Abstract: The present invention is directed to (?)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+) tartrate salt, a pharmaceutical composition comprising said salt, a process for making said salt, and the use of said salt in the treatment of pain.

Abstract: The present invention is directed to (?)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+) tartrate salt, a pharmaceutical composition comprising said salt, a process for making said salt, and the use of said salt in the treatment of pain.

Abstract: The present invention is directed to (?)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+)tartrate salt, a pharmaceutical composition comprising said salt, a process for making said salt, and the use of said salt in the treatment of pain.

Abstract: The present invention is directed to (?)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+)tartrate salt, a pharmaceutical composition comprising said salt, a process for making said salt, and the use of said salt in the treatment of pain.

Abstract: A dropwise liquid dispensing system is provided which includes a liquid formulation having a surface tension of less than a specific value. A tip is provided for dispensing of the liquid formulation in a dropwise fashion and an inner bottle, in communication with the tip, contains the liquid formulation, and forces the liquid formulation through the tip when compressed. The inner bottle is configured with a volume for preventing a liquid formulation from flowing out of the bottle through the tip without compression of the inner bottle. An outer bottle is provided and disposed around the inner bottle for compressing the inner bottle. The inner and outer bottles are sized for providing hydraulic advantage in compressing the inner bottle with the hydraulic advantage being manifested by the outer bottle having a greater inner surface area than an outer surface of the inner bottle.

Abstract: A multiple fluid dispensing device is provided which includes a plurality of liquid formulations with at least one formulation having a surface tension of less than a specific value. A tip is provided for dispensing of the liquid formulations in a dropwise fashion and an inner bottle, in communication with the tip, contains the liquid formulations in separate compartments, and forces the liquid formulations through the tip when compressed. The inner bottle is configured with a volume for preventing the liquid formulations from flowing out of the bottle through the tip without compression of the inner bottle. An outer bottle is provided and disposed around the inner bottle for compressing the inner bottle. The inner and outer bottles are sized for providing hydraulic advantage in compressing the inner bottle with the hydraulic advantage being manifested by the outer bottle having a greater inner surface area than an outer surface of the inner bottle.

Abstract: A dropwise liquid dispensing system is provided which includes a liquid formulation having a surface tension of less than a specific value. A tip is provided for dispensing of the liquid formulation in a dropwise fashion and an inner bottle, in communication with the tip, contains the liquid formulation, and forces the liquid formulation through the tip when compressed. The inner bottle is configured with a volume for preventing a liquid formulation from flowing out of the bottle through the tip without compression of the inner bottle. An outer bottle is provided and disposed around the inner bottle for compressing the inner bottle. The inner and outer bottles are sized for providing hydraulic advantage in compressing the inner bottle with the hydraulic advantage being manifested by the outer bottle having a greater inner surface area than an outer surface of the inner bottle.