Patents by Inventor Katharine H. Cole

Katharine H. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human liver epithelial cell lines
    Patent number: 5759765
    Abstract: Immortalized cell lines derived from normal adult human liver are described which express phenotypic characteristics of normal adult liver epithelial cells. The invention further provides methods of using the immortalized cells to evaluate the cytotoxicity or carcinogenicity of a compound.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 2, 1998
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Curtis C. Harris, Katharine H. Cole, John F. Lechner, Roger Reddel
  • Human liver epithelial cell lines
    Patent number: 5665589
    Abstract: Immortalized cell lines derived from normal adult human liver are described which express phenotypic characteristics of normal adult liver epithelial cells.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: September 9, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Curtis C. Harris, Katharine H. Cole, John F. Lechner, Roger Reddel
  • Human liver epithelial cell line and culture media therefor
    Patent number: 5529920
    Abstract: The present invention relates to long term multiplication and permanent establishment of a cell line of human liver epithelial cells(hepatocytes). The human liver epithelial cell line is capable of mitotically proliferating and continuously growing in vitro under suitable environmental conditions in suitable culture media. A method of producing an immortalized human liver epithelial cell line is also disclosed. The invention also relates to serum-free cell medium developed to support long term multiplication and permanent establishment of a cell line of human liver epithelial cells.
    Type: Grant
    Filed: May 1, 1992
    Date of Patent: June 25, 1996
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Katharine H. Cole, John F. Lechner, Roger Reddel, Curtis C. Harris, Andrea M. Pfeifer
  • Cell culture medium for human liver epithelial cell line
    Patent number: 5342777
    Abstract: The present invention relates to cell medium developed to support long term multiplication and permanent establishment of a cell line of human liver epithelial cells. The medium may contain an effective cell growth promoting amount of calcium ions; an effective cell growth promoting amount of glucose; an effective amount of insulin to aid cells in glucose uptake; an effective cell growth promoting amount of hydrocortisone; an effective amount of epidermal growth factor to bind epidermal growth factor receptors on cells; an effective amount of transferrin to increase DNA synthesis in cells; an effective amount of cholera toxin to increase DNA synthesis in cells; an effective amount of triiodothyronine to increase DNA synthesis in cells; and an effective growth promoting amount of mammalian hormones and mitogenic factors, including lipoprotein, cholesterol, phospholipids and fatty acids.
    Type: Grant
    Filed: March 3, 1992
    Date of Patent: August 30, 1994
    Assignee: The United States of America as represented by the Secretary of the Dept. of Health and Human Services
    Inventors: Katharine H. Cole, John F. Lechner, Curtis C. Harris