Patents by Inventor Karyn O'Neil

Karyn O'Neil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-GLP-1R Antibodies and Their Uses
    Publication number: 20110098443
    Abstract: The present invention relates to antibodies reactive with GLP-1R, and methods of making and using them.
    Type: Application
    Filed: October 27, 2010
    Publication date: April 28, 2011
    Inventors: Karyn O'Neil, Kristen Picha
  • Melanocortin receptor binding mimetibodies, compositions, methods and uses
    Patent number: 7910101
    Abstract: Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: March 22, 2011
    Assignee: Centocor, Inc.
    Inventors: Mark Cunningham, Vedrana Stojanovic-Susulic, Karyn O'Neil, Chichi Huang, Jeffrey Luo
  • GLP-2 mimetibodies, polypeptides, compositions, methods and uses
    Patent number: 7812121
    Abstract: Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: October 12, 2010
    Inventors: Audrey E. Baker, Beverly A. Moore, Thomas Nesspor, Karyn O'Neil, Jeffrey M. Palmer, Kristen Picha, Sarah Sague
  • Fibronectin Type III Domain Based Scaffold Compositions, Methods And Uses
    Publication number: 20100255056
    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.
    Type: Application
    Filed: February 12, 2010
    Publication date: October 7, 2010
    Inventors: Steven Jacobs, Karyn O'Neil
  • ENGINEERED HYBIRD PHAGE VECTORS FOR THE DESIGN AND THE GENERATION OF A HUMAN NON-ANTIBODY PEPTIDE OR PROTEIN PHAGE LIBRARY VIA FUSION TO pIX OF M13 PHAGE
    Publication number: 20100249377
    Abstract: The invention relates to a compositions and methods for generating and using pIX phage display libraries for producing non-antibody peptide or protein proteins or peptides using engineered hybrid phage vectors derived from pIX of M 13 phage
    Type: Application
    Filed: November 21, 2008
    Publication date: September 30, 2010
    Inventors: Bryan Wang, Karyn O'Neil
  • Solution phase biopanning method using engineered decoy proteins
    Patent number: 7790405
    Abstract: The invention relates to a method of directing selection of biological therapeutic molecules to specific functional domains of the target biologic molecule. Selection is directed by the use of closely related molecules, where one is a decoy and the other contains the targeted domain or epitope. The invention is based on the use of physical data, which may be combined with derived data, to ascertain that the decoy and the target differ only in the specific functional domain or epitope where the binding will be directed.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: September 7, 2010
    Assignee: Centocor, Inc.
    Inventors: Karyn O'Neil, Raymond Sweet, George Heavner
  • Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    Publication number: 20100216708
    Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
    Type: Application
    Filed: October 27, 2009
    Publication date: August 26, 2010
    Inventors: Steven Jacobs, Karyn O'Neil
  • Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses
    Publication number: 20100144601
    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNF? including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
    Type: Application
    Filed: October 27, 2009
    Publication date: June 10, 2010
    Inventors: Steven Jacobs, Karyn O'Neil
  • CYNOMOLGUS IL-13 MUTEIN PROTEINS, ANTIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20100129318
    Abstract: The present invention relates to at least one novel cynomolgus IL-13 muteins (Mut-IL-13) proteins, antibodies, including isolated nucleic acids that encode at least one Mut-IL-13 protein or antibody, Mut-IL-13 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: October 12, 2007
    Publication date: May 27, 2010
    Applicant: CENTOCOR ORTHO BIOTECH INC.
    Inventors: Karyn O'Neil, Leslee Conrad, Dusti Fisher
  • Melanocortin Receptor Binding Mimetibodies, Compositions, Methods and Uses
    Publication number: 20090186020
    Abstract: Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 23, 2009
    Inventors: Mark Cunningham, Vedrana Stojanovic-Susulic, Karyn O'Neil, Chichi Huang, Jeffrey Luo
  • GLP-2 Mimetibodies, Polypeptides, Compositions, Methods and Uses
    Publication number: 20090117104
    Abstract: Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed.
    Type: Application
    Filed: August 31, 2007
    Publication date: May 7, 2009
    Inventors: Audrey E. Baker, Beverly A. Moore, Thomas Nesspor, Karyn O'Neil, Jeffrey M. Palmer, Kristen Picha, Sarah Sague
  • Epitope directed selection of antibodies to murine tissue factor
    Patent number: 7514539
    Abstract: A tissue factor antibody which binds to non-human tissue factor and is useful as a surrogate in preclinical testing where the human therapeutic tissue factor candidate antibody does not interact with the homolog target protein in a manner that would provide meaningful information about treatment efficacy or safety.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: April 7, 2009
    Assignee: Centocor, Inc.
    Inventors: Karyn O'Neil, Raymond Sweet
  • Anti-IL-13 antibodies, compositions, methods and uses
    Publication number: 20080044420
    Abstract: The present invention relates to at least one novel anti-IL-13 antibody, including isolated nucleic acids that encode at least one anti-IL-13 antibody, IL-13, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: May 10, 2006
    Publication date: February 21, 2008
    Inventors: George Heavner, Li Li, Michael Naso, Karyn O'Neil, Robert Rauchenberger, Raymond Sweet
  • HUMAN GLP-1 MIMETIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20080044411
    Abstract: The present invention relates to at least one improved human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: July 18, 2007
    Publication date: February 21, 2008
    Inventors: Karyn O'NEIL, Kristen Picha
  • GLP-2 Mimetibodies, Polypeptides, Compositions, Methods and Uses
    Publication number: 20070212355
    Abstract: Mammalian GLP-2 mimetibodies, polypeptides and nucleic acids are disclosed. Methods of utilizing the mimetibodies and polypeptides to treat GLP-2 related diseases are also disclosed.
    Type: Application
    Filed: October 24, 2006
    Publication date: September 13, 2007
    Inventors: Audrey Baker, Beverly Moore, Thomas Nesspor, Karyn O'Neil, Jeffrey Palmer, Kristen Picha, Sarah Sague
  • Human GLP-1 mimetibodies, compositions, methods and uses
    Publication number: 20070135338
    Abstract: The present invention relates to at least one novel human GLP-1 mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or specified portion or variant, GLP-1 mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
    Type: Application
    Filed: March 28, 2005
    Publication date: June 14, 2007
    Inventors: Karyn O'Neil, Kristen Picha
  • GLP-1 agonists, compositions, methods and uses
    Publication number: 20070128193
    Abstract: The present invention relates to at least one novel human GLP-1 mimetibody or agonist, or specified portion or variant, including isolated nucleic acids that encode at least one GLP-1 mimetibody or agonist, or specified portion or variant, GLP-1 mimetibody or agonist, or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including diabetes related therapeutic and/or diagnositic compositions, methods and devices.
    Type: Application
    Filed: December 22, 2005
    Publication date: June 7, 2007
    Inventors: Karyn O'Neil, Kristen Picha, John O'Neil, Gang Xu, Michael Lark
  • Melanocortin receptor binding mimetibodies, compositions, methods and uses
    Publication number: 20060105951
    Abstract: Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed.
    Type: Application
    Filed: October 25, 2005
    Publication date: May 18, 2006
    Inventors: Mark Cunningham, Vedrana Stojanovic-Susulic, Karyn O'Neil, Chichi Huang, Jeffrey Luo
  • Epitope directed selection of antibodies to murine tissue factor
    Publication number: 20060039900
    Abstract: A tissue factor antibody which binds to non-human tissue factor and is useful as a surrogate in preclinical testing where the human therapeutic tissue factor candidate antibody does not interact with the homolog target protein in a manner that would provide meaningful information about treatment efficacy or safety.
    Type: Application
    Filed: April 22, 2005
    Publication date: February 23, 2006
    Inventors: Karyn O'Neil, Raymond Sweet
  • Methods and compositions for treating IL-3 related pathologies
    Publication number: 20050266005
    Abstract: The present invention relates to compositions and methods for treating at least one IL-13 related condition or pathology, including therapeutic compositions, formulations, methods and devices.
    Type: Application
    Filed: February 18, 2005
    Publication date: December 1, 2005
    Inventors: George Heavner, Li Li, Karyn O'Neil