Patents by Inventor Katherine L. Widdowson

Katherine L. Widdowson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical compounds
    Patent number: 8354406
    Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: January 15, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Jianghe Deng, Jeffrey K. Kerns, Qi Jin, Guoliang Lin, Xichen Lin, Michael Lindenmuth, Christopher Neipp, Hong Nie, Sonia M Thomas, Katherine L. Widdowson
  • CHEMICAL COMPOUNDS
    Publication number: 20120035164
    Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: October 14, 2011
    Publication date: February 9, 2012
    Inventors: Jianghe DENG, Jeffrey K. KERNS, Qi JIN, Guoliang LIN, Xichen LIN, Michael LINDENMUTH, Christopher NEIPP, Hong NIE, Sonia M. THOMAS, Katherine L. WIDDOWSON
  • Chemical compounds
    Patent number: 8063071
    Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 22, 2011
    Assignee: GlaxoSmithKline, LLC
    Inventors: Jeffrey K. Kerns, Qi Jin, Michael Lindenmuth, Sonia M Thomas, Katherine L. Widdowson
  • METHOD OF TREATMENT
    Publication number: 20100256157
    Abstract: This invention relates to the use of a sulfonamide substituted diphenyl urea compound to treat cystic fibrosis, or the symptoms associated with cystic fibrosis.
    Type: Application
    Filed: March 19, 2010
    Publication date: October 7, 2010
    Inventors: Jakob Busch-Petersen, Thomas B. LEONARD, Michael R. Palovich, Henry M. Sarau, Aili L. Lazaar, Katherine L. Widdowson
  • IL-8 receptor antagonists
    Patent number: 7709485
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: May 4, 2010
    Assignee: GlaxoSmithkline LLC
    Inventors: Jakob Busch-Petersen, Michael R Palovich, Katherine L. Widdowson
  • Compounds
    Patent number: 7629350
    Abstract: Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: December 8, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Jeffrey C. Boehm, Katherine L. Widdowson, James F. Callahan, Zehong Wan
  • CHEMICAL COMPOUNDS
    Publication number: 20090143372
    Abstract: The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 4, 2009
    Inventors: Jianghe Deng, Jeffrey K. Kerns, Qi Jin, Guoliang Lin, Xichen Lin, Michael Lindenmuth, Christopher Neipp, Hong Nie, Sonia M. Thomas, Katherine L. Widdowson
  • IL-8 RECEPTOR ANTAGONISTS
    Publication number: 20090093492
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: October 9, 2007
    Publication date: April 9, 2009
    Inventors: Jakob Busch-Petersen, Michael R. Palovich, Katherine L. Widdowson
  • IL-8 receptor antagonists
    Patent number: 7008962
    Abstract: This invention relates to the novel use of dianilino squarates in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: March 7, 2006
    Assignee: Smithkline Beecham Corporation
    Inventors: Michael R. Palovich, Brent McCleland, Guangping Bi, Michelle Werner, Katherine L. Widdowson
  • Il-8 receptor antagonists
    Publication number: 20040132694
    Abstract: This invention relates to the novel use of amide squaramides in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: July 16, 2003
    Publication date: July 8, 2004
    Inventors: Michael R. Palovich, Katherine L. Widdowson
  • Methods of synthesizing phenol-contining compounds
    Publication number: 20040110954
    Abstract: Methods of synthesizing phenol-containing compounds are disclosed.
    Type: Application
    Filed: September 29, 2003
    Publication date: June 10, 2004
    Inventors: Michael R. Palovich, Katherine L. Widdowson
  • Il-8 receptor antagonists
    Publication number: 20040048897
    Abstract: This invention relates to the novel use of sulfonamide squaramides in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: July 16, 2003
    Publication date: March 11, 2004
    Inventors: Brent McCleland, Michael R. Palovich, Katherine L. Widdowson
  • IL-8 receptor antagonists
    Patent number: 6680317
    Abstract: This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: January 20, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael R. Palovich, Katherine L. Widdowson, Hong Nie
  • IL-8 receptor antagonists
    Publication number: 20030225125
    Abstract: This invention relates to novel phenyl ureas useful in the treatment of disease states mediated by the chemokine, Interleukin-3 (IL-3)
    Type: Application
    Filed: June 17, 2003
    Publication date: December 4, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Katherine L. Widdowson, Gregory M. Benson
  • IL-8 receptor antagonists
    Patent number: 6653347
    Abstract: This invention relates to the novel use of diphenyl sulfamido in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: November 25, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael R. Palovich, Joseph Weinstock, Katherine L. Widdowson
  • IL-8 receptor antagonists
    Patent number: 6653310
    Abstract: This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: November 25, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael R. Palovich, Katherine L. Widdowson, Hong Nie
  • Il-8 receptor anatagonists
    Publication number: 20030216375
    Abstract: This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: September 17, 2002
    Publication date: November 20, 2003
    Inventors: Michael R. Palovich, Katherine L. Widdowson, Hong Nie
  • Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists
    Publication number: 20030109527
    Abstract: The invention relates to novel hydroxy diphenylurea sulfonamides, compositions and intermediates thereof. The hydroxy diphenylurea sulfonamides are useful in the treatment of disease states mediated by the chemokine, Interleukin-8.
    Type: Application
    Filed: November 18, 2002
    Publication date: June 12, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Qi Jin, Brent W. McCleland, Michael R. Palovich, Katherine L. Widdowson
  • IL-8 receptor antagonists
    Patent number: 6566387
    Abstract: The invention relates to the use of guanidine compounds in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: May 20, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael R. Palovich, Katherine L. Widdowson
  • Il-8 receptor antagonists
    Publication number: 20030055260
    Abstract: This invention relates to the novel use of diphenyl sulfamido in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: August 30, 2002
    Publication date: March 20, 2003
    Inventors: Michael R. Palovich, Joseph Weinstock, Katherine L. Widdowson