Abstract: Systems and methods may be utilized to obtain and evaluate data from various information resources associated with a diagnostic testing business for the purpose of identifying at-risk clients. A set of risk indicators is defined. Each risk indicator relates to a type of event that is determined to be indicative of client risk, and about which data may be obtained from information resources associated with the testing process. Data is obtained from the various information resources through respective interfaces and is stored in a risk indicator database. A reporting application associated with the risk indicator database applies score generation rules to the risk indicator data associated with each risk indicator to generate a risk score associated with each risk indicator for each client. The risk scores may then be evaluated to identify at-risk clients and to identify systemic problems of the organization that occur across many clients.