Abstract: The method of generating multipotent stem cells is a method for producing and/or expanding multipotent stem cells by delivering at least one reprogramming protein into somatic cells. The at least one reprogramming protein includes a Master Regulator (MR) protein, which may be BAZ2B, ZBTB20, ZMAT1, CNOT8, KLF12, DMTF1, HBP1, or FLI1. The bromodomain protein BAZ2B, in particular, was identified by first generating bi-species heterokaryons by fusing Tcf7l1?/? murine embryonic stem cells (ESCs) with human B-cell lymphocytes. Reprogramming of the B-cell nuclei to a multipotent state was tracked by human mRNA transcript profiling at multiple timepoints. Interrogation of a human B-cell regulatory network with gene expression signatures collected from such reprogramming time series identified eight candidate Master Regulator proteins, which were validated in human cord blood-derived hematopoietic progenitor and lineage-committed cells.

Abstract: Some examples relate to classifying IoT malware at a network device. An example includes receiving, by a network device, network traffic from an Internet of Things (IoT) device. Network device may analyze network parameters from the network traffic with a machine learning model. In response to analyzing, network device may classify the network traffic into a category of malware activity. Network device may determine an effectiveness of network traffic classification by measuring a deviation of the network parameters from previously trained network parameters that were used for training the machine learning model. In response to a determination that the deviation of the network parameters from the trained network parameters is more than a pre-defined threshold, network device may generate an alert highlighting the deviation, which allows a user to perform a remedial action pertaining to the IoT device.

Abstract: The invention generally features compositions and methods for detecting and regulating cell proliferation, potentiation, and differentiation in a population of cells. In particular, compositions and methods are provided for modulating the activity of Musashi proteins. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Abstract: The invention generally features compositions and methods for detecting and regulating cell proliferation, potentiation, and differentiation in a population of cells. In particular, compositions and methods are provided for modulating the activity of Musashi proteins. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.