Patents by Inventor Katherine Louisa Widdowson

Katherine Louisa Widdowson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-MANNOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF URINARY TRACT INFECTIONS
    Publication number: 20230287028
    Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
    Type: Application
    Filed: April 28, 2023
    Publication date: September 14, 2023
    Inventors: Michael Joseph BISHOP, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
  • C-mannoside compounds useful for the treatment of urinary tract infections
    Patent number: 11697665
    Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: July 11, 2023
    Assignees: Fimbrion Therapeutics, Inc., GlaxoSmithKline Intellectual Property Development Limited
    Inventors: Michael Joseph Bishop, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
  • NOVEL COMPOUNDS
    Publication number: 20220298197
    Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment diseases such as urinary tract infection.
    Type: Application
    Filed: May 6, 2020
    Publication date: September 22, 2022
    Inventors: Michael Joseph BISHOP, James Walter JANETKA, Laurel Kathryn MCGRANE, Eugene Lee STEWART, Katherine Louisa WIDDOWSON
  • SUBSTITUTED BIPHENYL OR PHENYLHETEROARYL-MANNOSIDES AS ANTAGONISTS OF FIMH
    Publication number: 20220242900
    Abstract: Disclosed herein are new O-biphenyl- and O-phenylheteroarylmannoside compounds and compositions and their application as pharmaceuticals for use in the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment of diseases such as urinary tract infection.
    Type: Application
    Filed: June 17, 2020
    Publication date: August 4, 2022
    Inventors: Michael Joseph BISHOP, James Walter JANETKA, Laurel Kathryn MCGRANE, Katherine Louisa WIDDOWSON
  • Method for treating gonorrhea with (2R)-2-({4-[(3,4-dihydro-2H-pyrano[2,3-C]pyridin-6-ylmethyl)amino]-1-piperidinyl}methyl)-1,2-dihydro-3H,8H-2A,5,8A-triazaacenaphthylene-3,8-dione
    Patent number: 11229646
    Abstract: The present invention relates to methods for treating Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: January 25, 2022
    Inventor: Katherine Louisa Widdowson
  • C-MANNOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF URINARY TRACT INFECTIONS
    Publication number: 20210395287
    Abstract: Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
    Type: Application
    Filed: July 9, 2021
    Publication date: December 23, 2021
    Inventors: Michael Joseph BISHOP, Eugene L. STEWART, Katherine Louisa WIDDOWSON, James Walter JANETKA, Laurel Kathryn MCGRANE
  • C-mannoside compounds useful for the treatment of urinary tract infections
    Patent number: 11111262
    Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: September 7, 2021
    Assignees: GlaxoSmithKline Intellectual Property Development Limited, Fimbrion Therapeutics, Inc.
    Inventors: Michael Joseph Bishop, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
  • C-MANNOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF URINARY TRACT INFECTIONS
    Publication number: 20210017212
    Abstract: Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.
    Type: Application
    Filed: October 6, 2020
    Publication date: January 21, 2021
    Inventors: Michael Joseph BISHOP, Vincent J. Colandrea, Yuehu Li, Eugene L. Stewart, Iulia Strambeanu, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn Mcgrane
  • TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION
    Publication number: 20200330462
    Abstract: The present invention relates to methods for treating Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.
    Type: Application
    Filed: July 1, 2020
    Publication date: October 22, 2020
    Inventor: Katherine Louisa WIDDOWSON
  • Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones
    Patent number: 10702521
    Abstract: The present invention relates to methods for treating Neisseria Gonorrhoeae infection which comprises administering to a subject in need thereof novel 1,2-dihydro-2a,5,8a-triazaacenaphthylene-3,8-dione compounds: or pharmaceutically acceptable salts thereof and/or corresponding pharmaceutical compositions.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: July 7, 2020
    Assignee: GlaxoSmithKline Intellectual Property Development Limited
    Inventor: Katherine Louisa Widdowson
  • TRICYCLIC NITROGEN CONTAINING COMPOUNDS FOR TREATING NEISSERIA GONORRHOEA INFECTION
    Publication number: 20170304301
    Abstract: The present invention relates to methods for treating Neisseria gonorrhoeae infection which comprises administering to a subject in need thereof novel Tricyclic nitrogen containing compounds and corresponding pharmaceutical compositions as described herein.
    Type: Application
    Filed: August 20, 2015
    Publication date: October 26, 2017
    Inventor: Katherine Louisa WIDDOWSON
  • IL-8 receptor antagonists
    Patent number: 8044075
    Abstract: This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: October 25, 2011
    Assignee: GlaxoSmithKline
    Inventors: Gregory L. Adams, James A. Brackley, III, Jakob Busch-Petersen, Jianghe Deng, Wei Fu, Huijie Li, Jack J. Taggart, Feng Wang, Yonghui Wang, Katherine Louisa Widdowson, Hongyi Yu
  • IL-8 Receptor Antagonists
    Publication number: 20100298387
    Abstract: This invention relates to novel compounds, compositions and combinations thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: December 5, 2007
    Publication date: November 25, 2010
    Inventors: Gregory L. Adams, James A. Brackley, III, Jakob Busch-Petersen, Jianghe Deng, Wei Fu, Huijie Li, Jack J. Taggart, Feng Wang, Yonghui Wang, Katherine Louisa Widdowson, Hongyi Yi
  • IL-8 receptor antagonists
    Patent number: 6767922
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: July 27, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Il-8 receptor antagonists
    Patent number: 6664259
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: December 16, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Il-8 receptor antagonists
    Patent number: 6608077
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: September 5, 2002
    Date of Patent: August 19, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Il-8 receptor antagonists
    Publication number: 20030078250
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: September 6, 2002
    Publication date: April 24, 2003
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Il-8 receptor antagonists
    Publication number: 20030065170
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: September 5, 2002
    Publication date: April 3, 2003
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Il-8 receptor antagonists
    Publication number: 20030065188
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: September 6, 2002
    Publication date: April 3, 2003
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Il-8 receptor antagonists
    Publication number: 20030055286
    Abstract: 1 This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Application
    Filed: September 5, 2002
    Publication date: March 20, 2003
    Inventors: Katherine Louisa Widdowson, Qi Jin