Patents by Inventor Katharina Schmidt-Bleek

Katharina Schmidt-Bleek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD8 T cell subsets as a biomarker for predicting non-fusion after spinal fusion surgery
    Patent number: 11802873
    Abstract: Provided herein is a method for predicting the probability of having or developing a non-fusion, wherein said method comprises determining the frequency of a subpopulation of CD8+ T cells selected from CD8+CD57+, CD8+CD28? and CD8+CD57+CD28? in a sample obtained from a patient. Also provided herein is a system for predicting the probability of having or developing a non-fusion.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: October 31, 2023
    Assignee: CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Simon Reinke, Sven Geissler, Georg Duda, Hans-Dieter Volk, Michael Fuchs, Katharina Schmidt-Bleek, Patrick Strube, Matthias Pumberger
  • CD8+T-cell subsets as markers for prediction of delayed fracture healing
    Patent number: 11639935
    Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: May 2, 2023
    Assignee: CHARITÉ UNIVERSITATSMEDIZIN BERLIN
    Inventors: Georg Duda, Hans-Dieter Volk, Simon Reinke, Christian Meisel, Christian Kleber, Sven Geissler, Katharina Schmidt-Bleek
  • CD8+T-CELL SUBSETS AS MARKERS FOR PREDICTION OF DELAYED FRACTURE HEALING
    Publication number: 20230033136
    Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.
    Type: Application
    Filed: October 2, 2022
    Publication date: February 2, 2023
    Applicant: Charite Universitätsmedizin Berlin
    Inventors: Georg DUDA, Hans-Dieter VOLK, Simon REINKE, Christian MEISEL, Christian KLEBER, Sven GEISSLER, Katharina SCHMIDT-BLEEK
  • IMMUNMODULATION FOR PREVENTION OF POOR HEALING OF MUSCULOSKELETAL INJURIES IN COMPROMISED PATIENTS
    Publication number: 20200197341
    Abstract: The present invention relates to a compound for use in a method for treating a musculoskeletal injury, wherein the compound is a regulator of the pro-inflammatory response and particularly being capable of upregulating regulatory T cells and/or M2-macrophages; and/or being capable of downregulating the biological activity of effector CD8+ cells, and further comprising the dosage regimen administering an initial dose of said compound to a patient not before 24 hours after said musculoskeletal injury.
    Type: Application
    Filed: August 31, 2018
    Publication date: June 25, 2020
    Applicant: CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Katharina SCHMIDT-BLEEK, Hans-Dieter VOLK, Sebastian WENDLER, Georg N. DUDA, Simon REINKE, Sven GEISSLER, Taimoor Hasan QAZI, Anke DIENELT, Hanna SCHELL
  • CD8 T CELL SUBSETS AS A BIOMARKER FOR PREDICTING NON-FUSION AFTER SPINAL FUSION SURGERY
    Publication number: 20200182872
    Abstract: The present invention relates to a method for predicting the probability of having or developing a non-fusion, wherein said method comprises determining the frequency of a subpopulation of CD8+ T cells selected from CD8+CD57+, CD8+CD28? and CD8+CD57+CD28? in a sample obtained from a patient. The invention further relates to a system for predicting the probability of having or developing a non-fusion.
    Type: Application
    Filed: May 29, 2018
    Publication date: June 11, 2020
    Applicant: CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Simon REINKE, Sven GEISSLER, Georg DUDA, Hans-Dieter VOLK, Michael FUCHS, Katharina SCHMIDT-BLEEK, Patrick STRUBE, Matthias PUMBERGER
  • CD8+T-CELL SUBSETS AS MARKERS FOR PREDICTION OF DELAYED FRACTURE HEALING
    Publication number: 20200116721
    Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.
    Type: Application
    Filed: December 12, 2019
    Publication date: April 16, 2020
    Applicant: Charite Universitätsmedizin Berlin
    Inventors: Georg DUDA, Hans-Dieter VOLK, Simon REINKE, Christian MEISEL, Christian KLEBER, Sven GEISSLER, Katharina SCHMIDT-BLEEK
  • CD8+T-CELL SUBSETS AS MARKERS FOR PREDICTION OF DELAYED FRACTURE HEALING
    Publication number: 20150010924
    Abstract: The present invention relates to a method for diagnosis of delayed bone fracture healing, comprising determining the frequency of a subpopulation of CD8+ cells selected from a first group comprised of CD8+CD57+, CD8+CD28? and CD8+CD28?/CD57+, in a sample obtained from a subject. The present invention further relates to a system and a kit of parts for prediction and resulting options for preventing of delayed bone fracture healing.
    Type: Application
    Filed: February 4, 2013
    Publication date: January 8, 2015
    Inventors: Georg Duda, Hans-Dieter Volk, Simon Reinke, Christian Meisel, Christian Kleber, Sven Geissler, Katharina Schmidt-Bleek