Patents by Inventor Katalin Medzihradszky

Katalin Medzihradszky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein O-sulfonation
    Publication number: 20070059771
    Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.
    Type: Application
    Filed: November 9, 2006
    Publication date: March 15, 2007
    Applicants: Regents of the University of California, Yeda Research and Development Co., Ltd. at the Weizman Institute of Science
    Inventors: Alma Burlingame, Katalin Medzihradszky, Zsuzsanna Darula, Eran Perlson, Michael Fainzilber, Robert Chalkley, Darren Tyson, Ralph Bradshaw
  • Protein O-sulfonation
    Publication number: 20050054020
    Abstract: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference between the first and second physiological conditions. Predetermined changes in physiological conditions are used to infer specific changes in O-sulfonation. Proteins are modified by introducing a predetermined change in O-sulfonation at a serine or threonine residue of the protein, and optionally, detecting a resultant change in O-sulfonation. These methods include introducing or increasing O-sulfonation, eliminating or reducing O-sulfonation; and derivatizing or substituting O-sulfonation.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 10, 2005
    Inventors: Alma Burlingame, Katalin Medzihradszky, Zsuzsanna Darula, Eran Perlson, Michael Fainzilber, Robert Chalkley, Darren Tyson, Ralph Bradshaw
  • Compositions and methods for the identification and synthesis of sialyltransferases
    Patent number: 5962294
    Abstract: DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of sialyltransferase.
    Type: Grant
    Filed: August 4, 1993
    Date of Patent: October 5, 1999
    Assignees: The Regents of the University of California, Amgen, Inc.
    Inventors: James C. Paulson, Xiaohong Wen, Brian Livingston, William Gillespie, Sorge Kelm, Alma L. Burlingame, Katalin Medzihradszky
  • Compositions and methods for producing sialyltransferases
    Patent number: 5858751
    Abstract: DNA isolates coding for sialyltransferase which contain a conserved region of homology and methods of obtaining such DNA are provided, together with expression systems for recombinant production of the various sialyltransferases.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: January 12, 1999
    Assignee: The Regents of the University of California
    Inventors: James C. Paulson, Xiaohong Wen, Brian Livingston, Alma L. Burlingame, Katalin Medzihradszky, Sorge Kelm, William Gillespie