Abstract: Systems, methods, and computer program products for generating an enhanced set of sequences for taxonomical classification are disclosed. In various embodiments, a plurality of reference sequences are received. Each of the plurality of reference sequences corresponds to a taxonomical classification. A label corresponding to at least one of the reference sequences is assigned to each of a plurality of supplemental sequences. Each of the plurality of supplemental sequences and each of the plurality of reference sequences are truncated to a region of interest to thereby generate a truncated set of sequences. Similarity is measured between pairs of truncated sequences in the truncated set of sequences to determine whether the similarity is above a predetermined threshold. An intermediate taxonomical label is assigned to the pair of truncated sequences in the truncated set of sequences when the similarity is above the predetermined threshold to thereby generate an enhanced set of sequences.