Abstract: Provided herein are methods for treatment of cystic fibrosis (CF), including for patients with class I CFTR mutations. The methods may involve administration of a recombinant adeno-associated virus (rAAV) that includes an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, or a pharmaceutical composition thereof.

Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.

Abstract: A vehicle has a thermal management system that comprises an electric power source loop comprising at least one battery. The thermal management system further comprises a heating component thermally coupled to the electric power source loop. When an ambient temperature is less than a first threshold, the heating component pre-heats the at least one battery. In exemplary embodiments, the heating component includes at least one brake resistor that is coupled to the electric power source loop.

Abstract: A vehicle has a thermal management system that comprises an electric power source loop comprising at least one battery. The thermal management system further comprises a heating component thermally coupled to the electric power source loop. When an ambient temperature is less than a first threshold, the heating component pre-heats the at least one battery. In exemplary embodiments, the heating component includes at least one brake resistor that is coupled to the electric power source loop.

Abstract: An electric vehicle has a thermal management system that comprises a common radiator, a brake resistor loop, and an electric power source loop. The brake resistor loop comprises a brake resistor and a brake resistor controller that are coupled to the common radiator. The electric power source loop comprises an electric power source coupled to the common radiator. When the brake resistor loop is determined to be in operation, the common radiator is utilized by the brake resistor loop to absorb heat generated by the brake resistor loop. When the brake resistor loop is determined to not be in operation, the common radiator is utilized by the electric power source to absorb heat generated by the electric power source loop.

Abstract: Turbine engine systems for interstage particle separation in multistage radial compressors are disclosed. The multistage radial compressor system includes an interstage region positioned between a first stage radial compressor and a second stage radial compressor. The interstage region includes a radially-outward oriented section, a longitudinally-oriented section, and a radially-inward oriented section. The radially-outward oriented section transitions to the longitudinally-oriented section at a first approximately 90-degree bend, and the longitudinally-oriented section transitions to the radially-inward oriented section at a second approximately 90-degree bend. The multistage radial compressor system further includes a particle separation system including an extraction slot and an aspiration slot located downstream from the extraction slot. The particle separation system is positioned along the interstage region outside of the air flow path.

Abstract: An electric vehicle has a thermal management system that comprises a common radiator, a brake resistor loop, and an electric power source loop. The brake resistor loop comprises a brake resistor and a brake resistor controller that are coupled to the common radiator. The electric power source loop comprises an electric power source coupled to the common radiator. When the brake resistor loop is determined to be in operation, the common radiator is utilized by the brake resistor loop to absorb heat generated by the brake resistor loop. When the brake resistor loop is determined to not be in operation, the common radiator is utilized by the electric power source to absorb heat generated by the electric power source loop.

Abstract: The present disclosure provides a method of managing thermal loads in a fuel cell vehicle. The method may comprise heating a fuel cell coolant of a fuel cell coolant loop utilizing waste heat from a fuel cell to form a heated fuel cell coolant, heating a battery coolant of a battery coolant loop utilizing waste heat from a battery to form a heated battery coolant, heating a refrigerant of a battery refrigeration loop by exchanging heat with the heated battery coolant, and superheating the refrigerant of the battery refrigeration loop by exchanging heat with the heated fuel cell coolant.

Abstract: The present disclosure provides a method of managing thermal loads in a fuel cell vehicle. The method may comprise heating a fuel cell coolant of a fuel cell coolant loop utilizing waste heat from a fuel cell to form a heated fuel cell coolant, heating a battery coolant of a battery coolant loop utilizing waste heat from a battery to form a heated battery coolant, heating a refrigerant of a battery refrigeration loop by exchanging heat with the heated battery coolant, and superheating the refrigerant of the battery refrigeration loop by exchanging heat with the heated fuel cell coolant.

Abstract: The present disclosure provides a method of managing thermal loads in a fuel cell vehicle. The method may comprise heating a fuel cell coolant of a fuel cell coolant loop utilizing waste heat from a fuel cell to form a heated fuel cell coolant, heating a battery coolant of a battery coolant loop utilizing waste heat from a battery to form a heated battery coolant, heating a refrigerant of a battery refrigeration loop by exchanging heat with the heated battery coolant, and superheating the refrigerant of the battery refrigeration loop by exchanging heat with the heated fuel cell coolant.

Abstract: The present disclosure provides a method of managing thermal loads in a fuel cell vehicle. The method may comprise heating a fuel cell coolant of a fuel cell coolant loop utilizing waste heat from a fuel cell to form a heated fuel cell coolant, heating a battery coolant of a battery coolant loop utilizing waste heat from a battery to form a heated battery coolant, heating a refrigerant of a battery refrigeration loop by exchanging heat with the heated battery coolant, and superheating the refrigerant of the battery refrigeration loop by exchanging heat with the heated fuel cell coolant.

Abstract: Turbine engine systems for interstage particle separation in multistage radial compressors are disclosed. The multistage radial compressor system includes an interstage region positioned between a first stage radial compressor and a second stage radial compressor. The interstage region includes a radially-outward oriented section, a longitudinally-oriented section, and a radially-inward oriented section. The radially-outward oriented section transitions to the longitudinally-oriented section at a first approximately 90-degree bend, and the longitudinally-oriented section transitions to the radially-inward oriented section at a second approximately 90-degree bend. The multistage radial compressor system further includes a particle separation system including an extraction slot and an aspiration slot located downstream from the extraction slot. The particle separation system is positioned along the interstage region outside of the air flow path.

Abstract: A molded game ball comprises an outer cover or surface having a mold line that mimics the seam of a conventional baseball or softball. The outer cover or surface may additionally include a stitch pattern that mimics the stitching of a conventional baseball or softball.

Abstract: There is provided a composition comprising a self-assembling membrane, wherein the self-assembling membrane comprises elastin-like polymers (ELPs) and peptide amphiphiles (PAs). Also provided is a method of forming a membrane and uses of the membrane.

Abstract: A molded game ball comprises an outer cover or surface having a mold line that mimics the seam of a conventional baseball or softball. The outer cover or surface may additionally include a stitch pattern that mimics the stitching of a conventional baseball or softball.

Abstract: A molded game ball comprises a molded outer cover having a mold line that mimics the seam of a conventional baseball or softball, and a raised stitch pattern presented along said mold line that mimics the stitching of a conventional stitched baseball or softball.

Abstract: A baseball or softball comprising a cover having an outer surface that is formed of a first material. A second material that is easier to grip than the first material is affixed to the cover in the same location as the seam on a conventional baseball or softball. The ball's outer surface is molded and stitchless, meaning that the outer covering is not made by stitching panels together. While the ball may be stitchless, it may have simulated, molded stitches. The second material, when positioned on a planar surface, comprises a continuous strip having two generally semicircular ends each integral with a pair of opposed concave sides (e.g. a FIG. 8 configuration).

Abstract: A molded game ball and process for making the same. The game ball comprises a molded outer cover having a mold line that mimics the seam of a conventional game ball and a raised stitch pattern presented along said mold line. The game ball is made by forming an outer cover in a mold that has a pattern that is positioned to mimic the inverse of the pattern of a seam of a conventional game ball. Material is then injected into an interior volume enclosed by the outer cover to form an inner core that permanently bonds with the outer cover. The outer cover of the game ball has a stitch pattern that mimics the stitching and seam of a conventional stitched game ball.

Abstract: A game ball with a cover having an outer surface that is formed of a first material. A second material, which is easier to grip than the first material, is affixed to the cover and positioned to resemble the seam of a conventional game ball. Preferably, the cover is formed from at least two panels that are coupled together along a seam. An outer surface of each panel is formed from the first material, and the second material is affixed to each panel adjacent to the seam. The invention also includes a baseball or softball with a cover having an outer surface formed of a first material, and a second material that is affixed to the outer surface in the same location as the seam on a conventional baseball or softball. The second material enhances a player's ability to grip the ball.