a propelling charge and a piston, both of which form part of a drive unit. The clamping block (1) is divided in the middle of its circular opening into a rear part (1.1) and a front part (1.2). The rear part (1.1) and the front part (1.2) can be screwed together. The rear part (1.1) and the front part (1.2) have rectangular slits (3) on the inside. The front part (1.2) also possesses a slot opening (5) large enough for a shearing plate (6). The shearing plate (6) runs in guide grooves (16) of a connector (12) bolted to the front part (1.2) of the clamping block (1). The conductor (12) is attached to the drive unit consisting of a pressure cylinder (13), a piston (14), and a cartridge furnishing a remotely triggered propelling charge.