Patents by Inventor Katherine E. Varley

Katherine E. Varley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED SEQUENCING TO DETECT AND QUANTIFY LOW LEVELS OF METHYLATED DNA
    Publication number: 20240117415
    Abstract: Disclosed herein are compositions and methods to detect and quantify low levels of methylated DNA in biological samples.
    Type: Application
    Filed: September 4, 2020
    Publication date: April 11, 2024
    Inventors: Katherine E. Varley, Ryan Miller, Jeffery A. Greenland
  • CAPTURE METHODOLOGIES FOR CIRCULATING CELL FREE DNA
    Publication number: 20220017893
    Abstract: A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target nucleic acid sequences are unknown.
    Type: Application
    Filed: October 1, 2021
    Publication date: January 20, 2022
    Inventors: Katherine E. Varley, D. Troy Moore, Randall Bachmeyer, David Kloske
  • Capture methodologies for circulating cell free DNA
    Patent number: 11162094
    Abstract: A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target nucleic acid sequences are unknown.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: November 2, 2021
    Assignee: KAILOS GENETICS, INC.
    Inventors: Katherine E. Varley, D. Troy Moore, Randall Bachmeyer, David Kloske
  • Method for multiplexed nucleic acid patch polymerase chain reaction
    Patent number: 11111514
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: September 7, 2021
    Assignee: Washington University
    Inventors: Robi M. Mitra, Katherine E. Varley
  • METHOD OF TREATING BREAST CANCER
    Publication number: 20190375806
    Abstract: The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts.
    Type: Application
    Filed: August 27, 2019
    Publication date: December 12, 2019
    Inventors: Katherine E VARLEY, Richard M MYERS, Brian S ROBERTS, Jason GERTZ, Donald J Buchsbaum, Andres Forero-Torres, Albert F LoBuglio
  • Capture Methodologies for Circulating Cell Free DNA
    Publication number: 20180251757
    Abstract: A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target nucleic acid sequences are unknown.
    Type: Application
    Filed: May 2, 2018
    Publication date: September 6, 2018
    Inventors: Katherine E. Varley, D. Troy Moore, Randall Bachmeyer, David Kloske
  • METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION
    Publication number: 20180148757
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Application
    Filed: January 19, 2018
    Publication date: May 31, 2018
    Inventors: Robi M. Mitra, Katherine E. Varley
  • Capture methodologies for circulating cell free DNA
    Patent number: 9982255
    Abstract: A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target nucleic acid sequences are unknown.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: May 29, 2018
    Assignee: Kailos Genetics, Inc.
    Inventors: Katherine E. Varley, D. Troy Moore, Randall Bachmeyer, David Kloske
  • Method for multiplexed nucleic acid patch polymerase chain reaction
    Patent number: 9909170
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: March 6, 2018
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Robi M. Mitra, Katherine E. Varley
  • Novel Read-Through Fusion Polynucleotides and Polypeptides and Uses Thereof
    Publication number: 20170267733
    Abstract: The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts.
    Type: Application
    Filed: November 17, 2016
    Publication date: September 21, 2017
    Inventors: Katherine E. Varley, Richard M. Myers, Brian S. Roberts, Jason Gertz, Donald J. Buchsbaum, Andres Forero-Torres, Albert F. LoBuglio
  • METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION
    Publication number: 20150197788
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Application
    Filed: January 16, 2015
    Publication date: July 16, 2015
    Inventors: Robi M. Mitra, Katherine E. Varley
  • Method for multiplexed nucleic acid patch polymerase chain reaction
    Patent number: 8936912
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Grant
    Filed: July 24, 2012
    Date of Patent: January 20, 2015
    Assignee: Washington University
    Inventors: Robi M. Mitra, Katherine E. Varley
  • Capture Methodologies for Circulating Cell Free DNA
    Publication number: 20140256558
    Abstract: A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target nucleic acid sequences are unknown.
    Type: Application
    Filed: March 11, 2013
    Publication date: September 11, 2014
    Applicant: Kailos Genetics, Inc.
    Inventors: Katherine E. Varley, D. Troy Moore, Randall Bachmeyer, David Kloske
  • Novel Read-Through Fusion Polynucleotides and Polypeptides and Uses Thereof
    Publication number: 20140162296
    Abstract: The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts.
    Type: Application
    Filed: March 14, 2013
    Publication date: June 12, 2014
    Inventors: Katherine E. Varley, Richard M. Myers, Brian S. Roberts, Jason Gertz, Donald J. Buchsbaum, Andres Forero-Torres, Albert F. LoBuglio
  • Method for multiplexed nucleic acid patch polymerase chain reaction
    Patent number: 8586310
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: November 19, 2013
    Assignee: Washington University
    Inventors: Robi M. Mitra, Katherine E. Varley
  • METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION
    Publication number: 20120289414
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Application
    Filed: July 24, 2012
    Publication date: November 15, 2012
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Robi M. Mitra, Katherine E. Varley
  • METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION
    Publication number: 20100129874
    Abstract: The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
    Type: Application
    Filed: September 8, 2009
    Publication date: May 27, 2010
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Robi M. Mitra, Katherine E. Varley