Patents by Inventor Kashan Shaikh
Kashan Shaikh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132826Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.Type: ApplicationFiled: December 29, 2023Publication date: April 25, 2024Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11932842Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.Type: GrantFiled: February 8, 2019Date of Patent: March 19, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11920119Abstract: A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.Type: GrantFiled: February 8, 2019Date of Patent: March 5, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11541356Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.Type: GrantFiled: October 3, 2018Date of Patent: January 3, 2023Assignee: Global Life Sciences Solutions USA LLCInventors: Chengkun Zhang, Kashan A. Shaikh, Weston B. Griffin, Reginald Donovan Smith
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Patent number: 11414639Abstract: A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.Type: GrantFiled: February 8, 2019Date of Patent: August 16, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20220251496Abstract: A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.Type: ApplicationFiled: May 2, 2022Publication date: August 11, 2022Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D. Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11371007Abstract: A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.Type: GrantFiled: February 8, 2019Date of Patent: June 28, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20210102156Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.Type: ApplicationFiled: February 8, 2019Publication date: April 8, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20210102153Abstract: In an embodiment, a tubing module for a bioprocessing system includes a first tubing holder block configured to receive at least one pump tube and hold the at least one pump tube in position for selective engagement with a peristaltic pump, a second tubing holder block configured to receive a plurality of pinch valve tubes and hold each pinch valve tube of the plurality of pinch valve tubes in position for selective engagement with a respective actuator of a pinch valve array, and wherein the first tubing holder block and the second tubing holder block are interconnected.Type: ApplicationFiled: February 8, 2019Publication date: April 8, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20210102157Abstract: A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.Type: ApplicationFiled: February 8, 2019Publication date: April 8, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20210087511Abstract: A bioprocessing method for cell therapy includes the steps of genetically modifying a population of cells in a bioreactor vessel to produce a population of genetically modified cells, and expanding the population of genetically modified cells within the bioreactor vessel to generate a number of genetically modified cells sufficient for one or more doses for use in a cell therapy treatment without removing the population of genetically modified cells from the bioreactor vessel. Cells are settled on a gas permeable, liquid impermeable membrane for expansion, and are resuspended when, or after, the desired cell density is reached.Type: ApplicationFiled: February 8, 2019Publication date: March 25, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20210087510Abstract: A system for bioprocessing includes a tray having plurality of sidewalls and a bottom surface defining an interior compartment, and a generally open top, and an opening formed in the bottom surface of the tray, the opening having a perimeter. The perimeter of the opening is shaped and/or dimensioned such that a bioreactor vessel can be positioned above the opening and supported by the bottom surface of the tray while a portion of the bioreactor vessel is accessible through the opening in the bottom surface. The tray is receivable within a processing chamber such that the bed plate extends through the opening in the bottom surface of the tray to support the bioreactor vessel.Type: ApplicationFiled: February 8, 2019Publication date: March 25, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20210002599Abstract: A non-transitory computer readable medium includes instructions configured to adapt a controller to maintain a first target environment in a bioreactor vessel containing a population of cells for a first incubation period to produce a population of genetically modified cells from the population of cells, initiate a flow of media to the bioreactor vessel, maintain a second target environment in the bioreactor vessel for a second incubation period to produce an expanded population of genetically modified cells.Type: ApplicationFiled: February 8, 2019Publication date: January 7, 2021Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20200392446Abstract: A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.Type: ApplicationFiled: February 8, 2019Publication date: December 17, 2020Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20200392449Abstract: A bioprocessing system includes a first fluid assembly having a first fluid assembly line connected to a first port of a first bioreactor vessel though a first bioreactor line of a first bioreactor vessel, a second fluid assembly having a second fluid assembly line connected to a second port of the first bioreactor vessel through a second bioreactor line of the first bioreactor vessel, and an interconnect line providing for fluid communication between the first fluid assembly and the second fluid assembly, and for fluid communication between the second bioreactor line of the first bioreactor vessel and the first bioreactor line of the first bioreactor vessel.Type: ApplicationFiled: February 8, 2019Publication date: December 17, 2020Applicant: Global Life Sciences Solutions USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Publication number: 20200231921Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.Type: ApplicationFiled: October 3, 2018Publication date: July 23, 2020Inventors: Chengkun Zhang, Kashan A. Shaikh, Weston B. Griffin, Reginald Donovan Smith
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Patent number: 7351303Abstract: Microfluidic systems and components. A microfluidic system includes one or more functional units or microfluidic chips, configured to perform constituent steps in a process and interconnected to form the system. A multi-layer microfluidic system includes a separate dedicated fluid layer and dedicated electromechanical layer connected via through-holes. Electromechanical components are formed on the electromechanical layer.Type: GrantFiled: October 9, 2003Date of Patent: April 1, 2008Assignee: The Board of Trustees of the University of IllinoisInventors: Chang Liu, Kashan Shaikh, Kee Ryu, Edgar Goluch, Zhifang Fan, David Bullen
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Publication number: 20080017306Abstract: Microfluidic systems and components. A microfluidic system includes one or more functional units or microfluidic chips, configured to perform constituent steps in a process and interconnected to form the system. A multi-layer microfluidic system includes a separate dedicated fluid layer and dedicated electromechanical layer connected via through-holes. Electromechanical components are formed on the electromechanical layer.Type: ApplicationFiled: October 9, 2003Publication date: January 24, 2008Inventors: Chang Liu, Kashan Shaikh, Kee Ryu, Edgar Goluch, Zhifang Fan, David Bullen