Patents by Inventor Katherine L. Radtke

Katherine L. Radtke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLEX-NUCLEOSIDE ANALOGUES, NOVEL THERAPEUTICS AGAINST FILOVIRUSES AND FLAVIVIRUSES
    Publication number: 20220133756
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
    Type: Application
    Filed: January 6, 2022
    Publication date: May 5, 2022
    Inventor: KATHERINE L. RADTKE
  • Flex-nucleoside analogues, novel therapeutics against filoviruses and flaviviruses
    Patent number: 11253529
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: February 22, 2022
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Katherine L. Radtke
  • FLEX-NUCLEOSIDE ANALOGUES, NOVEL THERAPEUTICS AGAINST FILOVIRUSES AND FLAVIVIRUSES
    Publication number: 20200171060
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting flaviviruses, filoviruses and/or coronaviruses.
    Type: Application
    Filed: January 26, 2018
    Publication date: June 4, 2020
    Inventor: KATHERINE L. RADTKE
  • Thieno- and pyrrolopyrimidine analogues and prodrugs thereof as anticancer agents and methods of use thereof
    Patent number: 10646490
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds and prodrugs thereof that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: May 12, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventor: Katherine L. Radtke
  • Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
    Patent number: 10561658
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: February 18, 2020
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Katherine L. Radtke, Kartik Temburnikar
  • DESIGN, SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXMIER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY
    Publication number: 20190201352
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 4, 2019
    Inventors: KATHERINE L. RADTKE, HANNAH PETERS, JOHAN NEYTS, DIRK JOCHMANS, ERIC J. SNIJDER
  • THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AND PRODRUGS THEREOF AS ANTICANCER AGENTS AND METHODS OF USE THEREOF
    Publication number: 20190160071
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds and prodrugs thereof that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Application
    Filed: February 1, 2019
    Publication date: May 30, 2019
    Inventor: KATHERINE L. RADTKE
  • Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
    Patent number: 10226434
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: March 12, 2019
    Assignees: University of Maryland, Baltimore County, Katholieke Universiteit Leuven/Lieden University Medical Center, RC Leiden
    Inventors: Katherine L. Radtke, Hannah Peters, Johan Neyts, Dirk Jochmans, Eric J. Snijder
  • DESIGN, SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXMIER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY
    Publication number: 20180303768
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
    Type: Application
    Filed: July 2, 2018
    Publication date: October 25, 2018
    Inventors: KATHERINE L. RADTKE, HANNAH PETERS, JOHAN NEYTS, DIRK JOCHMANS, ERIC J. SNIJDER
  • Design, synthesis and methods of use of acyclic fleximer nucleoside analogues having anti-coronavirus activity
    Patent number: 10058516
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: August 28, 2018
    Assignees: University of Maryland Baltimore County, Katholieke Universiteit Leuven, Leiden University Medical Center
    Inventors: Katherine L. Radtke, Hannah L. Peters, Johan Neyts, Dirk Jochmans, Eric J. Snijder
  • THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF
    Publication number: 20180161330
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Application
    Filed: February 12, 2018
    Publication date: June 14, 2018
    Inventors: KATHERINE L. RADTKE, KARTIK TEMBURNIKAR
  • Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
    Patent number: 9895374
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: February 20, 2018
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Katherine L. Radtke, Kartik Temburnikar
  • DESIGN, SYNTHESIS AND METHODS OF USE OF ACYCLIC FLEXMIER NUCLEOSIDE ANALOGUES HAVING ANTI-CORONAVIRUS ACTIVITY
    Publication number: 20180015052
    Abstract: The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential with the result of inhibiting several coronaviruses.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 18, 2018
    Inventors: KATHERINE L. RADTKE, HANNAH L. PETERS, JOHAN NEYTS, DIRK JOCHMANS, ERIC J. SNIJDER
  • THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF
    Publication number: 20170014415
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Application
    Filed: August 29, 2016
    Publication date: January 19, 2017
    Inventors: KATHERINE L. RADTKE, KARTIK TEMBURNIKAR
  • THIENO- AND PYRROLOPYRIMIDINE ANALOGUES AS ANTICANCER AGENTS AND METHODS OF USE THEREOF
    Publication number: 20160257696
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Application
    Filed: March 2, 2015
    Publication date: September 8, 2016
    Inventors: KATHERINE L. RADTKE, Kartik Tembhurnikar
  • Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
    Patent number: 9434742
    Abstract: The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.
    Type: Grant
    Filed: March 2, 2015
    Date of Patent: September 6, 2016
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY
    Inventors: Katherine L. Radtke, Kartik Temburnikar