Abstract: A multi-sense system adapted for prevention of occupational diseases in a working environment includes a protective facial mask adapted for application in the front zone of a person's face, having nose and mouth areas, and including: —a temperature and humidity sensor adapted to be activated when the mask is worn, and adapted to provide time-related data concerning the activation as well as temperature and humidity values; —removable air filter elements applied to the front side parts of the mask; —inhalation and exhalation valves applied to the front zone of the mask, in front of the mouth, when the mask is worn; —elements for securing the mask to the face; —an electronic nose device adapted to provide, when worn by the person, time-related data about the quality of the air in the working environment; —a breathing detection device, adapted to provide, when worn by the person, time-related data about the respiratory rate; —a data processing and displaying device, adapted to receive and store the data outputte