Abstract: An exchangeable separation insert and a modular centrifugal separator are disclosed. The insert includes a rotatable rotor casing and a first stationary portion. The rotor casing delimits a separation space and includes frustoconical separation discs. The first stationary portion is biased in a first direction away from the rotor casing along an axial direction.

Abstract: A centrifugal separator bowl includes a rotor casing enclosing a separation space in which a stack of frustoconical separation discs is arranged to rotate around a vertical axis of rotation, wherein the separation discs are arranged with the imaginary apex pointing to the axially lower end of the rotor casing; a feed inlet at the axially lower end for receiving the fluid mixture to be separated; a distributor for distributing the fluid mixture from the inlet to the separation space, the distributor being arranged for guiding the fluid mixture to be separated continuously from an axially lower position at the inlet to an axially upper position in the separation space.

Abstract: An exchangeable separation insert for a centrifugal separator includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged, and first and second stationary portions. A feed inlet supplies a fluid mixture to the separation space. The insert includes a light phase outlet and a heavy phase outlet. The feed inlet is arranged at a first axial end of the rotor casing. One of the light phase outlet and heavy phase outlet is arranged at a second axial end. A first rotatable seal seals and connects the feed inlet and a second rotatable seal seals and connects one of the light phase outlet and heavy phase outlet.

Abstract: A centrifugal separator bowl includes a rotor casing enclosing a separation space in which a stack of frustoconical separation discs is arranged to rotate around a vertical axis of rotation, wherein the separation discs are arranged with the imaginary apex pointing to the axially lower end of the rotor casing; a feed inlet at the axially lower end for receiving the fluid mixture to be separated; a distributor for distributing the fluid mixture from the inlet to the separation space, the distributor being arranged for guiding the fluid mixture to be separated continuously from an axially lower position at the inlet to an axially upper position in the separation space.

Abstract: An exchangeable separation insert for a centrifugal separator includes a feed inlet, a light phase outlet and a heavy phase outlet. Two of the feed inlet, light phase outlet and heavy phase outlet are arranged at a first axial end of the rotor casing. A first seal assembly seals and connects the two inlet/outlets to a corresponding inlet conduit and/or outlet conduits in the first stationary portion. The first seal assembly includes a rotatable part and a stationary part. The rotatable and stationary part are axially aligned and seal against each other. A first of the two inlet/outlets is arranged axially at the axis of rotation and a second of the two inlet/outlets is arranged axially outside of the first of the two inlet/outlets in such a manner that both the first and second of the two inlet/outlets are led through the rotatable part and the corresponding inlet conduit and/or outlet conduits are led through the stationary part of the first seal assembly.

Abstract: A centrifugal separation system includes a centrifugal separator, a liquid feed mixture conduit, a light phase conduit, a heavy phase conduit, and a flow control system. The flow control system includes a controller, a counterpressure generating arrangement connected to a heavy phase conduit, a liquid feed mixture measuring device, and a light phase measuring device and/or a heavy phase measuring device. The counterpressure generating arrangement includes a heavy phase receiving vessel and a heavy phase pressure control arrangement connected to the vessel. The controller is configured to control the heavy phase pressure control arrangement based on measurements from the liquid feed mixture measuring device and on measurements from the light phase measuring device and/or the heavy phase measuring device in order to control a heavy phase counterpressure in the heavy phase outlet passage.

Abstract: An exchangeable separation insert, a modular centrifugal separator, and a method are disclosed. The exchangeable separation insert includes a rotor casing rotatable about an axis of rotation and a first stationary portion. The exchangeable separation insert includes a ring member which extends concentrically with the axis. The ring member is axially displaceable between a first position, in which the ring member abuts radially against the rotor casing and abuts radially, against the first stationary portion, and a second position, in which the ring member abuts radially against the rotor casing only, or against the first stationary portion only.

Abstract: A base unit and a modular centrifugal separator are disclosed. The base unit includes a stationary frame, a rotatable member, and a drive unit. The rotatable member delimits an inner space being configured for receiving at least one part of an exchangeable separation insert therein. The rotatable member is provided with a first opening at a first axial end configured for a first fluid connection of the exchangeable separation insert to extend through the first opening. The rotatable member includes a second opening at a second axial end configured for a second fluid connection of the exchangeable separation insert to extend through the second opening.

Abstract: A centrifugal separation system includes a centrifugal separator, a liquid feed mixture conduit, a light phase conduit, a heavy phase conduit, and a flow control system. The flow control system includes a controller, a flow control valve arranged in a light phase conduit, a liquid feed mixture measuring device, and at a light phase measuring device and/or a heavy phase measuring device. The controller is configured to control the flow control valve based on measurements from the liquid feed mixture measuring device and measurements from the light phase measuring device and/or the heavy phase measuring device.

Abstract: A centrifugal separator for separation of a cell culture mixture includes a stationary frame, a rotatable assembly and a drive unit for rotating the rotatable assembly relative the frame around a vertical axis of rotation. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around an axis of rotation. The rotor casing includes a mechanically hermetically sealed inlet and first and second mechanically hermetically sealed liquid outlets. The second mechanically hermetically sealed outlet is arranged at an axial end of the rotor casing opposite and arranged so that a separated cell phase is discharged at the rotational axis. The rotatable assembly includes an exchangeable separation insert and a rotatable member.

Abstract: A method for separating a cell culture mixture utilizes a centrifugal separator including a stationary frame, a rotatable assembly and a drive unit for rotating the rotatable assembly relative the frame around a vertical axis of rotation. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around an axis of rotation. The rotor casing includes a mechanically hermetically sealed inlet for supply of the cell culture mixture to the separation space and first and second mechanically hermetically sealed liquid outlets. The second mechanically hermetically sealed outlet is arranged at an axial end of the rotor casing and arranged so that the separated cell phase is discharged at the rotational axis.

Abstract: An exchangeable separation insert and a modular centrifugal separator are disclosed. The insert includes a rotatable rotor casing and a first stationary portion. The rotor casing delimits a separation space and includes frustoconical separation discs. The first stationary portion is biased in a first direction away from the rotor casing along an axial direction.

Abstract: A centrifugal separator includes a frame and a drive member configured to rotate a rotating part in relation to the frame around an axis of rotation. The rotating part includes a centrifuge rotor enclosing a separation space. The centrifuge rotor is adjoined to a hollow spindle supported by the frame by at least one bearing device. The interior of the hollow spindle is in thermal contact with the at least one bearing device and further includes a thermal transfer medium inlet for supplying a thermal transfer medium to said interior and a thermal transfer medium outlet for withdrawing the thermal transfer medium from the interior; and directing mechanism for directing thermal transfer medium from the thermal transfer medium inlet to the thermal transfer medium outlet in a first direction along the length of the spindle and in a second direction along the length of the spindle. The second direction is opposite the first direction.

Abstract: A gasket locating arrangement for a flow module, preferably plate reactor, includes a gasket, one or more locating devices, a channel in a channel plate, and a barrier plate. The gasket consists of a sheet of soft gasket material. The sheet has a cut through pattern corresponding to the channel in the channel plate. The locating devices are in the gasket, in the channel plate, in the barrier plate or combinations thereof. The locating devices are headed pins, fitting pins, protruded pins, integrated pins, dowel pins, grooves, holes, under cut recesses, thickened parts in the gasket material, and/or gasket deformation zones.

Abstract: The present invention relates to a gasket locating arrangement for a flow module, preferably plate reactor, comprising a gasket, locating means, a channel in a channel plate, a barrier plate, wherein the gasket consists of a sheet of soft gasket material, and said sheet has a cut through pattern corresponding to the channel in the channel plate. The present invention relates further to a use of the gasket location arrangement and also to a flow module, preferably a plate reactor, which comprises one or more gasket locating arrangements according to the invention, and one or more heat transfer means for heat transfer to and from the channel, and wherein each channel plate has one or more inlets, preferably two inlets, to the channel, and one outlet from the channel.

Abstract: A flow-plate is dividable in mid plane. The flow-plate includes two parts, each part includes a channel side and a utility side, and the two parts of the flow plate are counter parts and complementing each other. When the flow-plate is connected the two parts form a channel between the two counter parting channel sides. The channel includes curved obstacles, sidewalls and channel floors. The curved obstacles are lined up in parallel rows separated by sidewalls, the backside of the rows of curved obstacles have deep machined grooves making the obstacles hollow for heat transfer fluids on utility sides. A flow-plate section and a flow module are also disclosed.

Abstract: A centrifugal separator includes a frame and a drive member configured to rotate a rotating part in relation to the frame around an axis of rotation. The rotating part includes a centrifuge rotor enclosing a separation space. The centrifuge rotor is adjoined to a hollow spindle supported by the frame by at least one bearing device. The interior of the hollow spindle is in thermal contact with the at least one bearing device and further includes a thermal transfer medium inlet for supplying a thermal transfer medium to said interior and a thermal transfer medium outlet for withdrawing the thermal transfer medium from the interior; and directing mechanism for directing thermal transfer medium from the thermal transfer medium inlet to the thermal transfer medium outlet in a first direction along the length of the spindle and in a second direction along the length of the spindle. The second direction is opposite the first direction.

Abstract: A tubular flow module includes at least two concentric tubes with spiral features, wherein first tube is coaxially arranged inside a second tube and each tube has a maximum diameter and a minimum diameter, wherein the maximum diameter of first tube is larger than the minimum diameter of second tube, defining a flow path for fluids between first and second tubes. A tubular flow module system and use of the tubular flow module is also disclosed.

Abstract: A clamping device includes two end plates, disc springs, a grid of pistons, and tension rods. Each of the two end plates defines a plate area located within a perimeter thereof. The clamping device has piles of disc springs arranged as a grid of springs threaded on respective ones of the grid of pistons. The piles of disc springs is distributed and supported over the plate area on one of the two end plates. The grid of springs is positioned inwardly from the tension rods. The grid of springs is positioned to distribute clamping forces on one or more flow module plates, on one or more reactor plates, on one or more heat exchanger plates or on combinations of one or more flow module plates, one or more reactor plates, or on one or more heat exchanger plates, which plates are placed between the two end plates.

Abstract: A pump arrangement comprising two pump units, each pump unit comprising a pumping cylinder, a reciprocally movable pumping piston, said pumping piston delimiting a pumping chamber in the pumping cylinder in communication with a pump port for fluids, an actuator connected to the pumping piston, and determining a value dependent on the position of the pumping piston in the pumping cylinder, said pump arrangement further comprises a inlet and delivery valves connecting the pump port of each pump unit to a source line and a delivery line for pumped fluids, wherein the pump arrangement comprises at least one regulating unit the flow of the pumped fluids based on the value dependent on the positions of the pumping pistons in the pump units. Also a system comprising such a pump arrangement and a method for pumping fluids in said pump arrangement.