Patents by Inventor Kate Vignali

Kate Vignali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONOCLONAL ANTIBODIES TO INTERLEUKIN 35 AND METHODS OF USE THEREOF TO INHIBIT REGULATORY T CELL FUNCTION
    Publication number: 20170073410
    Abstract: Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
    Type: Application
    Filed: November 4, 2016
    Publication date: March 16, 2017
    Inventors: Dario Vignali, Creg Workman, Lauren Collison, Kate Vignali
  • Monoclonal antibodies to interleukin 35 and methods of use thereof to inhibit regulatory T cell function
    Patent number: 9518113
    Abstract: Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: December 13, 2016
    Assignee: St. Jude Children's Research Hospital
    Inventors: Dario Vignali, Creg Workman, Lauren Collison, Kate Vignali
  • MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35
    Publication number: 20160102143
    Abstract: Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
    Type: Application
    Filed: July 10, 2015
    Publication date: April 14, 2016
    Inventors: Dario Vignali, Creg Workman, Lauren Collison, Kate Vignali
  • T effector cells modulated via interleukin 35 and methods of culturing same
    Patent number: 9217135
    Abstract: Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: December 22, 2015
    Assignee: St. Jude Children's Research Hospital
    Inventors: Dario Vignali, Creg Workman, Lauren Collison, Kate Vignali
  • Method of inhibiting regulatory T-cell activity by administering an antibody that inhibits interleukin 35
    Patent number: 8784807
    Abstract: Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: July 22, 2014
    Assignee: St. Jude Children's Research Hospital
    Inventors: Dario Vignali, Creg Workman, Lauren Collison, Kate Vignali
  • MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35
    Publication number: 20140170750
    Abstract: Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
    Type: Application
    Filed: February 24, 2014
    Publication date: June 19, 2014
    Applicant: St. Jude Children's Research Hospital
    Inventors: Dario Vignali, Creg Workman, Lauren Collison, Kate Vignali
  • MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35
    Publication number: 20100136019
    Abstract: Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a subject a therapeutically effective amount of an Interleukin 35-specific binding agent, such as an antibody or small molecule inhibitor. The invention further provides methods for enhancing the immunogenicity of a vaccine or overcoming a suppressed immune response to a vaccine in a subject, including administering to the subject a therapeutically effective amount of an IL35-specific binding agent and administering to the subject a vaccine. In one embodiment the vaccine is a cancer vaccine.
    Type: Application
    Filed: September 24, 2007
    Publication date: June 3, 2010
    Inventors: Dario Vignali, Creg Workman, Lauren Collison, Kate Vignali