Abstract: The present disclosure relates to predicting a patient's response to cancer therapy based on the presence or absence of loss of function NOD-2 variants, as well as methods of treating cancer comprising inhibiting NOD-2 function.

Abstract: The present disclosure relates to an improved methodology for phenotyping and molecular characterisation of single cells using high-throughput and multiplexed targeted long-read single cell sequencing. In one particular example, the present disclosure relates to a methodology which combines targeted long-read sequencing with short-read based transcriptome profiling of barcoded single cell libraries generated by droplet-based partitioning for high throughput deep single cell profiling.

Abstract: A method of treating fly ash to modify the set time and the induction profile for a slurry comprising cement and the fly ash. The method comprising mixing fly ash with an aqueous solution comprising the calcium carbonate, thereby modifying the set time and the induction profile of the slurry comprising cement and the fly ash. A method of treating fly ash to modify the induction profile of a slurry comprising cement and the fly ash. The method comprising contacting fly ash with a wet gas stream comprising water vapor and carbon dioxide in an amount sufficient to react with the fly ash so as to modify the induction profile of the slurry comprising cement and the fly ash. Cement compositions comprising water, hydraulic cement, and carbonated fly, and associated methods of use.

Abstract: A polysiloxane copolymer composition comprises: a polysiloxane unit comprising 4 to 50 siloxane units, and a polyester-polycarbonate unit consisting of 50 to 100 mole percent of arylate ester units, less than 50 mole percent aromatic carbonate units, less than 30 mole percent resorcinol carbonate units, and less than 35 mole percent bisphenol carbonate units, wherein the siloxane units are present in the polysiloxane unit in an amount of 0.2 to 10 wt % of the total weight of the polysiloxane copolymer composition, and wherein the polysiloxane copolymer composition has a 2 minute integrated heat release rate of less than or equal to 65 kilowatt-minutes per square meter (kW-min/m2) and a peak heat release rate of less than 65 kilowatts per square meter (kW/m2) as measured using the method of FAR F25.4, in accordance with Federal Aviation Regulation FAR 25.853 (d). A window article for an aircraft, comprising the polysiloxane copolymer composition, is also disclosed.