Patents by Inventor Katharina Aulinger Fuchs

Katharina Aulinger Fuchs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying inhibitors of DHODH
    Patent number: 7247736
    Abstract: The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.
    Type: Grant
    Filed: November 10, 2004
    Date of Patent: July 24, 2007
    Assignee: 4SC AG
    Inventors: Johann Leban, Bernd Kramer, Roland Baumgartner, Katharina Aulinger-Fuchs, Stefan Tasler
  • Modulation of Pathogenicity
    Publication number: 20070093534
    Abstract: The present invention relates to the use of compounds of the general Formula (XIII): wherein A7 is C?O, C?S, SO2, CH—OR13, C?NR12, or CH2—CHOR13; A8 is C(R14)2, O, S, or NR12; A9 is C?O, C?S, SO2, CH—OR13, C?NR12, or CH2—CHOR13; m is 0, or 1 q is 0, or 1 r is 0, or 1 R12 is H, CH3, CH2—CH3, C6H5, OCH3, OCH2—CH3, OH, or SH; R13 is H, CH3, or CH2—CH3; R14 is H, alkyl, alkoxy, OH, or SH;
    Type: Application
    Filed: November 16, 2006
    Publication date: April 26, 2007
    Inventors: Aldo Ammendola, Katharina Aulinger-Fuchs, Astrid Gotschlich, Bernd Kramer, Martin Lang, Wael Saeb, Udo Sinks, Andreas Wuzik
  • Method of identifying inhibitors of DHODH
    Publication number: 20070027193
    Abstract: The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH. Furthermore, the present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains an aromatic ring system as a core structure, a group capable of interacting with residues His 56 and/or Tyr 356 of subsite 3 of the ubiquinone binding site of DHODH and a group capable of interacting hydrophobically with structural elements of subsite 1 of the ubiquinone binding site of DHODH.
    Type: Application
    Filed: November 10, 2004
    Publication date: February 1, 2007
    Applicant: 4SC AG
    Inventors: Johann Leban, Bernd Kramer, Roland Baugartner, Katharina Aulinger-Fuchs, Stefan Tasler
  • Compounds for the treatment of protozoal diseases
    Patent number: 6949567
    Abstract: The invention relates to new diphenylurea having the formula (I) or a salt thereof, where Y is C?O, C?S, C?NH, (C?O)2 or SO2; and to processes for the preparation of these compounds and to their use in the treatment of protozoal diseases and to diseases where the inhibition of intracellular protein-degradation pathways is of benefit.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: September 27, 2005
    Assignee: 4SC AG
    Inventors: Andrea Aschenbrenner, Katharina Aulinger Fuchs, Matthias Dormeyer, Gabriel Garcia, Bernd Kramer, Jürgen Kraus, Rolf Krauss, Johan Leban, Stefano Pegoraro, Wael Saeb, Kristina Wolf
  • Heterocyclic compounds as pharmaceutically active compounds
    Publication number: 20050143382
    Abstract: The present invention relates to furazanopyrazine derivatives of the general formula (I): wherein: R? represents —NR1R2 or —OR9 R? represents —NR5—NR3R4, —NR5—ORb, —O—NR3R4; wherein R1 to R9 in formula (I) represent independently of each other a variety of different substituents comprising alkyl, aryl, aralkyl, alkylaryl, heteroaryl groups and monofunctional moieties.
    Type: Application
    Filed: November 2, 2004
    Publication date: June 30, 2005
    Applicant: 4SC AG
    Inventors: Katharina Aulinger-Fuchs, Thomas Herz, Rolf Krauss, Michael Kubbatat, Martin Lang, Christoph Schachtele, Frank Totzke
  • Modulation of pathogenicity
    Publication number: 20040235914
    Abstract: The present invention relates to the use of compounds of the general Formula (XIII): 1
    Type: Application
    Filed: May 6, 2004
    Publication date: November 25, 2004
    Applicant: 4 SC AG
    Inventors: Aldo Ammendola, Katharina Aulinger-Fuchs, Astrid Gotschlich, Bernd Kramer, Martin Lang, Wael Saeb, Udo Sinks, Andreas Wuzik
  • Modulation of pathogenicity
    Publication number: 20040063765
    Abstract: The present invention relates to the use of compounds of the general Formula (I): 1
    Type: Application
    Filed: May 6, 2003
    Publication date: April 1, 2004
    Applicant: 4 SC AG
    Inventors: Aldo Ammendola, Katharina Aulinger-Fuchs, Astrid Gotschlich, Bernd Kramer, Martin Lang, Wael Saeb, Udo Sinks, Andreas Wuzik
  • Compounds for the treatment of protozoal diseases
    Publication number: 20030119876
    Abstract: The invention relates to new diphenylurea having the formula (I) 1
    Type: Application
    Filed: February 26, 2002
    Publication date: June 26, 2003
    Inventors: Andrea Aschenbrenner, Katharina Aulinger Fuchs, Matthias Dormeyer, Gabriel Garcia, Bernd Kramer, Jurgen Kraus, Rolf Krauss, Johan Leban, Stefano Pegoraro, Wael Saeb, Kristina Wolf
  • Compounds for the treatment of protozoal diseases
    Publication number: 20020165236
    Abstract: Treatment of Protozoan Infections with new diphenylurea derivatives.
    Type: Application
    Filed: December 12, 2001
    Publication date: November 7, 2002
    Inventors: Andrea Aschenbrenner, Katharina Aulinger Fuchs, Matthias Dormeyer, Gabriel Garcia, Bernd Kramer, Stefano Pegoraro, Jurgen Kraus, Rolf Krauss, Hans Leban, Wael Saeb, Kristina Wolf