Abstract: This invention provides a holder for an imaging probe that attaches to a flexible arm, which accommodates a variety of sizes and shapes of probes, is lightweight and allows for easy attachment and detachment of probes. The probe holder includes a pair of confronting clamp plates that include clamping jaws for holding a probe or other item at their distal end. The distal ends of the plates can include elastomeric pads that conform to the shape of the probe being gripped. The proximal end of each plate includes a hemispherical well that engages a ball on a base member to define a highly flexible ball joint. This ball joint allows for easy fine adjustment of probe alignment, rotation and tilting, while frictionally maintaining the set position. A variety of alternate alignment and movement-limiting components can be employed.