Abstract: A method includes: receiving a diagnosis of a medical condition; retrieving encoded guidelines for pharmaceutical treatment corresponding to the diagnosis; in response to the encoded guidelines, generating a list of recommended medications with related information; modifying the list of recommended medications, in response to personal context data obtained from at least one of a wearable device, a smart pill bottle, a patient health wallet, and an electronic health record; further modifying the list of recommended medications in response to environmental context data; generating an ordered list of recommended medications by yet further modifying the list of recommended medications in response to a patient similarity analysis; providing to a prescriber the ordered list of recommended medications; developing a logistical plan including a mode of delivery for one of the recommended medications; and programming an autonomous device to implement the mode of delivery.

Abstract: A guideline annotation method, system, and computer program product, include extracting a medical data point from a medical guideline, determining an attribute context of the medical data point, finding a related literature to the medical guideline, determining an expert practice as a difference between the medical guideline and an expert operating procedure, and annotating and outputting a new medical guideline including the related literature and the expert practice.

Abstract: Methods are provided for personalizing and optimizing a medication regime for a patient. For example a method involves generating a medication regime for one or more prescribed medications associated with a patient as input via a user interface; personalizing the generated medication regime for the patient via the user interface; generating a regime planner from the personalized medication regime for the patient via the user interface; and forwarding a reminder to the patient to take the prescribed one or more medications from the generated regime planner via the user interface, wherein the steps of the method are performed in accordance with a processor and a memory.