Publication number: 20250009917
Abstract: The present invention relates to compounds of formula (I) that have the ability to be used as metal complexes in radiotherapy. wherein A is selected from the group consisting of CO2R1, and PO3R1; B is selected from the group consisting of CO2R2, and PO3R2; R1, R2 and R3 are each independently selected from the group consisting of H and C1-C12alkyl; each Ra is independently selected from the group consisting of H, F, Cl, Br, I, CH3, CH2CH3, CH(CH3)2, OH, OCH3, OCH2CH3, CF3, OCF3, NO2, NH2, and CN; each Rb is independently selected from the group consisting of H, F, Cl, Br, I, CH3, CH2CH3, CH(CH3)2, OH, OCH3, OCH2CH3, CF3, OCF3, NO2, NH2, and CN; L is a linker having from 1 to 20 atoms in the normal chain; or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
September 29, 2022
Publication date:
January 9, 2025
Inventors:
Katherine Anne Morgan, Paul Stephen Donnelly, Christian Werner Wichmann, Andrew Mark Scott