Patent number: 6239286
Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that: a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group and the resulting compound of formula (II) is transformed in the presence of an oxidising agent in a reaction medium with pH above 7, into the compound of formula (I), or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed in the presence of an oxidising agent, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or
Type:
Grant
Filed:
May 15, 2000
Date of Patent:
May 29, 2001
Assignee:
Sanofi-Synthelabo
Inventors:
Attila Kis-Tamás, Csaba Huszár, Bertrand Castro, Attila Németh, Péter Aranyosi, Károly Gyüre, István Mészáros, Ilona Dervalicsné Zrínyi, Katalin Dubovszki, Lajosné Páli, Antal Gajáry, Attila Supic, Zsuzsanna Nád, Zoltán Makovi, Endre Kollár, Zsuzsanna Csetriné Hári, Ágnes Kunsztné Kárász, Erzsébet Bognár
Patent number: 6211382
Abstract: Process for the preparation of compounds of formula (I) wherein R means hydrogen atom, or C1-6 alkyl group, or C7-12 aralkyl group or phenyl group, characterised in that a) the compound of formula (III) is reacted with a compound of formula (IV) wherein X means halogen atom or C1-5 alkoxy group or hydroxyl group, and the resulting compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I) or b) the compound of formula (III) is reacted with an anhydride of general formula (V) and the resulting compound of formula (II) transformed, in a reaction medium with pH above 7, into the compound of formula (I), or c) a compound of formula (II) is transformed, in a reaction medium with pH above 7, into the compound of formula (I), and if desired, the resulting compounds of formula (I), before or after isolation, are transformed into acid addition salts, or the compounds of formula (I) are liberated from their acid addition salts.
Type:
Grant
Filed:
April 13, 2000
Date of Patent:
April 3, 2001
Assignee:
Sanofi-Synthelabo
Inventors:
Csaba Huszár, Attila Kis-Tamás, Attila Németh, Zsuzsanna Nád, Zoltán Makovi, Antal Gajáry, Endre Kollár, Péter Aranyosi, Károly Gyüre, István Mészáros, Zsuzsanna Csetriné Hári, Attila Supic, Ilona Dervalicsne Zrinyi, Katalin Dubovszki, Lajosné Páli, Ágnes Kunsztné Kárász, Erzsébet Bognár
