Patents by Inventor Kate Loughney

Kate Loughney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for modulating the activity of PDE5
    Publication number: 20060222647
    Abstract: The present invention provides agents such as agonists, antibodies, antagonists or inhibitors to modulate the activity of PDE5 proteins. These compositions and methods are useful for the diagnosis or treatment of conditions associated with the presence, the deficiency, altered levels, or altered activity of PDE5 proteins.
    Type: Application
    Filed: January 28, 2003
    Publication date: October 5, 2006
    Inventors: Joseph Beavo, Jackie Corbin, Kenneth Ferguson, Sharron Francis, Ann Kadlecek, Linda McAllister-Lucas, Kate Loughney, William Sonnenburg, Melissa Thomas, Sergei Rybalkin
  • cGMP-binding, cGMP-specific phosphodiesterase materials and methods
    Publication number: 20060216809
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Application
    Filed: December 21, 2005
    Publication date: September 28, 2006
    Applicants: ICOS CORPORATION
    Inventors: Joseph Beavo, Jackie Corbin, Kenneth Ferguson, Sharron Francis, Ann Kadlecek, Kate Loughney, Linda McAllister-Lucas, William Sonnenburg, Melissa Thomas
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Publication number: 20050196833
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding. cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Application
    Filed: January 28, 2003
    Publication date: September 8, 2005
    Inventors: Joseph Beavo, Jackie Corbin, Kenneth Ferguson, Sharron Francis, Ann Kadlecek, Linda McAllister-Lucas, Kate Loughney, William Sonnenburg, Melissa Thomas
  • Atr-2 cell cycle checkpoint
    Publication number: 20050112643
    Abstract: Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptides, and binding partners of the Atr-2 polypeptides.
    Type: Application
    Filed: September 30, 2004
    Publication date: May 26, 2005
    Inventors: Kate Loughney, Kathleen Keegan
  • Phosphodiesterase 10
    Patent number: 6864070
    Abstract: The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE 10, and more particularly, binding partners that modulate PDE10 enzyme activity.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: March 8, 2005
    Assignee: Icos Corporation
    Inventor: Kate Loughney
  • Phosphodiesterase 10
    Publication number: 20050009062
    Abstract: The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE 10, and more particularly, binding partners that modulate PDE10 enzyme activity.
    Type: Application
    Filed: May 11, 2004
    Publication date: January 13, 2005
    Inventor: Kate Loughney
  • ATR-2 cell cycle checkpoint
    Patent number: 6815532
    Abstract: Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptides, and binding partners of the Atr-2 polypeptides.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: November 9, 2004
    Assignee: ICOS Corporation
    Inventors: Kate Loughney, Kathleen S. Keegan
  • Phosphodiesterase 10
    Patent number: 6734003
    Abstract: The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: May 11, 2004
    Assignee: Icos Corporation
    Inventor: Kate Loughney
  • Phosphodiesterase 8A
    Publication number: 20030215919
    Abstract: The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE8 polypeptides.
    Type: Application
    Filed: May 19, 2003
    Publication date: November 20, 2003
    Inventor: Kate Loughney
  • Phosphodiesterase 10
    Publication number: 20030148378
    Abstract: The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
    Type: Application
    Filed: December 20, 2001
    Publication date: August 7, 2003
    Applicant: ICOS Corporation
    Inventor: Kate Loughney
  • Phosphodiesterase 8A
    Patent number: 6566087
    Abstract: The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE8 polypeptides.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: May 20, 2003
    Assignee: ICOS Corporation
    Inventor: Kate Loughney
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Publication number: 20030054992
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Application
    Filed: April 3, 2002
    Publication date: March 20, 2003
    Applicant: ICOS Corporation
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Phosphodiesterase 10
    Publication number: 20030044950
    Abstract: The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE 10, and more particularly, binding partners that modulate PDE10 enzyme activity.
    Type: Application
    Filed: February 26, 2002
    Publication date: March 6, 2003
    Applicant: ICOS Corporation
    Inventor: Kate Loughney
  • ATR-2 cell cycle checkpoint
    Publication number: 20030023055
    Abstract: Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptides, and binding partners of the Atr-2 polypeptides.
    Type: Application
    Filed: September 21, 2001
    Publication date: January 30, 2003
    Applicant: ICOS Corporation
    Inventors: Kate Loughney, Kathleen S. Keegan
  • Phosphodiesterase 10
    Patent number: 6350603
    Abstract: The present invention provides novel human PDE10 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE10 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE10 polypeptides. The invention further provides methods to identify binding partners of PDE10, and more particularly, binding partners that modulate PDE10 enzyme activity.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: February 26, 2002
    Assignee: ICOS Corporation
    Inventor: Kate Loughney
  • ATR-2 cell cycle checkpoint
    Patent number: 6344549
    Abstract: Polynucleotides encoding novel Atr-2 cell cycle checkpoint polypeptides are disclosed, along with expression constructs comprising the polynucleotides, host cells transformed with the expression constructs, methods to make the Atr-2 polypeptides using the host cells, Atr-2 polypeptides, and binding partners of the Atr-2 polypeptides.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: February 5, 2002
    Assignee: ICOS Corporation
    Inventors: Kate Loughney, Kathleen S. Keegan
  • Phosphodiesterase 8A
    Patent number: 6133007
    Abstract: The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE8 polypeptides.
    Type: Grant
    Filed: October 16, 1998
    Date of Patent: October 17, 2000
    Assignee: ICOS Corporation
    Inventor: Kate Loughney
  • Cyclic GMP-binding, cyclic GMP-specific phosphodiesterase materials and methods
    Patent number: 6037119
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: March 14, 2000
    Assignee: Board of Regents of the University of Washington
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Antibodies to cGMP-binding, cGMP-specific phospodiesterase
    Patent number: 5955583
    Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Antibodies to the cGMP-binding, cGMP-stimulated phosphodiesterase are disclosed. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 21, 1999
    Assignees: ICOS Corporation, Board of Regents of the University of Washington, Vanderbilt University
    Inventors: Joseph A. Beavo, Jackie D. Corbin, Kenneth M. Ferguson, Sharron H. Francis, Ann Kadlecek, Kate Loughney, Linda M. McAllister-Lucas, William K. Sonnenburg, Melissa K. Thomas
  • Phosphodiesterase 8A
    Patent number: 5932465
    Abstract: The present invention provides novel human PDE8 polypeptides, polynucleotides encoding the polypeptides, expression constructs comprising the polynucleotides, host cells transformed with the expression constructs; methods for producing PDE8 polypeptides; antisense polynucleotides; and antibodies specifically immunoreactive with the PDE8 polypeptides.
    Type: Grant
    Filed: October 16, 1997
    Date of Patent: August 3, 1999
    Assignee: ICOS Corporation
    Inventor: Kate Loughney