Patents by Inventor Karthik Murali

Karthik Murali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10342698
    Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: July 9, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTE
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
  • Patent number: 9919140
    Abstract: An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: March 20, 2018
    Assignee: University of Southern California
    Inventors: Mark S. Humayun, Karthik Murali, Ramiro Magalhaes Ribeiro, Yu-chong Tai, Nicholas Scianmarello
  • Publication number: 20170348147
    Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
    Type: Application
    Filed: August 24, 2017
    Publication date: December 7, 2017
    Applicants: California Institute of Technology, University of Southern California, Doheny Eye Institute
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
  • Patent number: 9763825
    Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 19, 2017
    Assignees: California Institute of Technology, University of Southern California, Doheny Eye Institute
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
  • Patent number: 9655774
    Abstract: A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: May 23, 2017
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Nicholas Scianmarello, Dongyang Kang, Jungwook Park, Mark S. Humayun, Karthik Murali, Amir H. Kashani, Hossein Nazari Khanamiri
  • Publication number: 20170071785
    Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
    Type: Application
    Filed: September 9, 2016
    Publication date: March 16, 2017
    Applicants: California Institute of Technology, University of Southern California, Doheny Eye Institute
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
  • Publication number: 20150366707
    Abstract: A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable portions of the device have pores that are sized to be permeable to a predetermined class of small molecules, such as oxygen, nitrous oxide, or other therapeutic agents. Once absorbed inside the device, the small molecules are then passively transported, by a concentration gradient of the small molecules, to the discharge sac to be disbursed. A metal tube or other strip can be included in the cannula to assist a surgeon in orienting the device within the body.
    Type: Application
    Filed: June 19, 2015
    Publication date: December 24, 2015
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Nicholas Scianmarello, Dongyang Kang, Jungwook Park, Mark S. Humayun, Karthik Murali, Amir H. Kashani, Hossein Nazari Khanamiri
  • Publication number: 20150273197
    Abstract: An implantable oxygenator may have a configuration that is suitable for implantation within a human body be implanted within a human body, such as within a human eye. The implantable oxygenator may include an electrolyte reservoir having a configuration suitable for storing electrolyte and an electrolysis system having a configuration that performs electrolysis on a portion of the electrolyte, thereby producing oxygen in the region of the electrolysis system.
    Type: Application
    Filed: October 7, 2013
    Publication date: October 1, 2015
    Applicants: UNIVERSITY OF SOUTHERN CALIFORNIA, CALIFORNIA INSTITUTE OF TECHNOLOGY, DOHENY EYE INSTITUTE
    Inventors: Mark S. Humayun, Karthik Murali, Ramiro Magalhaes Ribeiro, Yu-chong Tai, Nicholas Scianmarello