Patents by Inventor Katherine M. Block

Katherine M. Block has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibiting interaction between the HIF-1ALPHA and p300/CBP with hydrogen bond surrogate-based helices
    Patent number: 9399666
    Abstract: The present invention relates to peptides having one or more stable, internally constrained ?-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: July 26, 2016
    Assignees: New York University, The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Paramjit S. Arora, Bogdan Olenyuk, Ross N. Chapman, Laura Henchey, Katherine M. Block
  • INHIBITING INTERACTION BETWEEN THE HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED
    Publication number: 20110245175
    Abstract: The present invention relates to peptides having one or more stable, internally constrained ?-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1?. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1? with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.
    Type: Application
    Filed: September 18, 2009
    Publication date: October 6, 2011
    Applicants: New York University, The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Paramjit S. Arora, Bogdan Olenyuk, Ross N. Chapman, Laura Henchey, Katherine M. Block