Patents by Inventor Kate Whyatt
Kate Whyatt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230215717Abstract: An atmospheric pressure ionisation source comprising: an ionisation chamber, comprising an aperture for receiving at least the distal end of a capillary into the ionisation chamber in use, the aperture having a capillary axis; a desolvation heater having a nozzle, for directing a stream of heated gas onto the distal end of the capillary in use, the nozzle having a nozzle axis; a corona discharge device including a corona pin having a corona axis, the corona pin for ionizing a sample in the ionisation chamber in use; and an inlet cone of a mass spectrometer arranged in the ionisation chamber, the inlet cone defining a cone entrance having a cone axis, wherein the cone axis is substantially coaxial with the corona axis and the capillary axis is substantially perpendicular to and intersects with the nozzle axis.Type: ApplicationFiled: May 5, 2021Publication date: July 6, 2023Applicant: Micromass UK LtdInventors: Arvind Rangan, Carl Chen, Steven Rocha, Enchen Guo, Nicola Lumley, David Douce, Richard Gallagher, Kate Whyatt
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Publication number: 20220384168Abstract: A method of mass spectrometry is disclosed comprising: a step (10) of analysing a reference compound in a first mass spectrometer and outputting mass spectral data in response thereto; a step (20) of analysing the reference compound in a second, different mass spectrometer and outputting mass spectral data in response thereto; and a step (30) of automatically adjusting an operational parameter, duty cycle (e.g. duty cycle of data acquisition), or acquired spectral data of at least one mass spectrometer such that, for the same (given) consumption of reference compound by the spectrometer, the statistical precision of quantification (the number of detected ions) and/or of mass measurement (the mass resolution) by the mass spectrometer is substantially the same as that of the other mass spectrometer. A similar method of ion mobility spectrometry is disclosed.Type: ApplicationFiled: October 6, 2020Publication date: December 1, 2022Applicant: Micromass UK LimitedInventors: Jason Lee Wildgoose, Martin Raymond Green, Keith Richardson, Daniel James Kenny, David Gordon, Kate Whyatt
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Patent number: 10679840Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 ?L/min.Type: GrantFiled: January 24, 2019Date of Patent: June 9, 2020Assignee: Micromass UK LImitedInventors: Stevan Bajic, David Gordon, Daniel James Kenny, Richard Barrington Moulds, Stephen O'Brien, Ian Trivett, Kate Whyatt
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Publication number: 20190244800Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 ?L/min.Type: ApplicationFiled: January 24, 2019Publication date: August 8, 2019Applicant: Micromass UK LimitedInventors: Stevan Bajic, David Gordon, Daniel James Kenny, Richard Barrington Moulds, Stephen O'Brien, Ian Trivett, Kate Whyatt
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Patent number: 10325764Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.Type: GrantFiled: December 11, 2017Date of Patent: June 18, 2019Assignee: MICROMASS UK LIMITEDInventors: David Gordon, Daniel James Kenny, Howard Read, Kate Whyatt
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Patent number: 10236171Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 ?L/min.Type: GrantFiled: September 17, 2014Date of Patent: March 19, 2019Assignee: MICROMASS UK LIMITEDInventors: Stevan Bajic, David Gordon, Daniel James Kenny, Richard Barrington Moulds, Stephen O'Brien, Ian Trivett, Kate Whyatt
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Publication number: 20180102241Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.Type: ApplicationFiled: December 11, 2017Publication date: April 12, 2018Inventors: David Gordon, Daniel James Kenny, Howard Read, Kate Whyatt
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Patent number: 9842727Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.Type: GrantFiled: September 17, 2014Date of Patent: December 12, 2017Assignee: Micromass UK LimitedInventors: David Gordon, Daniel James Kenny, Howard Read, Kate Whyatt
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Patent number: 9659760Abstract: A method of Electrospray ionization is disclosed comprising passing a sample liquid through a liquid chromatography column, monitoring a liquid chromatography back pressure and varying a voltage applied to an Electrospray ionization source electrode in dependence upon said monitored liquid chromatography back pressure.Type: GrantFiled: September 17, 2014Date of Patent: May 23, 2017Assignee: Micromass UK LimitedInventors: David Gordon, Alexander Hooper, Daniel James Kenny, Richard Barrington Moulds, David Pugh, Kate Whyatt
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Publication number: 20160300702Abstract: A method of automatically performing a routine to check the operational state of a mass spectrometer is disclosed wherein the method is performed automatically as a start-up routine upon switching ON the mass spectrometer. The method comprises automatically generating a vacuum within one or more vacuum chambers of a mass spectrometer and automatically generating first ions using an internal ion source, wherein the internal ion source is located within a vacuum chamber of the mass spectrometer or is located within a chamber downstream from an atmospheric pressure interface, and detecting at least some of the first ions or second ions derived from the first ions. The method further comprises automatically determining whether or not the mass spectrometer is in a correct operational state.Type: ApplicationFiled: September 17, 2014Publication date: October 13, 2016Inventors: David Gordon, Daniel James Kenny, Howard Read, Kate Whyatt
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Publication number: 20160233071Abstract: A method of Electrospray ionisation is disclosed comprising passing a sample liquid through a liquid chromatography column, monitoring a liquid chromatography back pressure and varying a voltage applied to an Electrospray ionisation source electrode in dependence upon said monitored liquid chromatography back pressure.Type: ApplicationFiled: September 17, 2014Publication date: August 11, 2016Inventors: David Gordon, Alexander Hooper, Daniel James Kenny, Richard Barrington Moulds, David Pugh, Kate Whyatt
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Publication number: 20160225601Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 ?L/min.Type: ApplicationFiled: September 17, 2014Publication date: August 4, 2016Inventors: Stevan Bajic, David Gordon, Daniel James Kenny, Richard Barrington Moulds, Stephen O'Brien, Ian Trivett, Kate Whyatt