Abstract: A flow cell, for detecting a fluidic sample separated by a sample separation apparatus, includes a cuvette, a flow channel formed at least partially in the cuvette and configured to enable a flow of the separated fluidic sample through the flow channel, an electromagnetic radiation inlet at which an excitation electromagnetic radiation beam is couplable into the cuvette, and an electromagnetic radiation outlet at which an emission electromagnetic radiation beam, generated by an interaction between the excitation electromagnetic radiation beam and the separated fluidic sample, is couplable out of the cuvette. A geometry of the cuvette is configured so that at least one point at the excitation backside surface of the cuvette is outside of a direct field of view of the electromagnetic radiation outlet.

Abstract: A micromachined flow cell includes a substrate and a freestanding tube, delimiting a fluidic conduit therein and being integrally formed from material of the substrate.

Abstract: A fluid separation system for separating compounds of a sample fluid in a mobile phase comprises a detector adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal on the optical stimulus signal. The detector comprises a light source adapted to provide an output light beam as the optical stimulus signal. The light source comprises a plurality of light emitting elements each adapted to emit a light beam having a respective wavelength, and a diffracting element. The plurality of light emitting elements are arranged that emitted light beams impinging on the diffracting element in a respective angle dependent on the respective wavelength are diffracted by the diffracting element into the output light beam.

Abstract: A micromachined flow cell (100), comprising a substrate (102), and a freestanding tube (104) delimiting a fluidic conduit (800) therein and being integrally formed from material of the substrate (102).

Abstract: A sample detection apparatus for detecting a fluidic sample in a flow cell of a sample separation system, the sample detection apparatus comprising an electromagnetic radiation source having a chamber configured for generating a plasma, and an energy source configured for generating and directing an energy beam towards the plasma for heating the plasma so that the plasma emits primary electromagnetic radiation, and a detection path being arranged in a detection direction, wherein the detection direction is arranged angularly displaced with respect to a propagation direction of the energy beam, so that primary electromagnetic radiation propagating in the detection direction enters the detection path, wherein the detection path comprises an electromagnetic radiation detector configured for detecting secondary electromagnetic radiation being characteristic for the fluidic sample and resulting from an interaction between the fluidic sample and the primary electromagnetic radiation propagating in the detection dir

Abstract: A fluid separation system (10) for separating compounds of a sample fluid in a mobile phase comprises a detector (50) adapted to detect separated compounds by providing an optical stimulus signal to the sample fluid and receiving a response signal to the optical stimulus signal. The detector (50) comprises a light source (100) adapted to provide an output light beam (230) as the optical stimulus signal. The light source (100) comprises a plurality of light emitting elements (200, 200A, 200Z) each adapted to emit a light beam (210, 210A1, 210A2, 210Z1, 210Z2) having a respective wavelength, and a diffracting element (220). The plurality of light emitting elements (200, 200A, 200Z) are arranged that emitted light beams (210, 210A1, 210A2, 210Z1, 210Z2) impinging, on the diffracting element (220) are diffracted by the diffracting element (220) to form the output light beam (230).

Abstract: A microfluidic chip comprises a first substantially linear separation column having a first length, the first separation column comprising a first stationary phase particle density distribution along the first length; and a second substantially linear separation column having a second length connected in series with the first separation column, the second separation column comprising a second stationary phase particle density distribution along the second length.

Abstract: An integrated flow cell, the flow cell comprising a semiconductor substrate, and a fluidic conduit having an at least partially transparent semiconductor oxide tubing, wherein the semiconductor oxide tubing is formed with the semiconductor substrate.

Abstract: A coupling for bringing a first conduit in communication with a second conduit. Each of the conduits comprises an end to be coupled and each of the conduits is adapted for conducting a medium. The coupling has a housing and at least one aperture in said housing. The housing is adapted for introducing said first and second conduits into the housing. Furthermore, the coupling comprises a recess in the housing. The recess is adapted for partly receiving the ends of the first and second conduits. The coupling has a seal adapted for sealing the first and second conduits within the recess.

Abstract: A fluidic chip device adapted for processing a fluidic sample, the fluidic chip device comprising a substrate comprising a fluidic conduit for conducting the fluidic sample under pressure, and two reinforcing structures between which the substrate is arranged, wherein the two reinforcing structures are connected to one another to reinforce pressure resistance of the substrate.

Abstract: A microfluidic device comprising at least one inlet port, at least one flow path coupled to the inlet port, and at least one fluid separation element coupled to the flow path, wherein the fluid separation element comprises a packing material and is adapted for separating different components of a fluid, wherein the microfluidic device comprises at least one retaining device for keeping the packing material of the fluid separation element fixed in place and protecting the microfluidic device from debris polluting the analyte.

Abstract: A focusing unit for a fluidic system adapted for processing a mobile phase containing a fluidic sample, the fluidic system having a first processing element and a second processing element each for interacting with the mobile phase, wherein the mobile phase is to be conducted through the first and second processing elements, wherein the focusing unit is adapted for being coupled to an inlet of the second processing element and is adapted for modifying an elution strength of the mobile phase in order to spatially focus at least a portion of the fluidic sample in a region close to the inlet of the second processing element.

Abstract: A coupling for bringing a first conduit in communication with a second conduit. Each of the conduits comprises an end to be coupled and each of the conduits is adapted for conducting a medium. The coupling has a housing and at least one aperture in said housing. The housing is adapted for introducing said first and second conduits into the housing. Furthermore, the coupling comprises a recess in the housing. The recess is adapted for partly receiving the ends of the first and second conduits. The coupling has a seal adapted for sealing the first and second conduits within the recess.

Abstract: A microfluidic chip with at least one inlet port, with at least one microfluidic flow path coupled to the inlet port, and with at least one analytical element adapted for analyzing and/or separating components of a liquid within the flow path which is arranged within or adjacent to, and/or is coupled to the microfluidic flow path. The microfluidic chip is adapted to execute at least two processes in parallel.

Abstract: Devices comprising a mechanism for selectively diverting a portion of a mobile phase flowing through a mobile-phase transporting conduit to a fluid-transporting conduit comprising a stationary phase for separating sample components are disclosed, as well as systems and methods for using the same.

Abstract: A casing for an optical set-up is described, with the casing comprising a cutout adapted for accommodating an optical component, wherein the geometry of the cutout is adapted for mounting the optical component from the exterior of the casing, and wherein the geometry of the cutout is adapted for mechanically fastening the optical component by means of an elastic force exerted radially upon the outer surface of the optical component.

Abstract: A beam splitter has a support frame made of silicon that has a membrane inside made of silicon. The membrane has in particular openings with bridges formed between them. On the side of membrane facing the incident beam is an aluminum coating to increase the reflectability or degree of reflection of the membrane. An incident beam bundle contacts the beam splitter at angle of incidence &phgr;. A portion of the incident beam is reflected off the bridges, and the remaining portion of the beam freely passes through the openings. The beam is correspondingly divided into a reflective portion and transmitted portion.

Abstract: The described beam splitter (39) has a support frame (40) made of silicon that has a membrane (42) inside made of silicon. The membrane (42) has in particular openings (43) with bridges (43′) formed between them. On the side of membrane (42) facing the incident beam (47) is an aluminum coating to increase the reflectability or degree of reflection of the membrane (42). An incident beam bundle (47) contacts the beam splitter (39) at angle of incidence &phgr;. A portion (48) of the incident beam (47) is reflected off the bridges (43′), and the remaining portion (49) of the beam (47) freely passes through the openings (43). The beam is correspondingly divided into a reflective portion (48) and transmitted portion (49).

Abstract: The invention concerns a photodetector for detecting electromagnetic waves, especially in the UV range, and a method of forming it. The photodetector has at least one substrate layer consisting essentially of silicon. The substrate layer has a surface that is (1) at least partially covered with a cover layer transparent to electromagnetic waves and (2) covered by a cover layer surface. The cover layer has an essentially saw-tooth, trapezoidal and/or V-shaped in a cross-sectional cut through the substrate layer and the cover layer thickness is inhomogeneous.

Abstract: A diode array spectrophotometer has an entrance slit apparatus, a diffraction grating, a diode array and a casing to define the relative positions of these elements. The casing and the holder for accepting the diffraction grating are made of a ceramic whose coefficient of thermal expansion is adapted to that of the diode array. The grating holder has a cylindrical outer surface and is situated within a conic-frustum-shaped opening of the casing. Between the grating holder and the conic-frustum-shaped opening, there are a plurality of filler elements which are made of ceramic or glass.