Patents by Inventor Katherine J. Franz

Katherine J. Franz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prochelators as targeted prodrugs for prostate cancer and methods of making and using same
    Patent number: 11007273
    Abstract: The present disclosure provides prochelators as targeted prodrugs for cancer, such as prostate cancer, and methods of making and using the same.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: May 18, 2021
    Assignee: Duke University
    Inventors: Katherine J. Franz, Subha Bakthavatsalam, Tian Zhang, Daniel George, Mark Sleeper
  • PROCHELATORS AS TARGETED PRODRUGS FOR PROSTATE CANCER AND METHODS OF MAKING AND USING SAME
    Publication number: 20200171160
    Abstract: The present disclosure provides prochelators as targeted prodrugs for cancer, such as prostate cancer, and methods of making and using the same.
    Type: Application
    Filed: July 3, 2018
    Publication date: June 4, 2020
    Inventors: Katherine J. Franz, Subha Bakthavatsalam, Tian Zhang, Daniel George, Mark Sleeper
  • Antimicrobial prochelators to target drug-resistant bacteria and methods of making and using the same
    Patent number: 10533018
    Abstract: The present disclosure provides antibacterial prodrugs and methods of making and using the same.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: January 14, 2020
    Assignee: Duke University
    Inventors: Katherine J. Franz, David M. Besse, Patrick C. Seed
  • ANTIMICROBIAL PROCHELATORS TO TARGET DRUG-RESISTANT BACTERIA AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20180194778
    Abstract: The present disclosure provides antibacterial prodrugs and methods of making and using the same.
    Type: Application
    Filed: June 28, 2016
    Publication date: July 12, 2018
    Inventors: Katherine J. Franz, David M. Besse, Patrick C. Seed
  • PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE
    Publication number: 20170224712
    Abstract: The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.
    Type: Application
    Filed: December 20, 2016
    Publication date: August 10, 2017
    Inventors: Katherine J. Franz, Dennis J. Thiele, Marian Helsel, Richard Festa
  • Prochelators as broad-spectrum antimicrobial agents and methods of use
    Patent number: 9526740
    Abstract: The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: December 27, 2016
    Assignee: Duke University
    Inventors: Katherine J. Franz, Dennis J. Thiele, Marian Helsel, Richard Festa
  • PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE
    Publication number: 20160220592
    Abstract: The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.
    Type: Application
    Filed: April 8, 2016
    Publication date: August 4, 2016
    Inventors: Katherine J. Franz, Dennis J. Thiele, Marian Helsel, Richard Festa
  • Photolabile caged transition metal complexes and methods of using the same
    Patent number: 9365593
    Abstract: The present invention provides compounds of Formula I: along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: June 14, 2016
    Assignee: Duke University
    Inventors: Katherine J. Franz, Katie L. Ciesienski
  • Prochelators as broad-spectrum antimicrobial agents and methods of use
    Patent number: 9333213
    Abstract: The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 10, 2016
    Assignee: Duke University
    Inventors: Katherine J. Franz, Dennis J. Thiele, Marian Helsel, Richard Festa
  • Prochelators useful for inhibiting metal-associated toxicity
    Patent number: 9175016
    Abstract: Prochelator compounds of Formula I or Formula II: are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: November 3, 2015
    Assignee: Duke University
    Inventors: Katherine J. Franz, Marina G. D. Leed
  • Compositions and methods for imaging beta-secretase activity in living cells and organisms
    Patent number: 8859223
    Abstract: Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By fluorescing when hydrolyzed by BACE, the probes can allow for real-time spatial and temporal assessment of enzymatic activity without the need for mutated cell lines or antibodies. The molecular probes may also be used to screen libraries of potential BACE inhibitors or evaluate how external stimuli affect BACE activity.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 14, 2014
    Assignee: Duke University
    Inventors: Katherine J. Franz, Drew Folk
  • PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE
    Publication number: 20140274955
    Abstract: The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The present disclosure further provides pharmaceutical compositions and a kit comprising the prochelator therein.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Duke University
    Inventors: Katherine J. Franz, Dennis J. Thiele, Marian Helsel, Richard Festa
  • PROCHELATORS USEFUL FOR INHIBITING METAL-ASSOCIATED TOXICITY
    Publication number: 20140148414
    Abstract: Prochelator compounds of Formula I or Formula II: are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
    Type: Application
    Filed: January 30, 2014
    Publication date: May 29, 2014
    Applicant: Duke University
    Inventors: Katherine J. Franz, Marina G. D. Leed
  • Prochelators useful for inhibiting metal-associated toxicity
    Patent number: 8680077
    Abstract: Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: March 25, 2014
    Assignee: Duke University
    Inventors: Katherine J. Franz, Marina G. D. Leed
  • Prochelators for inhibiting metal-promoted oxidative stress
    Patent number: 8551976
    Abstract: The present invention provides compounds of Formula I along with compositions containing the same and methods of use thereof in treating oxidative stress.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: October 8, 2013
    Assignee: Duke University
    Inventors: Katherine J. Franz, Filip Kielar
  • Photolabile caged transition metal complexes and methods of using the same
    Patent number: 8440827
    Abstract: The present invention provides compounds of Formula I: (I) along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: May 14, 2013
    Assignee: Duke University
    Inventors: Katherine J. Franz, Katie L. Ciesienski
  • PROCHELATORS USEFUL FOR INHIBITING METAL-ASSOCIATED TOXICITY
    Publication number: 20130096085
    Abstract: Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.
    Type: Application
    Filed: July 22, 2010
    Publication date: April 18, 2013
    Inventors: Katherine J. Franz, Marina G. D, Leed
  • PROCHELATORS FOR INHIBITING METAL-PROMOTED OXIDATIVE STRESS
    Publication number: 20130035311
    Abstract: The present invention provides compounds of Formula I along with compositions containing the same and methods of use thereof in treating oxidative stress.
    Type: Application
    Filed: August 1, 2012
    Publication date: February 7, 2013
    Inventors: Katherine J. Franz, Filip Kielar
  • ROS-sensitive iron chelators and methods of using the same
    Patent number: 8236783
    Abstract: The present invention provides compounds of Formula (I): along with compositions containing the same and methods of use thereof in treating oxidative stress.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: August 7, 2012
    Assignee: Duke University
    Inventors: Katherine J. Franz, Louise K. Charkoudian
  • PHOTOLABILE CAGED TRANSITION METAL COMPLEXES AND METHODS OF USING THE SAME
    Publication number: 20110184333
    Abstract: The present invention provides compounds of Formula I: (I) along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
    Type: Application
    Filed: July 23, 2009
    Publication date: July 28, 2011
    Inventors: Katherine J. Franz, Katie L. Ciesienski