Abstract: An ankle-foot orthosis which is capable of being worn by a user in an acquatic environment which is lightweight, water-resistant, and reduces the amount of hydrodynamic drag during motion of a leg of a user when in water. The ankle-foot orthosis can be fully customizable to the needs of the user. The ankle-foot orthosis including three protective components; a shank shell, a shin plate, and a foot shell. The ankle-foot orthosis optionally including an additional protective component; a dorsal foot plate. At least one flow passage within each of the shank shell and the foot shell. The at least one flow passage providing water drainage and air ventilation, and reducing the overall weight of the shank shell and foot shell.

Abstract: The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.

Abstract: The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.