Patents by Inventor Kary B. Mullis
Kary B. Mullis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8604184Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound are provided. The present invention is directed to an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target. The second binding sites are preferably thiolated aptamers that have the benefit of increased stability, resistance to degradation and longer circulating half life. Methods of making and using pharmaceutical compositions including immunity linker molecules having a thiolated aptamer are also provided.Type: GrantFiled: May 5, 2010Date of Patent: December 10, 2013Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Kary B. Mullis, Jeevalatha Vivekananda, Johnathan Lloyd Kiel, Ronald M. Cook
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Patent number: 8591910Abstract: The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an immunity linker molecule with at least two sites; (1) a first binding site that binds to an immune system molecule in a human or animal that has been preimmunized against the first binding site, and (2) one or more second binding sites that bind specifically to a desired compound or molecule. The first binding site and the second binding site(s) are linked by a linker portion of the molecule.Type: GrantFiled: July 6, 2012Date of Patent: November 26, 2013Assignee: Altermune Technologies LLCInventor: Kary B. Mullis
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Publication number: 20120301466Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual that has been pre-immunized with a universal immunogen, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target.Type: ApplicationFiled: August 6, 2012Publication date: November 29, 2012Applicant: ALTERMUNE TECHNOLOGIES LLCInventor: Kary B. MULLIS
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Publication number: 20120276136Abstract: The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an immunity linker molecule with at least two sites; (1) a first binding site that binds to an immune system molecule in a human or animal that has been preimmunized against the first binding site, and (2) one or more second binding sites that bind specifically to a desired compound or molecule. The first binding site and the second binding site(s) are linked by a linker portion of the molecule.Type: ApplicationFiled: July 6, 2012Publication date: November 1, 2012Applicant: ALTERMUNE TECHNOLOGIES, LLCInventor: Kary B. Mullis
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Patent number: 8236321Abstract: The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an immunity linker molecule with at least two sites; (1) a first binding site that binds to an immune system molecule in a human or animal that has been preimmunized against the first binding site, and (2) one or more second binding sites that bind specifically to a desired compound or molecule. The first binding site and the second binding site(s) are linked by a linker portion of the molecule.Type: GrantFiled: December 17, 2008Date of Patent: August 7, 2012Assignee: Altermune Technologies, LLCInventor: Kary B. Mullis
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Patent number: 7850975Abstract: The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an immunity linker molecule with at least two sites; (1) a first binding site that binds to an immune system molecule in a human or animal that has been preimmunized against the first binding site, and (2) one or more second binding sites that bind specifically to a desired compound or molecule. The first binding site and the second binding site(s) are linked by a linker portion of the molecule.Type: GrantFiled: November 30, 2006Date of Patent: December 14, 2010Assignee: Altermune Technologies, LLCInventor: Kary B. Mullis
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Publication number: 20100285052Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound are provided. The present invention is directed to an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target. The second binding sites are preferably thiolated aptamers that have the benefit of increased stability, resistance to degradation and longer circulating half life. Methods of making and using pharmaceutical compositions including immunity linker molecules having a thiolated aptamer are also provided.Type: ApplicationFiled: May 5, 2010Publication date: November 11, 2010Inventors: KARY B. MULLIS, JEEVALATHA VIVEKANANDA, JOHNATHAN LLOYD KIEL, RONALD M. COOK
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Publication number: 20100247535Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual that has been pre-immunized with a universal immunogen, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target.Type: ApplicationFiled: January 11, 2010Publication date: September 30, 2010Applicant: Altermune LLCInventor: Kary B. Mullis
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Patent number: 7645743Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual that has been pre-immunized with a universal immunogen, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target.Type: GrantFiled: January 9, 2004Date of Patent: January 12, 2010Assignee: Altermune, LLCInventor: Kary B. Mullis
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Publication number: 20090142368Abstract: The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an immunity linker molecule with at least two sites; (1) a first binding site that binds to an immune system molecule in a human or animal that has been preimmunized against the first binding site, and (2) one or more second binding sites that bind specifically to a desired compound or molecule. The first binding site and the second binding site(s) are linked by a linker portion of the molecule.Type: ApplicationFiled: December 17, 2008Publication date: June 4, 2009Inventor: Kary B. Mullis
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Patent number: 7422746Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual that has been pre-immunized with a universal immunogen, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target.Type: GrantFiled: October 29, 2003Date of Patent: September 9, 2008Assignee: Altermune, LLCInventor: Kary B. Mullis
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Publication number: 20040185054Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual that has been pre-immunized with a universal immunogen, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target.Type: ApplicationFiled: January 9, 2004Publication date: September 23, 2004Inventor: Kary B. Mullis
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Publication number: 20040146515Abstract: Methods and compositions for immediately immunizing an individual against any molecule or compound. The present invention comprises an immunity linker with at least two sites; (1) at least one first binding site that binds to an immune response component in an individual that has been pre-immunized with a universal immunogen, and (2) at least one second binding site that binds specifically to a desired compound or molecule, the target.Type: ApplicationFiled: October 29, 2003Publication date: July 29, 2004Inventor: Kary B. Mullis
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Patent number: 6514736Abstract: The present invention is directed to a process for amplifying any target nucleic acid sequence contained in a nucleic acid or mixture thereof using a thermostable enzyme. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, extending the primers with a thermostable enzyme to form complementary primer extension products which act as templates for synthesizing the desired nucleic acid sequence, and detecting the sequence so amplified. The steps of the reaction can be repeated as often as desired and involve temperature cycling to effect hybridization, promotion of activity of the enzyme, and denaturation of the hybrids formed.Type: GrantFiled: November 1, 2000Date of Patent: February 4, 2003Assignee: Roche Molecular Systems, IncInventors: Henry A. Erlich, Glenn Horn, Randall K. Saiki, Kary B. Mullis, David H. Gelfand
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Publication number: 20030017165Abstract: The present invention is related to methods and compositions that are capable of immediately immunizing a human or animal against any molecule or compound. The present invention comprises an immunity linker molecule with at least two sites; (1) a first binding site that binds to an immune system molecule in a human or animal that has been preimmunized against the first binding site, and (2) one or more second binding sites that bind specifically to a desired compound or molecule. The first binding site and the second binding site(s) are linked by a linker portion of the molecule.Type: ApplicationFiled: June 21, 2002Publication date: January 23, 2003Inventor: Kary B. Mullis
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Patent number: 6197563Abstract: The present invention is directed to a process for amplifying any target nucleic acid sequence contained in a nucleic acid or mixture thereof using a thermostable enzyme. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, extending the primers with a thermostable enzyme to form complementary primer extension products which act as templates for synthesizing the desired nucleic acid sequence, and detecting the sequence so amplified. The steps of the reaction can be repeated as often as desired and involve temperature cycling to effect hybridization, promotion of activity of the enzyme, and denaturation of the hybrids formed.Type: GrantFiled: November 18, 1994Date of Patent: March 6, 2001Assignee: Roche Molecular Systems, Inc.Inventors: Henry A. Erlich, Glenn Horn, Randall K. Saiki, Kary B. Mullis, David H. Gelfand
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Patent number: 6040166Abstract: The present invention is directed to a process for amplifying any target nucleic acid sequence contained in a nucleic acid or mixture thereof using a thermostable enzyme. The process comprises treating separate complementary strands of the nucleic acid with a molar excess of two oligonucleotide primers, extending the primers with a thermostable enzyme to form complementary primer extension products which act as templates for synthesizing the desired nucleic acid sequence, and detecting the sequence so amplified. The steps of the reaction can be repeated as often as desired and involve temperature cycling to effect hybridization, promotion of activity of the enzyme, and denaturation of the hybrids formed.Type: GrantFiled: September 27, 1994Date of Patent: March 21, 2000Assignee: Roche Molecular Systems, Inc.Inventors: Henry A. Erlich, Glenn Horn, Randall K. Saiki, Kary B. Mullis, David H. Gelfand
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Patent number: 5656493Abstract: There is disclosed herein a machine for performing nucleic acid amplification under computer control. The machine utilizes any one of a number of heating and cooling systems under control of a host computer which directs the heating and cooling systems to heat and cool a reaction-chamber-containing heat exchanger at appropriate times in the process. The reaction chambers are pre-loaded with the nucleic acid(s) to be amplified, a thermostable enzyme to catalyze polymerization, specific oligonucleotide primers, and four different nucleotide triphosphates. Also disclosed is the process for the amplification chain reaction implemented by the machine, which utilizes a thermostable enzyme.Type: GrantFiled: February 18, 1994Date of Patent: August 12, 1997Assignee: The Perkin-Elmer CorporationInventors: Kary B. Mullis, Larry Johnson, Richard A. Leath, Timothy J. Wennberg, Louis M. Mezei, Joseph T. Widunas
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Patent number: 5604099Abstract: Single or multiple nucleotide variations in nucleic acid sequence can be detected in nucleic acids by a process whereby the sample suspected of containing the relevant nucleic acid is repeatedly treated with primers, nucleotide triphosphates, and an agent for polymerization of the triphosphates and then denatured, in a process which amplifies the sequence containing the nucleotide variation if it is present. In one embodiment, the sample is spotted on a membrane and treated with a labeled sequence-specific oligonucleotide probe. Hybridization of the probe to the sample is detected by the label on the probe.Type: GrantFiled: June 1, 1995Date of Patent: February 18, 1997Assignee: Hoffmann-La Roche Inc.Inventors: Henry A. Erlich, Glenn Horn, Randall K. Saiki, Kary B. Mullis
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Patent number: 5468613Abstract: Single or multiple nucleotide variations in nucleic acid sequence can be detected in nucleic acids by a process whereby the sample suspected of containing the relevant nucleic acid is repeatedly treated with primers, nucleotide triphosphates, and an agent for polymerization of the triphosphates and then denatured, in a process which amplifies the sequence containing the nucleotide variation if it is present. In one embodiment, the sample is spotted on a membrane and treated with a labeled sequence-specific oligonucleotide probe. Hybridization of the probe to the sample is detected by the label on the probe.Type: GrantFiled: March 9, 1990Date of Patent: November 21, 1995Assignee: Hoffmann-La Roche Inc.Inventors: Henry A. Erlich, Glenn Horn, Randall K. Saiki, Kary B. Mullis