Patents by Inventor Katalin Olasz

Katalin Olasz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of polypeptides
    Patent number: 9416164
    Abstract: New methods for the production of recombinant polypeptides from inclusion bodies are disclosed. Modulation of the cell culture conditions positively affects the yield of the recombinant polypeptide in active form. In one aspect, the methods comprise (a) cultivating a host cell at a first temperature, the host cell comprising a nucleic acid encoding a recombinant polypeptide, (b) lowering the cultivation temperature from the first temperature to a second temperature, and (c) cultivating the host cell at the second temperature.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: August 16, 2016
    Assignee: Richter Gedeon Nyrt.
    Inventors: Ferenc Felföldi, Katalin Olasz, József Kozma
  • METHOD FOR THE PRODUCTION OF POLYPEPTIDES
    Publication number: 20150044721
    Abstract: New methods for the production of recombinant polypeptides from inclusion bodies are disclosed. Modulation of the cell culture conditions positively affects the yield of the recombinant polypeptide in active form. In one aspect, the methods comprise (a) cultivating a host cell at a first temperature, the host cell comprising a nucleic acid encoding a recombinant polypeptide, (b) lowering the cultivation temperature from the first temperature to a second temperature, and (c) cultivating the host cell at the second temperature.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 12, 2015
    Applicant: Rochter Gedeon Nyrt.
    Inventors: Ferenc Felföldi, Katalin Olasz, József Kozma
  • Process for the synthesis of 9?-hydroxy-steroids
    Patent number: 8367394
    Abstract: The present invention relates to a novel selective synthesis of 9?-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A?- is —CH2—CH2— or —CH?CH— group—by the bioconversion of compounds of the general formula (II) (II) wherein the meaning of -A-A?- is —CH2—CH2— or —CH?CH— group—by using Nocardia farcinica bacterium strain, deposition number of which is NCAIM (P)—B 001342, as hydroxylating microorganism in the bioconversion.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: February 5, 2013
    Assignee: Richter Gedeon Nyrt.
    Inventors: Katalin Olasz, Anikó Tegdes, Valéria Gancsos, Gábor Hantos, Kálmán Könczöl, Gabor Balogh, Sándor Erdélyi
  • PROCESS FOR THE SYNTHESIS OF 9A-HYDROXY-STEROIDS
    Publication number: 20100209967
    Abstract: The present invention relates to a novel selective synthesis of 9?-hydroxy-steroid derivatives of the general formula (I) (I)—wherein the meaning of -A-A?- is —CH2—CH2— or —CH?CH— group—by the bioconversion of compounds of the general formula (II) (II) wherein the meaning of -A-A?- is —CH2—CH2— or —CH?CH— group—by using Nocardia farcinica bacterium strain, deposition number of which is NCAIM (P)-B 001342, as hydroxylating microorganism in the bioconversion.
    Type: Application
    Filed: June 30, 2008
    Publication date: August 19, 2010
    Inventors: Katalin Olasz, Anikó Tegdes, Valéria Gancsos, Gábor Hantos, Kálmán Könczöl, Gabor Balogh, Sándor Erdélyi
  • Process for dehydrogenation of azaandrostane compounds
    Patent number: 6762302
    Abstract: The invention relates to a process for the production of compounds of general formula (I), wherein R1 is a —NH-tert-butyl group or a 4-methyl-piperidino group, by bioconversion of compounds of general formula (II), wherein R1 is as described above, using a biocatalyst having steroid-&Dgr;1-dehydrogenase enzyme activity, wherein the activity of the enzyme needed for the bioconversion is produced by induction.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: July 13, 2004
    Assignee: Gedeon Richter, Ltd.
    Inventors: Katalin Olasz, Ágnes Pécsne Rázsó, István Barthó, Mónika Berta Hériné, Tamás Dávényi, Gábor Hantos
  • Process for dehydrogenation of azaandros tane compounds
    Publication number: 20030215902
    Abstract: The invention relates to a process for the production of compounds of general formula (I), wherein R1 is a —NH-tert-butyl group or a 4-methyl-piperidino group, by bioconversion of compounds of general formula (II), wherein R1 is as described above, using a biocatalyst having steroid-&Dgr;1-dehydrogenase enzyme activity, wherein the activity of the enzyme needed for the bioconversion is produced by induction.
    Type: Application
    Filed: May 6, 2003
    Publication date: November 20, 2003
    Applicant: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Katalin Olasz, Agnes Pecsne Razso, Istvan Bartho, Monika Berta Herine, Tamas Devenyi, Gabor Hantos