Abstract: A heat not burn (HNB) consumable comprising a plant product formed into a planar slab (2) such that the consumable has a substantially rectangular transverse cross section. The planar slab of plant product may dosed with an aerosol former and may comprise a hydrophobic or liquid-impermeable outer coating. The consumable may further comprise a rectangular slab filter (4). The plant product may be formed into a cuboid brick (9) having a hollow core (10), with a core heating element in the hollow core.

Abstract: A heat not burn consumable comprising a plant product interspersed with a thermally conductive material in alternating layers such as radially or circumferentially alternating layers. The thermally conductive material may comprise at least one tubular element or may have a spiral configuration. The thermally conductive material may form spokes within the plant product. A heating element may abut a first longitudinal end face of the consumable with a longitudinally-extending conductive element which protruding axially from the longitudinal end face. The plant product may have a smooth surface and the thermally conductive material may be textured. The layers of thermally conductive material may have a grid configuration or a boustrophedonic configuration.

Abstract: The present disclosure relates to an aerosol-forming article comprising: an aerosol-forming substrate; and a filter element having a hollow bore extending from the downstream axial end of the substrate to the downstream axial end of the article.

Abstract: A heat not burn consumable (1) comprising a plant product (5) interspersed with a thermally conductive material in alternating layers such as radially or circumferentially alternating layers. The thermally conductive material may comprise at least one tubular element or may have a spiral configuration. The thermally conductive material may form spokes (4A-4E) within the plant product. A heating element may abut a first longitudinal end face (2) of the consumable (1) with a longitudinally-extending conductive element (6) which protruding axially from the longitudinal end face (2). The plant product (5) may have a smooth surface and the thermally conductive material (4) may be textured. The layers of thermally conductive material may have a grid configuration or a boustrophedonic configuration.

Abstract: A lid for an assay. The lid including a peg coupled to the lid. The peg including a first end coupled to the lid, a second end opposite the first end, a longitudinal axis that extends between the first end and the second end, a first portion extending from the first end towards the second end and having a first outer dimension, a second portion extending from the second end towards the first end and having a second outer dimension, and a third portion positioned between the first portion and the second portion, the third portion having a third outer dimension that is smaller than the first outer dimension and greater than the second outer dimension, a surface of the third portion defining a step between the first end and the second end.

Abstract: The present disclosure is directed to methods of treatment, including treatment of a myopathy by administering to a subject in need thereof an elastase inhibitor in combination with a glucocorticoid. The present disclosure is also directed to pharmaceutical compositions that include an elastase inhibitor that can be used in such treatment.

Abstract: The present disclosure is directed to methods of treatment, including treatment of a myopathy by administering to a subject in need thereof an elastase inhibitor in combination with a glucocorticoid. The present disclosure is also directed to pharmaceutical compositions that include an elastase inhibitor that can be used in such treatment.

Abstract: The present disclosure is directed to methods of treatment, including treatment of a myopathy by administering to a subject in need thereof an elastase inhibitor in combination with a glucocorticoid. The present disclosure is also directed to pharmaceutical compositions that include an elastase inhibitor that can be used in such treatment.

Abstract: The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.

Abstract: The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.