Patents by Inventor Karyn L. Cepek

Karyn L. Cepek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes
    Patent number: 7029676
    Abstract: The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: April 18, 2006
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Karyn L. Cepek
  • Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes
    Publication number: 20020192724
    Abstract: The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
    Type: Application
    Filed: June 7, 2002
    Publication date: December 19, 2002
    Inventors: Michael B. Brenner, Karyn L. Cepek
  • Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes
    Patent number: 6406870
    Abstract: The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: June 18, 2002
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Karyn L. Cepek
  • Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes
    Patent number: 6300080
    Abstract: The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: October 9, 2001
    Assignee: Brigham and Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Karyn L. Cepek
  • Methods and compositions for modulating heterotypic E-cadherin interactions with T lymphocytes
    Publication number: 20010018189
    Abstract: The present invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
    Type: Application
    Filed: March 2, 2001
    Publication date: August 30, 2001
    Inventors: Michael B. Brenner, Karyn L. Cepek
  • Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes
    Patent number: 5610281
    Abstract: The invention relates to methods and compositions for modulating the heterotypic adhesion between E-cadherin expressing cells and T lymphocytes. Monoclonal antibodies which specifically bind to E-cadherin and isolated peptides which mimic the binding function of E-cadherin also are provided. The antibodies and peptides are useful in screening assays to identify pharmaceutical lead compounds which are capable of modulating adhesion between T lymphocytes and E-cadherin expressing cells. Methods and pharmaceutical compositions for modifying the mucosal immune response of a subject also are provided.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: March 11, 1997
    Assignee: Brigham & Women's Hospital, Inc.
    Inventors: Michael B. Brenner, Karyn L. Cepek