Abstract: Antibody molecules that specifically bind to C5aR1 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

Abstract: Antibody molecule-drug conjugates (ADCs) that specifically bind to lipopolysaccharides (LPS) are disclosed. The antibody molecule-drug conjugates can be used to treat, prevent, and/or diagnose bacterial infections and related disorders.

Abstract: The present invention provides, among other things, anti-C3b antibodies with increased specificity and potency and methods of treating C3 glomerulopathy and other complement mediated diseases and disorders using the same.

Abstract: Antibody molecules that specifically bind to CD138 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as multiple myeloma.

Abstract: Antibody molecules that specifically bind to APRIL are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as IgA nephropathy.

Abstract: Antibody molecules that specifically bind to C5aR1 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

Abstract: The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof a an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

Abstract: Techniques for ensuring content output to a user conforms to a quality of the user's speech, even when a speechlet or skill ignores the speech's quality, are described. When a system receives speech, the system determines an indicator of the speech's quality (e.g., whispered, shouted, fast, slow, etc.) and persists the indicator in memory. When the system receives output content from a speechlet or skill, the system checks whether the output content is in conformity with the speech quality indicator. If the content conforms to the speech quality indicator, the system may cause the content to be output to the user without further manipulation. But, if the content does not conform to the speech quality indicator, the system may manipulate the content to render it in conformity with the speech quality indicator and output the manipulated content to the user.

Abstract: Techniques for ensuring content output to a user conforms to a quality of the user's speech, even when a speechlet or skill ignores the speech's quality, are described. When a system receives speech, the system determines an indicator of the speech's quality (e.g., whispered, shouted, fast, slow, etc.) and persists the indicator in memory. When the system receives output content from a speechlet or skill, the system checks whether the output content is in conformity with the speech quality indicator. If the content conforms to the speech quality indicator, the system may cause the content to be output to the user without further manipulation. But, if the content does not conform to the speech quality indicator, the system may manipulate the content to render it in conformity with the speech quality indicator and output the manipulated content to the user.

Abstract: Techniques for ensuring content output to a user conforms to a quality of the user's speech, even when a speechlet or skill ignores the speech's quality, are described. When a system receives speech, the system determines an indicator of the speech's quality (e.g., whispered, shouted, fast, slow, etc.) and persists the indicator in memory. When the system receives output content from a speechlet or skill, the system checks whether the output content is in conformity with the speech quality indicator. If the content conforms to the speech quality indicator, the system may cause the content to be output to the user without further manipulation. But, if the content does not conform to the speech quality indicator, the system may manipulate the content to render it in conformity with the speech quality indicator and output the manipulated content to the user.

Abstract: Techniques for ensuring content output to a user conforms to a quality of the user's speech, even when a speechlet or skill ignores the speech's quality, are described. When a system receives speech, the system determines an indicator of the speech's quality (e.g., whispered, shouted, fast, slow, etc.) and persists the indicator in memory. When the system receives output content from a speechlet or skill, the system checks whether the output content is in conformity with the speech quality indicator. If the content conforms to the speech quality indicator, the system may cause the content to be output to the user without further manipulation. But, if the content does not conform to the speech quality indicator, the system may manipulate the content to render it in conformity with the speech quality indicator and output the manipulated content to the user.

Abstract: Features are disclosed for selecting and using multiple transforms associated with a particular remote device for use in automatic speech recognition (“ASR”). Each transform may be based on statistics that have been generated from processing utterances that share some characteristic (e.g., acoustic characteristics, time frame within which the utterances where processed, etc.). When an utterance is received from the remote device, a particular transform or set of transforms may be selected for use in speech processing based on data obtained from the remote device, speech processing of a portion of the utterance, speech processing of prior utterances, etc. The transform or transforms used in processing the utterances may then be updated based on the results of the speech processing.

Abstract: Speech recognition may be improved using data derived from an utterance. In some embodiments, audio data is received by a user device. Adaptation data may be retrieved from a data store accessible by the user device. The audio data and the adaptation data may be transmitted to a server device. The server device may use the audio data to calculate second adaptation data. The second adaptation data may be transmitted to the user device. Synchronously or asynchronously, the server device may perform speech recognition using the audio data and the second adaptation data and transmit speech recognition results back to the user device.

Abstract: In automatic speech recognition, certain parsing information, such as rules and tags, may be embedded into a finite state transducer (FST) to produce FST output that includes speech recognition results along with codes indicating parsing results of the recognized speech. The codes in the FST output may be formatted using a markup language, such as XML or JSON, for processing by a later application. The FST may be constructed according to a grammar defining the parsing information. The codes for inclusion in the FST output may be embedded into arcs of the FST and then included in the FST output when the speech recognition engine traverses the arcs of the FST.

Abstract: A system and method for active profile services is provided. An embodiment includes an active profile server that is configured to respond to requests for subscriber profile information from an application server. The profile server is further configured to access a known set of profile information for a subscriber and, according to predefined criteria, automatically modify the known set of subscriber profile information and provide the modified profile information to the application server.

Abstract: A method for Internet Protocol (IP) charging and rating gateway within a system having: a proxy server for connection to an Authentication, Authorization, and Accounting (AAA) server; an access gateway, an IP classification engine for connection between a data network and the access gateway; and a gateway controller connected to the proxy server and the IP classification engine, including the steps of: receiving IP packets at the IP classification engine, the IP packets originating from the data network and destined for a subscriber device via the access gateway; classifying the IP packets according to the protocol of each of the packets at the IP classification engine; and selectively instructing the IP classification engine to permit or deny the flow of IP packets between the data network and the access gateway at the gateway controller. Preferably, the proxy server is configured to emulate the access gateway and the AAA server.

Abstract: Disclosed is a species of control-message intercept method which includes a passive monitoring approach whereby the relevant control packets are inspected for the purpose of providing additional information for the purpose of facilitating the operation of some primary or ‘master’ Internet Protocol (IP) charging/rating middleware platform/ gateway system (intended to equip network operators with the ability to rate and bill IP traffic), and secondly, an invasive technique whereby control (GTP-C) messages are injected for the purpose of altering the state of a given data session in an more aggressive fashion (e.g. to drop a data session when the subscriber runs out of money in his/her prepaid account).

Abstract: Disclosed is a species of control-message intercept method which includes a passive monitoring approach whereby the relevant control packets are inspected for the purpose of providing additional information for the purpose of facilitating the operation of some primary or ‘master’ Internet Protocol (IP) charging/rating middleware platform/gateway system (intended to equip network operators with the ability to rate and bill IP traffic), and secondly, an invasive technique whereby control (GTP-C) messages are injected for the purpose of altering the state of a given data session in an more aggressive fashion (e.g. to drop a data session when the subscriber runs out of money in his/her prepaid account).

Abstract: A method for Internet Protocol (IP) charging and rating gateway within a system having: (i) a proxy server for connection to an Authentication, Authorization, and Accounting (AAA) server; (ii) an access gateway, (iii) an IP classification engine for connection between a data network and the access gateway; and (iv) a gateway controller connected to the proxy server and the IP classification engine, including the steps of: (a) receiving IP packets at the IP classification engine, the IP packets originating from the data network and destined for a subscriber device via the access gateway; (b) classifying the IP packets according to the protocol of each of the packets at the IP classification engine; and (c) selectively instructing the IP classification engine to permit or deny the flow of IP packets between the data network and the access gateway at the gateway controller. Preferably, the proxy server is configured to emulate the access gateway and the AAA server.

Abstract: The method for implementing an Intelligent Content Rating middleware platform and gateway system disclosed herewith provides telecommunications carriers and network operators with the ability to define routing and actions based on HTIP/SIP based content and subscriber context through a powerful, extensible Layer 4-7 switching fabric technology. The invention mediates communications between applications and networks for IP packet flows, personal messaging, location-based services and billing. Furthermore, it enables advanced context-sensitive dialogue scenarios with the wireless subscriber such as, but not limited to, Advice-of-Charge dialogues. The art permits telecommunications network operators and like entities to introduce real-time rating of data services for both prepaid and post-paid subscribers. Further advances in the art include the validation of digital signatures, combined with authentication and non-repudiation techniques to ensure subscriber privacy remains protected.