Patents by Inventor Karsten Sauer

Karsten Sauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating T lymphocytes
    Patent number: 7595148
    Abstract: This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their activity in modulating development of progenitor T cells (e.g., CD4+/CD8+ double positive T cells) into mature CD4+ or CD8+ single positive T cells. Pharmaceutical compositions comprising these T cell modulators can be administered to a subject to modulate T cell immune responses, to suppress inflammations, and to treat disease conditions such as autoimmune diseases, graft rejection or allergies.
    Type: Grant
    Filed: January 23, 2004
    Date of Patent: September 29, 2009
    Assignee: IRM LLC
    Inventors: Michael P. Cooke, Karsten Sauer, Tim Wiltshire, Lisa Tarantino, Colin Fletcher, Ben Wen
  • Methods and compositions for modulating T lymphocytes
    Publication number: 20040265790
    Abstract: This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their activity in modulating development of progenitor T cells (e.g., CD4+/CD8+ double positive T cells) into mature CD4+ or CD8+ single positive T cells. Pharmaceutical compositions comprising these T cell modulators can be administered to a subject to modulate T cell immune responses, to suppress inflammations, and to treat disease conditions such as autoimmune diseases, graft rejection or allergies.
    Type: Application
    Filed: January 23, 2004
    Publication date: December 30, 2004
    Applicant: IRM LLC, a Delaware Limited Liability Company
    Inventors: Michael P. Cooke, Karsten Sauer, Tim Wiltshire, Lisa Tarantino, Colin Fletcher, Ben Wen