Patents by Inventor Karsten Winkler

Karsten Winkler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANSPOSASE WITH ENHANCED INSERTION SITE SELECTION PROPERTIES
    Publication number: 20220090142
    Abstract: The present invention relates to a polypeptide comprising a transposase and at least one heterologous chromatin reader element (CRE). Further, the present invention relates to a polynucleotide encoding the polypeptide. Furthermore, the present invention relates to a vector comprising the polynucleotide. In addition, the present invention relates to a kit comprising a transposase and at least one heterologous chromatin reader element (CRE).
    Type: Application
    Filed: February 13, 2019
    Publication date: March 24, 2022
    Inventors: Sven Krügener, Thomas Rose, Volker Sandig, Karsten Winkler
  • Methods for preparation of fucose-linked site specific conjugates of proteins with toxins, adjuvants, detection labels and pharmacokinetic half life extenders
    Patent number: 9765158
    Abstract: The present invention relates to eukaryotic cells for producing molecules having an atypical fucose analog on their glycomoieties and/or amino acids. It also relates to methods for producing molecules having an atypical fucose analog on their glycomoieties and/or amino acids and to molecules obtainable by said methods. It further relates to methods for producing conjugates comprising molecules having an atypical fucose analog on their glycomoieties and/or amino acids and pharmaceutical active compounds and to conjugates obtainable by said methods. In addition, the present invention relates to specific conjugates.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: September 19, 2017
    Assignee: Probiogen AG
    Inventors: Hans Henning Von Horsten, Volker Sandig, Ingo Jordan, Karsten Winkler
  • Enhancement of protein production yield mediated by a fast shuttling CDC42 GTPase
    Patent number: 9163089
    Abstract: The present invention relates to a cell for producing a secreted protein comprising a polynucleotide comprising a nucleic acid sequence encoding a fast cycling cdc42 mutant and a polynucleotide comprising a nucleic acid sequence encoding a secreted protein. It also relates to a method for producing said cell and to a method for producing a secreted protein using said cell.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: October 20, 2015
    Assignee: Probiogen AG
    Inventors: Volker Sandig, Karsten Winkler, Henning Von Horsten, Thomas Rose
  • ENHANCEMENT OF PROTEIN PRODUCTION YIELD MEDIATED BY A FAST SHUTTLING CDC42 GTPASE
    Publication number: 20140377803
    Abstract: The present invention relates to a cell for producing a secreted protein comprising a polynucleotide comprising a nucleic acid sequence encoding a fast cycling cdc42 mutant and a polynucleotide comprising a nucleic acid sequence encoding a secreted protein. It also relates to a method for producing said cell and to a method for producing a secreted protein using said cell.
    Type: Application
    Filed: May 14, 2012
    Publication date: December 25, 2014
    Applicant: PROBIOGEN AG
    Inventors: Volker Sandig, Karsten Winkler, Henning Von Horsten, Thomas Rose
  • METHODS FOR PREPARATION OF FUCOSE-LINKED SITE SPECIFIC CONJUGATES OF PROTEINS WITH TOXINS, ADJUVANTS, DETECTION LABELS AND PHARMACOKINETIC HALF LIFE EXTENDERS
    Publication number: 20140221627
    Abstract: The present invention relates to eukaryotic cells for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids. It also relates to methods for producing molecules having an atypical fucose analogue on their glycomoieties and/or amino acids and to molecules obtainable by said methods. It further relates to methods for producing conjugates comprising molecules having an atypical fucose analogue on their glycomoieties and/or amino acids and pharmaceutical active compounds and to conjugates obtainable by said methods. In addition, the present invention relates to specific conjugates.
    Type: Application
    Filed: May 31, 2012
    Publication date: August 7, 2014
    Applicant: ProBioGen AG
    Inventors: Hans Henning Von Horsten, Volker Sandig, INgo Jordan, Karsten Winkler
  • Intervention In The Energy Metabolism Of Eukaryote Cells For The Purposes Of Selection And Increased Expression
    Publication number: 20080057584
    Abstract: The invention relates to a method for expressing one or more foreign genes in eukaryote cells, wherein the energy metabolism of the cells is improved by introducing nucleic acid sequences which encode sugar carrier proteins and whose expression is linked to the expression of the foreign gene. The invention also relates to suitable transformed cells and to the use thereof. More particularly the nucleic acid sequences encode glucose carrier proteins such as GLUT-1.
    Type: Application
    Filed: April 15, 2005
    Publication date: March 6, 2008
    Inventors: Volker Sandig, Ingo Jordan, Karsten Winkler
  • High yield heterologous expression cell lines for expression of gene products with human glycosylation pattern
    Publication number: 20060148085
    Abstract: The invention relates to ubiquitous/universal processes for establishing cells capable of stable high yield expression of a recombinant gene with human glycosylation pattern, and for establishing stable universal precursor cells available for insertion of arbitrary target genes.
    Type: Application
    Filed: October 6, 2003
    Publication date: July 6, 2006
    Inventors: Volker Sandig, Karsten Winkler, Uwe Marx, Tobias Wermelinger