Abstract: Novel 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 2-(substituted benzyl)-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-ones and 4-fluoro-N-(4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)benzamide compounds, identified as COX-2 inhibitors, are useful as anti-inflammatory and pain agents.

Abstract: Novel 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 1-(2-(substituted phenyl)-2-oxoethyl)-4-methylpyridin-1-ium bromide derivatives compounds, are useful as anti-tubercular agents.

Abstract: Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds that are 5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents.

Abstract: Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds that are 5-(substitutedphenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents.

Abstract: Compounds for treating a microbial and/or bacterial infection and, particularly, to compounds that are 5-(substituted phenyl)-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-microbial or anti-bacterial agents.

Abstract: Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are (E)-1-(2-(4-substitutedphenyl)-2-oxoethyl)-4-((hydroxyimino)methyl)pyridinium bromides and their use as anti-tubercular agents.

Abstract: Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are 4-cyano-1-(2-oxo-2-(substituted phenyl)ethyl)pyridin-1-ium bromides and their use as anti-tubercular agents.

Abstract: Methods of treating cancer in a patient by administering ethyl-1-(substituted benzoyl)-5-methylpyrrolo[1,2-a]quinoline-3-carboxylates to a patient in need thereof.

Abstract: Compounds for treating an inflammatory disease, disorder, or condition and, particularly, to compounds that are 5-(substitutedphenyl)-7-imino-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione analogues and their use as anti-inflammatory agents.

Abstract: Novel arylhydrazones derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The arylhydrazones derivative compounds are useful as anti-tubercular agents.

Abstract: 7-Imino-5-(1H-indol-3-yl)-1,3-substituted-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The present compounds, identified as COX-2 inhibitors, are useful as anti-inflammatory agents.

Abstract: Novel arylhydrazones derivatives, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The arylhydrazones derivative compounds are useful as anti-tubercular agents.

Abstract: The liposome encapsulating cysteamine and resveratrol in separate compartments is a liposome having a lipid or lipid bilayer shell and a hydrophilic core. The hydrophilic core contains a hydrophilic antioxidant, which in some embodiments, is cysteamine or pharmaceutically acceptable salts thereof, such as hydrochlorides or bitartrates. The region surrounding the hydrophilic core contains lipids or phospholipids and at least one lipophilic antioxidant, such as resveratrol. The lipophilic contents of the liposome surrounding the hydrophilic core tend to partition from the hydrophilic core and associate with the lipid or lipid bilayer shell. In some embodiments, the liposome composition may be used for the treatment of acute lung injury or acute respiratory distress syndrome, the antioxidants helping to reduce or alleviate inflammation, whether resulting from disease or trauma.

Abstract: Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are substituted 1,3,4-oxadiazole derivatives and their use as anti-tubercular agents are provided.

Abstract: Compounds for treating a microbial infection and/or tuberculosis and, particularly, antimicrobial and/or antitubercular compounds that are 3-cyano 4,5-diphenyl furan-2-carboxamides and their use as antimicrobial and/or antitubercular agents are provided.

Abstract: Compounds for treating tuberculosis and, particularly, anti-tubercular compounds that are (6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones and their use as anti-tubercular agents are provided.

Abstract: Novel oxoimidazolidine derivative compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The oxoimidazolidine derivative compounds are useful as anti-tubercular agents.

Abstract: Novel 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, identified as adenosine A3 receptor (A3AR) modulators, are useful as anti-inflammation, anticancer and/or anti-ischemic agents, and as agents for treating other adenosine overexpression related conditions including rheumatoid arthritis, psoriasis and fatty liver diseases, inflammation, pain, and number of pathological conditions of the central and peripheral nervous systems.

Abstract: Compounds for treating preventing malaria and, particularly, to larvicidal agents that are 7-isopropyl 1-ethyl/methyl 3-(substituted benzoyl)-2-substituted indolizine-1,7-dicarboxylates derivatives and their use as larvicidal agents.

Abstract: Compounds for treating tuberculosis and, particularly, to anti-tubercular compounds that are 5-(1H-indol-3-yl)-1,3-substituted-7-thioxo-7,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione derivatives and their use as anti-tubercular agents. Each compound may have the formula I: or a pharmaceutically acceptable salt or tautomer thereof, wherein: R1 is H or CH3; R2 is H or CH3; and X is O or S.