Patents by Inventor Katelyn Arnold

Katelyn Arnold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sulfated oligosaccharides having anti-inflammatory activity
    Patent number: 11865137
    Abstract: Provided herein are small molecule compounds, including non-anticoagulant heparan sulfate oligosaccharide molecules, having anti-inflammatory properties and capable of interacting with high mobility group box 1 (HMGB1) proteins in a manner sufficient to affect an interaction between the HMGB1 protein and a receptor for advanced glycation end products (RAGE). Also provided herein are methods of treating Paracetamol (APAP) overdose in subjects.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: January 9, 2024
    Assignees: The University of North Carolina at Chapel Hill, The Research Foundation for the State University of New York
    Inventors: Katelyn Arnold, Ding Xu, Yongmei Xu, Rafal Pawlinski, Jian Liu
  • HEPARAN SULFATE (HS) OLIGOSACCHARIDES EFFECT IN LIVER ISCHEMIA REPERFUSION INJURY
    Publication number: 20220265699
    Abstract: Disclosed is a method of treating liver ischemia reperfusion (I/R) injury in a subject. In some aspects, the method comprises providing a subject suffering from liver I/R injury or at risk of suffering liver I/R injury; and administering to the subject one or more heparan sulfate (HS) compounds. In some aspects, the one or more HS compounds comprises about 5 to about 18 saccharide units, optionally about 12 to about 18 saccharide units. In some aspects, the one or more HS compounds comprises about 12 saccharide units.
    Type: Application
    Filed: May 13, 2022
    Publication date: August 25, 2022
    Inventors: Katelyn Arnold, Jian Liu, Rafal Pawlinski, Brian Cooley
  • SULFATED OLIGOSACCHARIDES HAVING ANTI-INFLAMMATORY ACTIVITY
    Publication number: 20210169923
    Abstract: Provided herein are small molecule compounds, including non-anticoagulant heparan sulfate oligosaccharide molecules, having anti-inflammatory properties and capable of interacting with high mobility group box 1 (HMGB1) proteins in a manner sufficient to affect an interaction between the HMGB1 protein and a receptor for advanced glycation end products (RAGE). Also provided herein are methods of treating Paracetamol (APAP) overdose in subjects.
    Type: Application
    Filed: November 5, 2018
    Publication date: June 10, 2021
    Inventors: Katelyn Arnold, Ding Xu, Yongmei Xu, Rafal Pawlinski, Jian Liu