Patents by Inventor Katherina Siewert

Katherina Siewert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF T CELL TARGET ANTIGENS
    Publication number: 20170240884
    Abstract: The present invention relates to a method of identifying a target antigen of T cells comprising (a) contacting (aa) cells expressing (i) a functional T cell receptor complex comprising predefined matching T cell receptor ? and ? chains; and (ii) a read-out system for T cell activation; with (ab) antigen-presenting cells carrying (iii) peptide libraries encoded by randomised nucleic acid sequences; and (iv) WIC molecules recognised by the T cell receptor of (i); (b) assessing T cell activation using said read-out system; (c) isolating antigen-presenting cells that are in contact with the cells in which the read-out system indicates T cell activation; (d) identifying the target antigen or the nucleic acid molecule encoding said target antigen.
    Type: Application
    Filed: May 5, 2017
    Publication date: August 24, 2017
    Inventors: Klaus Dornmair, Reinhard Hohlfeld, Jörg Prinz, Katherina Siewert, Song-Min Kim
  • Identification of T cell target antigens
    Patent number: 9678061
    Abstract: The present invention relates to a method of identifying a target antigen of T cells comprising (a) contacting (aa) cells expressing (i) a functional T cell receptor complex comprising predefined matching T cell receptor ? and ? chains; and (ii) a read-out system for T cell activation; with (ab) antigen-presenting cells carrying (iii) peptide libraries encoded by randomised nucleic acid sequences; and (iv) MHC molecules recognised by the T cell receptor of (i); (b) assessing T cell activation using said read-out system; (c) isolating antigen-presenting cells that are in contact with the cells in which the read-out system indicates T cell activation; (d) identifying the target antigen or the nucleic acid molecule encoding said target antigen.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: June 13, 2017
    Assignee: Ludwig-Maximilians-Universität München
    Inventors: Klaus Dornmair, Reinhard Hohlfeld, Jorg Prinz, Katherina Siewert, Song-Min Kim
  • IDENTIFICATION OF T CELL TARGET ANTIGENS
    Publication number: 20130195900
    Abstract: The present invention relates to a method of identifying a target antigen of T cells comprising (a) contacting (aa) cells expressing (i) a functional T cell receptor complex comprising predefined matching T cell receptor ? and ? chains; and (ii) a read-out system for T cell activation; with (ab) antigen-presenting cells carrying (iii) peptide libraries encoded by randomised nucleic acid sequences; and (iv) MHC molecules recognised by the T cell receptor of (i); (b) assessing T cell activation using said read-out system; (c) isolating antigen-presenting cells that are in contact with the cells in which the read-out system indicates T cell activation; (d) identifying the target antigen or the nucleic acid molecule encoding said target antigen.
    Type: Application
    Filed: August 5, 2011
    Publication date: August 1, 2013
    Applicant: LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
    Inventors: Klaus Dornmair, Reinhard Hohlfeld, Jorg Prinz, Katherina Siewert, Song-Min Kim